Table 2 Patient’s presentation
From: Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients
Investigations | Patients n/N (%) – Means +/− standard deviation | Patients diagnosed at the early stage n/N (%) - Means +/− standard deviation | Patients diagnosed at the chronic stage n/N (%) – Means +/− standard deviation | p |
|---|---|---|---|---|
First manifestation: | ||||
- bilateral loss of visual acuity | 27/41 (66) | 18/31 (58) | 9/10 (90) | 0.06 |
- unilateral loss of visual acuity | 10/41 (24) | 9/31 (29) | 1/10 (10) | 0.01 |
- ocular pain | 1/41 (2) | 0/31 (−) | 1/10 (10) | |
- neurological and auditory involvement | 2/41 (5) | 2/31 (6) | 0/10 (0) | |
Other | 1/41 (2) | 1/41 (2) | 0/10 (0) | |
Signs at ophthalmic clinical examination: | ||||
- Bilateral exudative detachment of the neurosensory retina | 29/41 (70) | 23/31 (74) | 6/10 (60) | 0.05 |
- Accumulation of liquid in the sub retinal space | 15/41 (37) | 11/31 (35) | 4/10 (40) | 0.22 |
- « Sunset glow fundus » | 2/41 (5) | 2/31 (6) | 0/10 (−) | |
Initial visual acuity (/10): | ||||
- Right eye | 4.6 +/− 3.6 | 4.3 +/− 3.7 | 4.3 +/− 3.5 | 0.84 |
- Left eye | 4.9 +/− 3.4 | 4.6 +/− 3.4 | 5.0 +/− 3.7 | 0.88 |
Angiography | ||||
- Delay in choroidal perfusion, causing hypofluorescence of circumscribed areas poorly perfused | 15/31 (48) | 11/25 (44) | 4/6 (66) | 0.47 |
- Hyperfluorescent leaking dots (pinpoints) | 17/31 (55) | 16/25 (64) | 1/6 (17) | 0.13 |
- Retinal pigment epithelium clumping and/or migration | 15/31 (48) | 13/25 (52) | 2/6 (33) | 0.55 |
Optical coherence findings: | ||||
- Diffuse choroidal thickening | 17/31 (55) | 15/25 (60) | 2/6 (33) | 0.36 |
Neurological and auditory investigations: | ||||
- Cerebrospinal Fluid pleiocytosis | 19/30 (63) | 12/21 (57) | 7/9 (78) | 0.21 |
- Audiological testing with a loss of hearing | 8/22 (36) | 5/18 (28) | 3/4 (75) | 0.13 |