From: The effect of diabetes on corneal endothelium: a meta-analysis
Subgroup | No.of studies | Fixed-effects model | Meta-regression | Heterogeneity | ||
---|---|---|---|---|---|---|
SMD (95%) | p-value | P value | I2 (%) | P-value | ||
All | 18 | −0.352(− 0.538, − 0.166) | 0.000* | 85.7% | 0.000* | |
Diabetes mellitus type | 0.008* | |||||
Type1 | 4 | −0.685(−1.390,0.019) | 0.057 | 89.3% | 0.000* | |
Type2 | 10 | −0.341(− 0.517,-0.165) | 0.000* | 73.2% | 0.000* | |
Type 1 and 2 | 4 | −0.101(− 0.368,0.185) | 0.491 | 79.9% | 0.002* | |
area | 0.823 | |||||
Europe | 7 | −0.501(−0.910,-0.092) | 0.016* | 92.6% | 0.000* | |
Asia | 8 | −0.214(− 0.366,-0.061) | 0.006* | 63.0% | 0.008* | |
American | 3 | −0.382(− 0.711,-0.053) | 0.023* | 0.0% | 0.724 | |
Study design | 0.717 | |||||
Cross-sectional study | 16 | −0.391(−0.579,-0.203) | 0.000* | 84.9% | 0.000* | |
Case-control study | 2 | −0.027(− 0.946,0.892) | 0.95 | 91.5% | 0.001* | |
Sample size | 0.285 | |||||
< 200 | 10 | −0.202(−0.379,-0.025) | 0.026* | 51.6% | 0.029* | |
> 200 | 8 | −0.494(− 0.793,-0.195) | 0.001* | 92.2% | 0.000* | |
Publication year | 0.842 | |||||
< 2010 | 8 | −0.191(−0.401, 0.019) | 0.075* | 54.4% | 0.032* | |
> 2010 | 10 | −0.450(− 0.710,-0.191) | 0.001* | 90.6% | 0.000* | |
Measurement tool | 0.438 | |||||
Contact | 12 | −0.423(−0.642,-0.203) | 0.000* | 88.7% | 0.000* | |
noncontact | 6 | −0.158(− 0.465,0.149) | 0.312 | 61.5% | 0.024* |