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Table 1 Mendelian randomization estimates of the associations between serum lipid level and risk of POAG

From: Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization

Exposure

Method

n. SNP

β

95%CI

p

LDL-C

IVW

56

−0.00026

− 0.00062, 0.00011

0.165

LDL-C

MR Egger

56

−0.00051

−0.00107, 0.00005

0.078

LDL-C

Weighted median

56

−0.00040

−0.00088, 0.00008

0.099

LDL-C

Weighted mode

56

−0.00039

−0.00087, 0.00008

0.111

HDL-C

IVW

72

0.00023

−0.00015, 0.00061

0.238

HDL-C

MR Egger

72

0.00035

−0.00032, 0.00102

0.310

HDL-C

Weighted median

72

0.00041

−0.00015, 0.00097

0.151

HDL-C

Weighted mode

72

0.00053

−0.00005, 0.00111

0.077

TG

IVW

46

−0.00028

−0.00071, 0.00015

0.206

TG

MR Egger

46

0.00046

−0.00018, 0.00110

0.170

TG

Weighted median

46

−0.00017

−0.00076, 0.00042

0.569

TG

Weighted mode

46

3.63E-06

−0.00055, 0.00056

0.990

  1. POAG Primary open angle glaucoma, SNP Single nucleotide polymorphism, LDL Low density lipoprotein cholesterol, IVW Inverse variance weighted, HDL High density lipoprotein cholesterol, TG Triglycerides, β The effect of the effect allele, CI Confidence interval, p P-value from the GWAS