Fig. 2
The effect of Alda-1 intervention on the retinal structure of N-methyl-N-nitrosourea (MNU)-induced retinitis pigmentosa (RP) rats in vivo. a, b Typical retinal optical coherence tomography (OCT) images of rats on 1 day and 3 days (D1 and D3) after MNU administration and statistical analysis of the thickness from the retinal pigment epithelium (RPE) and outer plexiform layer (OPL) (the outer retina) and the whole retina in rats from all groups. MNU induced the convertion of outer nuclear layer (ONL) of rats in the model (M) group from hypo-reflectivity to hyper-reflectivity (shown by the “☆“in the figure) on D1 and D3 after MNU injection, with the thickness of the outer retina gradually decreasing. The ONL in OCT images of rats from the Alda-1 intervention (A) group was reverted into hypo-reflectivity on D3, which resembled that of the normal (N) group. The thickness of the outer retina of the A group was higher than that of the M group on D3. OPL: outer plexiform layer; RPE: retinal pigment epithelium. ON: optic nerve; Scale: 100 μm; ONL: outer nuclear layer. N: the normal group; M: the model group; A: the Alda-1 intervention group. *, **: P < 0.05, P < 0.01 vs. the N group; #, ##: P < 0.05, P < 0.01 vs. the M group