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Table 5 Risk factors for nonadherence (PDC < 80%) to medications

From: Comparison of adherence between fixed and unfixed topical combination glaucoma therapies using Japanese healthcare/pharmacy claims database: a retrospective non-interventional cohort study

Variable Univariate Multivariate Odds ratio (95% CI)
P Value P Value
Fixed vs. unfixed combination therapies < 0.0001 < 0.0001 0.388 (0.259, 0.583)
Sex 0.4583   
Age 0.6787   
Body weight 0.9582   
Height 0.4747   
Body mass index 0.5763   
Smoking habit 0.5399   
Medication for other disease 0.9166   
Antihypertensive drug 0.6910   
Fasting blood glucose 0.4806   
HbA1c 0.0219 0.0130 1.606 (1.105, 2.333)
Urine glucose 0.2091   
Urine protein 0.3810   
Systolic blood pressure 0.3303   
Diastolic blood pressure 0.6046   
Total cholesterol 0.3382   
Triglyceride 0.7453   
47 prefectures > 0.9999   
8 regions 0.7097   
East vs. West Japan 0.1569   
City size 0.4610   
Hypertension 0.5190   
Cancer 0.3087   
Hyperlipidemia 0.8102   
Diabetes mellitus 0.4790   
Insomnia 0.1181   
Liver disorder 0.9745   
Asthma or COPD 0.6839   
Gastrointestinal ulcer 0.7023   
Atherosclerosis or PAOD 0.8851   
Anemia 0.1098   
Coronary artery disease 0.4576   
Heart failure 0.1229   
  1. CI confidence interval, COPD chronic obstructive pulmonary disease, PAOD peripheral arterial occlusive disease, PDC proportion of days covered
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