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Table 1 Corneal FLD (mm/mm2)

From: Topical citicoline and vitamin B12 versus placebo in the treatment of diabetes-related corneal nerve damage: a randomized double-blind controlled trial

 

Cit-B12

Placebo

P

Baseline

10.6 ± 2.9

12.7 ± 2.9

0.09

Month 4

13.4 ± 4.1*

15.8 ± 3.9*

0.07

Month 8

14.3 ± 4.1*

16.5 ± 2.9 *

0.08

Month 12

12.8 ± 4.1*

14.8 ± 3.0§

0.10

Month 18

14.2 ± 4.6*

14.4 ± 4.0^

0.43

  1. *, p < 0.0001; §, p = 0.01, ^, p = 0.03. All comparisons are vs baseline