Table 1 Extended list of contraindications to cornea prelevation at the Department of Ophthalmology, Saarland University Medical Center (UKS), Germany

1.

Unknown cause of death or significant disease of unknown etiology in the medical history

2.

Viral donor diseases: Infection with HIV, hepatitis B/C, HTLV I/II

3.

Bacterial donor diseases: Syphilis or other chronic persistent bacterial infections (brucellosis, typhus, rickettsioses, leprosy, relapsing fever, tularemia)

4.

Protozoonotic donor diseases: Babesiosis, trypanosomiasis (e.g., Chagas disease), Leishmaniasis

5.

Active systemic infections: bacterial, viral, fungal, parasitic or of unclear etiology

6.

Fungal sepsis or sepsis with multi-resistant germs (a bacterial sepsis with usual spectrum is not a contraindication)

7.

Central nervous disorders of unknown cause: (M. Alzheimer, M. Parkinson, unclear fast progressive Dementia, Multiple Sclerosis, Amyotrophic Lateral Sclerosis)

8.

Hematological neoplasias, leukemias, lymphomas

9.

Ophthalmic donor diseases with visible change in the cornea (corneal surgery, local infections, tumors of the eye)

10.

Risk of disease transmission by prions: recipients of dura mater, cornea, sclera, hetero- or xenografts; recipients of pituitary hormones

11.

Premortal uptake of substances that by transplanting can lead to a harmful effect (poisons, heavy metals)

12.

Donors who had premortal blood transfusion in the last 48 h with a limit of 22.5 ml per kg of body weight

13.

Time-limited exclusion:

2 years after healing: Salmonellosis, Q fever; Tuberculosis, Leptospirosis; 4 years after the cure of Malaria; 4 weeks after healing of Measles, Rubella, VZV

14.

Risk for ZIKA virus infection: (clinical signs of infection or stay within the last 28 days before death in a Zika virus endemic area (Uganda, Africa, Asia Micronesia, French Polynesia, Brazil, Columbia, Venezuela, Central America))

15.

Infections with MRSA / ESBL / VRSA