Skip to main content

Table 2 Subgroup analysis and meta-regression

From: The effect of diabetes on corneal endothelium: a meta-analysis

Subgroup

No.of studies

Fixed-effects model

Meta-regression

Heterogeneity

SMD (95%)

p-value

P value

I2 (%)

P-value

All

18

−0.352(− 0.538, − 0.166)

0.000*

 

85.7%

0.000*

Diabetes mellitus type

   

0.008*

  

Type1

4

−0.685(−1.390,0.019)

0.057

 

89.3%

0.000*

Type2

10

−0.341(− 0.517,-0.165)

0.000*

 

73.2%

0.000*

Type 1 and 2

4

−0.101(− 0.368,0.185)

0.491

 

79.9%

0.002*

area

   

0.823

  

Europe

7

−0.501(−0.910,-0.092)

0.016*

 

92.6%

0.000*

Asia

8

−0.214(− 0.366,-0.061)

0.006*

 

63.0%

0.008*

American

3

−0.382(− 0.711,-0.053)

0.023*

 

0.0%

0.724

Study design

   

0.717

  

Cross-sectional study

16

−0.391(−0.579,-0.203)

0.000*

 

84.9%

0.000*

Case-control study

2

−0.027(− 0.946,0.892)

0.95

 

91.5%

0.001*

Sample size

   

0.285

  

< 200

10

−0.202(−0.379,-0.025)

0.026*

 

51.6%

0.029*

> 200

8

−0.494(− 0.793,-0.195)

0.001*

 

92.2%

0.000*

Publication year

   

0.842

  

< 2010

8

−0.191(−0.401, 0.019)

0.075*

 

54.4%

0.032*

> 2010

10

−0.450(− 0.710,-0.191)

0.001*

 

90.6%

0.000*

Measurement tool

   

0.438

  

Contact

12

−0.423(−0.642,-0.203)

0.000*

 

88.7%

0.000*

noncontact

6

−0.158(− 0.465,0.149)

0.312

 

61.5%

0.024*

  1. * mean statistical difference