Fig. 1

a and b High resolution Sagittal (a) and Axial T1 orbital Constructive Interference in Steady State (CISS) magnetic resonance imaging (b) prior to enucleation of left globe in a case with bilateral retinoblastoma showing a tumor mass with hemorrhage filling the posterior cavity, pushing the lens anteriorly, with optic nerve invasion beyond the lamina cribrosa. c and d Early Histopathological appearance of the optic nerve (ON) in the early initially submitted routine sections with tumor cells level of ON invasion (Dotted curve line) anterior to the lamina cribrosa (c) while deeper sections obtained were showing islands of tumor cells (black arrows) invading the ON posterior to the lamina cribrosa (d) (Original magnification × 200 Hematoxylin and eosin)