Comparison of adherence between fixed and unfixed topical combination glaucoma therapies using Japanese healthcare/pharmacy claims database: a retrospective non-interventional cohort study

Table 5 Risk factors for nonadherence (PDC < 80%) to medications

Variable	Univariate	Multivariate	Odds ratio (95% CI)
Variable	P Value	P Value	Odds ratio (95% CI)
Fixed vs. unfixed combination therapies	< 0.0001	< 0.0001	0.388 (0.259, 0.583)
Sex	0.4583
Age	0.6787
Body weight	0.9582
Height	0.4747
Body mass index	0.5763
Smoking habit	0.5399
Medication for other disease	0.9166
Antihypertensive drug	0.6910
Fasting blood glucose	0.4806
HbA1c	0.0219	0.0130	1.606 (1.105, 2.333)
Urine glucose	0.2091
Urine protein	0.3810
Systolic blood pressure	0.3303
Diastolic blood pressure	0.6046
Total cholesterol	0.3382
Triglyceride	0.7453
47 prefectures	> 0.9999
8 regions	0.7097
East vs. West Japan	0.1569
City size	0.4610
Hypertension	0.5190
Cancer	0.3087
Hyperlipidemia	0.8102
Diabetes mellitus	0.4790
Insomnia	0.1181
Liver disorder	0.9745
Asthma or COPD	0.6839
Gastrointestinal ulcer	0.7023
Atherosclerosis or PAOD	0.8851
Anemia	0.1098
Coronary artery disease	0.4576
Heart failure	0.1229

CI confidence interval, COPD chronic obstructive pulmonary disease, PAOD peripheral arterial occlusive disease, PDC proportion of days covered

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