Fig. 3From: Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelida 25X, H&E stained section reveals diffuse infiltration of neoplastic cells within the dermis with sparing of the epithelium. b 50X, H&E stained section shows infiltration of neoplastic cells into the subcutaneous adipose tissue without desmoplastic reaction. c 100X, H&E stained section reveals strands and aggregations of neoplastic cells interstitially arranged between collagen fibers. d 200X, H&E staining section shows histiocytoid cells with pale, granular eosinophilic cytoplasm with intracytoplasmic vacuolation. e 400X, H&E stained section shows histiocytoid morphology. The arrow points to a rare signet ring cell which is characterized by crescent-like nuclei and a main, centrally located cytoplasmic vacuole. f 400X, GATA3 stain shows positivityBack to article page