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Table 1 Mendelian randomization estimates of the associations between serum lipid level and risk of POAG

From: Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization

Exposure Method n. SNP β 95%CI p
LDL-C IVW 56 −0.00026 − 0.00062, 0.00011 0.165
LDL-C MR Egger 56 −0.00051 −0.00107, 0.00005 0.078
LDL-C Weighted median 56 −0.00040 −0.00088, 0.00008 0.099
LDL-C Weighted mode 56 −0.00039 −0.00087, 0.00008 0.111
HDL-C IVW 72 0.00023 −0.00015, 0.00061 0.238
HDL-C MR Egger 72 0.00035 −0.00032, 0.00102 0.310
HDL-C Weighted median 72 0.00041 −0.00015, 0.00097 0.151
HDL-C Weighted mode 72 0.00053 −0.00005, 0.00111 0.077
TG IVW 46 −0.00028 −0.00071, 0.00015 0.206
TG MR Egger 46 0.00046 −0.00018, 0.00110 0.170
TG Weighted median 46 −0.00017 −0.00076, 0.00042 0.569
TG Weighted mode 46 3.63E-06 −0.00055, 0.00056 0.990
  1. POAG Primary open angle glaucoma, SNP Single nucleotide polymorphism, LDL Low density lipoprotein cholesterol, IVW Inverse variance weighted, HDL High density lipoprotein cholesterol, TG Triglycerides, β The effect of the effect allele, CI Confidence interval, p P-value from the GWAS