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Fig. 2 | BMC Ophthalmology

Fig. 2

From: Histopathological assessment of optic nerve invasion guided by radiological findings in enucleated globes with retinoblastoma

Fig. 2

a and b High resolution Sagittal and Axial orbital Constructive Interference in Steady State (CISS) and post contrast fat suppressed magnetic resonance imaging (a) showing invasion of the optic nerve (ON) up to 3 mm post lamina cribrosa (white arrow). Sagittal oblique magnetic resonance imaging view of the orbit (b) showing the posterior cavity is almost totally filled by tumor with interruption of the choroidal-retinal interface line (white arrow). c and d Deeper histopathological sections of the ON at the level of central artery (indicated by CR) with superficial invasion by retinoblastoma (RB) tumor cells (c). Histological sections (d) obtained after flipping of the tissue block showing tumor cells invading the ON (black arrows) and extending posterior to the lamina cribrosa (arrow head) (Original magnification × 200 Hematoxylin and eosin)

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