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Table 3 Percent reduction of macular VD and GCC thickness in pre-perimetric and early perimetric glaucoma eyes (mean, 95% confidence interval)

From: Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

 

Pre-perimetric glaucoma

Early perimetric glaucoma

VD (%)

GCC Thickness (%)

P

VD (%)

GCC Thickness (%)

P

Global *, **

7.8 (5.0, 10.7)

10.6 (7.5, 13.7)

0.117

15.4 (10.6, 20.0)

22.0 (17.3, 26.6)

0.001

Global SH *, **

6.9 (4.0, 9.8)

9.3 (6.1, 12.5)

0.096

13.3 (8.2, 18.4)

18.4 (13.1, 23.6)

0.004

Global IH *, **

8.9 (5.7, 12.0)

11.7 (8.0, 15.4)

0.152

17.6 (12.7, 22.6)

25.4 (20.1, 30.7)

0.001

Regional

 Para *, **

5.1 (1.1, 9.0)

5.9 (2.3, 9.4)

0.338

11.2 (5.2, 17.3)

19.2 (12.9, 25.6)

0.001

 Peri *, **

7.9 (5.1, 10.7)

12.2 (9.1, 15.3)

0.019

16.1 (11.3, 20.8)

22.9 (18.4, 27.4)

0.001

 

P = 0.020

P < 0.001

 

P = 0.003

P = 0.040

 

 Para T *, **

3.5 (0.4, 6.5)

6.0 (1.9, 10.2)

0.128

12.2 (5.6, 18.9)

20.7 (14.9, 26.6)

0.001

 Para S **

5.2 (0.6, 9.7)

6.7 (2.9, 10.5)

0.234

9.2 (3.9, 14.6)

17.5 (11.2, 23.7)

0.001

 Para N **

8.2 (3.0, 13.4)

4.0 (1.2, 7.0)

0.873

11.8 (5.4, 18.2)

17.1 (9.7, 24.6)

0.018

 Para I *, **

3.4 (−0.01, 7.7)

6.6 (2.5, 10.6)

0.206

11.5 (4.6, 18.4)

21.7 (13.8, 29.6)

0.003

 Peri T *, **

7.1 (4.0, 10.3)

12.4 (8.8, 16.0)

0.014

14.2 (9.9, 18.5)

21.8 (17.8, 25.8)

0.001

 Peri S *, **

8.4 (5.4, 11.5)

12.8 (9.0, 16.7)

0.026

15.1 (9.6, 20.7)

21.5 (15.4, 27.6)

0.005

 Peri N *, **

5.0 (2.5, 7.5)

8.1 (5.2, 11.1)

0.103

13.6 (7.8, 19.3)

18.3 (13.0, 23.6)

0.013

 Peri I *, **

11.0 (7.5, 14.5)

16.5 (11.8, 21.5)

0.023

21.3 (16.3, 26.3)

31.0 (25.3, 36.7)

0.001

  1. A clustered Wilcoxon signed rank test using the Rosner-Glynn-Lee method was used to compare the percent reduction of macular VD or GCC thickness between different areas within each individual group
  2. P, P values between macular VD and GCC thickness or between the different regions in the individual group
  3. VD Vessel density, GCC Ganglion cell complex, SH Superior hemifield, IH Inferior hemifield, para Parafoveal, peri Perifoveal, T Temporal, S superior, N Nasal, I Inferior
  4. Multivariate analysis using a mixed effects model that was adjusted for age, sex, and SSI was used for the comparison between the PPG and early PG groups in terms of the percent reduction of VD (*, P < 0.05) and GCC thickness (**, P < 0.05)
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BMC Ophthalmology

ISSN: 1471-2415

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