Variant | Study | Country | Ethnicity | n (cases/control) | Source of controls | Type of diabetes | Genotyping methods | DMC | Method of DR acertainment | NOS |
---|---|---|---|---|---|---|---|---|---|---|
UCP1 rs1800592 | Jin 2017 | China | Han Chinese | 1875 (530/1345) | Population-based study | T2DM | MassARRAY | DR | Direct ophthalmoscopy, fundus fluorescein angiography and OCT | 7 |
Jin 2020 | China | Han Chinese | 1235 (134/1101) | Hospital-based case-control | T2DM | Affymetrix Genome-Wide Human SNP Array 6.0 | DR | Direct ophthalmoscopy, fundus fluorescein angiography and OCT | 7 | |
Montesanto 2018 | Italy | European | 940 (435/505) | Population-based study | T2DM | MassARRAY | DR | Fundoscopy through dilated pupils and/or fluorescein angiography | 6 | |
Rudofsky 2007 | Germany | Caucasian | 517 (128/389) | Hospital-based case-control | T2DM | PCR-RFLPs | DR | Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography | 8 | |
Zhang 2014 | China | Han Chinese | 792 (488/344) | Hospital-based case-control | T2DM | PCR-LDR | NPDR, PDR | Fundoscopy and fundus fluorescein angiography | 8 | |
Zietz 2006 | Germany | Caucasian | 509 (194/315) | Population-based study | T2DM | PCR-RFLPs | NPDR, PDR | Fundus photograpy | 5 | |
Brondani 2012 | Brazil | European | 257 (154/103) | Hospital-based case-control | T1DM | PCR-RFLPs | DR | Fundoscopy through dilated pupils | 6 | |
Rudofsky 2006 | Germany | Caucasian | 227 (64/163) | Hospital-based case-control | T1DM | PCR-RFLPs | DR | Ophthalmoscopic examination | 7 | |
UCP2 rs659366 | Crispim 2010 | Brazil | European | 501 (242/259) 196 (85/111) | Hospital-based case-control | T1DM, T2DM | PCR-RFLPs | PDR | Fundoscopy through dilated pupils | 7 |
Jin 2017 | China | Han Chinese | 1875 (530/1344) | Population-based study | T2DM | MassARRAY | DR | Direct ophthalmoscopy, fundus fluorescein angiography and OCT | 7 | |
Jin 2020 | China | Han Chinese | 1235 (134/1101) | Hospital-based case-control | T2DM | Affymetrix Genome-Wide Human SNP Array 6.0 | DR | Direct ophthalmoscopy, fundus fluorescein angiography and OCT | 7 | |
Rudofsky 2007 | Germany | Caucasian | 645 (128/517) | Hospital-based case-control | T2DM | PCR-RFLPs | DR | Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography | 8 | |
Shen 2014 | China | Han Chinese | 472 (317/155) | Hospital-based case-control | T2DM | ABI 3100 genetic analyzer | NPDR, PDR | Fundoscopy through dilated pupils | 5 | |
Zhou 2018 | China | Han Chinese | 408 (209/199) | Hospital-based case-control | T2DM | ABI 3730 genetic analyzer | NPDR, PDR | Fundoscopy and fundus photograpy | 6 | |
Rudofsky 2006 | Germany | Caucasian | 227 (64/163) | Hospital-based case-control | T1DM | PCR-RFLPs | DR | Ophthalmoscopic examination | 7 |