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Table 1 Formaldehyde-releasing agents (FARs) included in the study, chemical names, acronyms, molecular weights and structure

From: Ex vivo anti-microbial efficacy of various formaldehyde releasers against antibiotic resistant and antibiotic sensitive microorganisms involved in infectious keratitis

Chemical name

Acronym

Moles of FA released per 1 mol of FAR

Molecular weight

Predicted octanol/water partition coefficient, LogP

Toxicity (LD50, dermal, rabbit)

Structure

Diazolidinyl urea (1-[3,4-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea)

DAU

4

278.22

−5.395 ± 0.866 [27]

> 2000 mg/kg [28]

1,3-Bis(Hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione

DMDM

2

188.18

−2.3 [29]

> 2000 mg/kg [30]

Sodium hydroxymethylglycinate

SMG

1

127.07

−1.197 [31]

> 2000 mg/kg [32]

2-(hydroxymethyl)-2-nitro-1,3-propanediol

NT

3

151.12

−0.115 ± 0.77 [27]

NA

2-nitro-1-propanol

NP

1

105.09

−0.066 ± 0.269 [27]

NA

Formaldehyde

FA

 

30.03

0.350 ± 0.145 [27]

NA