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Table 4 Corneal esthesiometry: percentage improvement vs baseline

From: Topical citicoline and vitamin B12 versus placebo in the treatment of diabetes-related corneal nerve damage: a randomized double-blind controlled trial

 

Cit-B12

Placebo

P

Month 4

73% ± 79% (+ 317%; − 17%)

5% ± 11% (+ 27%; − 14%)

0.001

Month 8

143% ± 142% (+ 533%; − 31%)

44% ± 76% (+ 219%; − 18%)

0.02

Month 12

135% ± 115% (+ 338%; − 24%)

39% ± 82% (+ 244%; − 27%)

0.01

Month 18

153% ± 121% (+ 362%; − 27%)

44% ± 78% (+ 231%; − 37%)

0.007