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Table 2 Sensitivity, specificity, accuracy, PPV and NPV of MRI compared to histopathology detection of ON invasion level (n = 38) excluding 6 cases that had treatment before enucleation

From: Histopathological assessment of optic nerve invasion guided by radiological findings in enucleated globes with retinoblastoma

Optic nerve invasion

TP (n)

FP (n)

TN (n)

FN (n)

Accuracy (%)

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

None

4

4

24

6

67.2

40.0

85.7

50.0

80.0

Prelaminar

0

6

20

12

52.6

0.0

76.9

0.0

62.5

Laminar

3

5

26

4

71.4

42.9

83.9

37.5

86.7

Postlaminar

8

8

21

1

63.3

88.9

72.4

50.0

95.5

  1. TP Total positive, FP False positive, TN Total negative, FN False negative, PPV Positive predictive value, NPV Negative predictive value