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Table 3 Case reports and series of TSPK about treatment and prognosis

From: Thygeson’s superficial punctate keratitis (TSPK): a paediatric case report and review of the literature

Reported year Author(country) Total No. Treatment Prognosis
1966 Thygeson(America) [3] 27 7 Steroid Effective in suppressing symptoms and the epithelial opacities.
4 IDU(5-iodo-2’-de oxyuridine) Ineffective
1979 Abbott(America) [18] 1   Steroids and Artificial tears Remission and recurrence for 16 years
1979 Forstot(America) [25] 3 1 Steroids Relief of symptoms and good visual acuity for over 2 years
1 Dependent on corticosteroids.
1 Soft contact lenses Symptomatic relief
1980 Goldberg(America) [9] 4   Soft contact lenses Resolution of the lesions and relief of discomfort.
1981 Tabbara(America) [6] 45 32 Steroid 50% of the cases, exacerbation were controlled
2 Soft contact lenses Relieve the symptoms and improve the visual acuity
10 Scrapings No effect on the course of TSPK.
20 IDU and Antibiotics No effect on the course of TSPK.
1984 Nesburn(America) [10] 4   Trifluridine therapy Symptoms and later the signs of the disease disappeared
1999 Reinhard(Germany) [23] 17   Cyclosporin A 2% 71.5% of cases,complete suppression
2002 Reinhard(Germany) [22] 28   Cyclosporin A 2% 90.5%case improvement
2001 Fite(America) [12] 1   PRK Corneal lesions recurrence outside the laser ablation zone
2002 Goldstein(America) [8] 1   PRK No recurrences
2004 Nagra(America) [5] 40 35 Steroids Symptomatic relief
2 Artificial tears N/A
1 Soft contact lenses. N/A
2004 Netto(Brazil) [26] 1 OD PRK No recurrences
OS LASIK Recurrence after 10 month
2007 Duszak(America) [27] 1   Steroid Signs and symptoms disappeared
2008 Hasanreisoglu(Israel) [15] 1   Cyclosporin A 0.5% Symptom resolution and corneal clearing
2011 Fintelmann(America) [16] 4   Steroids Symptomatic relief and reduce the risk of corneal scarring.
2015 Chao Jiang(China) [28] 21   Steroids combined with antiviral drugs 17/21cured and 4/21 recurrence
2015 Marquezan(Brazil) [29] 14   Tacrolimus 0.03% eye ointment Improved VA, symptoms, and signs
  1. IDU 5-iodo-2’-de oxyuridine, N/A not available
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