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Table 1 Characteristics of the included studies

From: Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Variant Study Country Ethnicity n (cases/control) Source of controls Type of diabetes Genotyping methods DMC Method of DR acertainment NOS
UCP1 rs1800592 Jin 2017 China Han Chinese 1875 (530/1345) Population-based study T2DM MassARRAY DR Direct ophthalmoscopy, fundus fluorescein angiography and OCT 7
Jin 2020 China Han Chinese 1235 (134/1101) Hospital-based case-control T2DM Affymetrix Genome-Wide
Human SNP Array 6.0
DR Direct ophthalmoscopy, fundus fluorescein angiography and OCT 7
Montesanto 2018 Italy European 940 (435/505) Population-based study T2DM MassARRAY DR Fundoscopy through dilated pupils and/or fluorescein angiography 6
Rudofsky 2007 Germany Caucasian 517 (128/389) Hospital-based case-control T2DM PCR-RFLPs DR Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography 8
Zhang 2014 China Han Chinese 792 (488/344) Hospital-based case-control T2DM PCR-LDR NPDR, PDR Fundoscopy and fundus fluorescein angiography 8
Zietz 2006 Germany Caucasian 509 (194/315) Population-based study T2DM PCR-RFLPs NPDR, PDR Fundus photograpy 5
Brondani 2012 Brazil European 257 (154/103) Hospital-based case-control T1DM PCR-RFLPs DR Fundoscopy through dilated pupils 6
Rudofsky 2006 Germany Caucasian 227 (64/163) Hospital-based case-control T1DM PCR-RFLPs DR Ophthalmoscopic examination 7
UCP2 rs659366 Crispim 2010 Brazil European 501 (242/259)
196 (85/111)
Hospital-based case-control T1DM, T2DM PCR-RFLPs PDR Fundoscopy through dilated pupils 7
Jin 2017 China Han Chinese 1875 (530/1344) Population-based study T2DM MassARRAY DR Direct ophthalmoscopy, fundus fluorescein angiography and OCT 7
Jin 2020 China Han Chinese 1235 (134/1101) Hospital-based case-control T2DM Affymetrix Genome-Wide
Human SNP Array 6.0
DR Direct ophthalmoscopy, fundus fluorescein angiography and OCT 7
Rudofsky 2007 Germany Caucasian 645 (128/517) Hospital-based case-control T2DM PCR-RFLPs DR Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography 8
Shen 2014 China Han Chinese 472 (317/155) Hospital-based case-control T2DM ABI 3100 genetic analyzer NPDR, PDR Fundoscopy through dilated pupils 5
Zhou 2018 China Han Chinese 408 (209/199) Hospital-based case-control T2DM ABI 3730 genetic analyzer NPDR, PDR Fundoscopy and fundus photograpy 6
Rudofsky 2006 Germany Caucasian 227 (64/163) Hospital-based case-control T1DM PCR-RFLPs DR Ophthalmoscopic examination 7
  1. UCP uncoupling protein, T1DM type 1 diabetes mellitus, T2DM type 2 diabetes mellitus, DMC diabetes mellitus complications, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, NOS Newcastle-Ottawa quality assessment scale, n: number
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