Table. 4 Studies related to the mutation spectrum of CC obtained using NGS in the past 5 years
| Â | Our cohort | Li et al., 2018 [37] | Gillespie et al., 2014 [17] | Ma et al., 2016 [19] | Zhai et al., 2017 [18] |
|---|---|---|---|---|---|
Target genes | 792 inherited eye diseases | 80 cataract-associated genes | 115 genes associated with CC | 32 cataract -associated genes | 54 cataract-associated genes |
Detection rate | Familial, 87.5% sporadic, 27.03% | familial, 75% sporadic, 47.8% | 70% | 70% | 62.96% |
Participants | 38 sporadic and 16 familial cases, 42 bilateral and 12 unilateral | 23 sporadic and 16 familial cases, all bilateral | 15 sporadic and 21 familial cases all bilateral 16 syndromic | 24 sporadic and 22 familial cases all bilateral nonsyndromic | 25 familial and 2 sporadic |