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Table 1 Characteristics of the included studies

From: Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Variant

Study

Country

Ethnicity

n (cases/control)

Source of controls

Type of diabetes

Genotyping methods

DMC

Method of DR acertainment

NOS

UCP1 rs1800592

Jin 2017

China

Han Chinese

1875 (530/1345)

Population-based study

T2DM

MassARRAY

DR

Direct ophthalmoscopy, fundus fluorescein angiography and OCT

7

Jin 2020

China

Han Chinese

1235 (134/1101)

Hospital-based case-control

T2DM

Affymetrix Genome-Wide

Human SNP Array 6.0

DR

Direct ophthalmoscopy, fundus fluorescein angiography and OCT

7

Montesanto 2018

Italy

European

940 (435/505)

Population-based study

T2DM

MassARRAY

DR

Fundoscopy through dilated pupils and/or fluorescein angiography

6

Rudofsky 2007

Germany

Caucasian

517 (128/389)

Hospital-based case-control

T2DM

PCR-RFLPs

DR

Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography

8

Zhang 2014

China

Han Chinese

792 (488/344)

Hospital-based case-control

T2DM

PCR-LDR

NPDR, PDR

Fundoscopy and fundus fluorescein angiography

8

Zietz 2006

Germany

Caucasian

509 (194/315)

Population-based study

T2DM

PCR-RFLPs

NPDR, PDR

Fundus photograpy

5

Brondani 2012

Brazil

European

257 (154/103)

Hospital-based case-control

T1DM

PCR-RFLPs

DR

Fundoscopy through dilated pupils

6

Rudofsky 2006

Germany

Caucasian

227 (64/163)

Hospital-based case-control

T1DM

PCR-RFLPs

DR

Ophthalmoscopic examination

7

UCP2 rs659366

Crispim 2010

Brazil

European

501 (242/259)

196 (85/111)

Hospital-based case-control

T1DM, T2DM

PCR-RFLPs

PDR

Fundoscopy through dilated pupils

7

Jin 2017

China

Han Chinese

1875 (530/1344)

Population-based study

T2DM

MassARRAY

DR

Direct ophthalmoscopy, fundus fluorescein angiography and OCT

7

Jin 2020

China

Han Chinese

1235 (134/1101)

Hospital-based case-control

T2DM

Affymetrix Genome-Wide

Human SNP Array 6.0

DR

Direct ophthalmoscopy, fundus fluorescein angiography and OCT

7

Rudofsky 2007

Germany

Caucasian

645 (128/517)

Hospital-based case-control

T2DM

PCR-RFLPs

DR

Fundoscopy, indirect ophthalmoscopy and fundus fluorescein angiography

8

Shen 2014

China

Han Chinese

472 (317/155)

Hospital-based case-control

T2DM

ABI 3100 genetic analyzer

NPDR, PDR

Fundoscopy through dilated pupils

5

Zhou 2018

China

Han Chinese

408 (209/199)

Hospital-based case-control

T2DM

ABI 3730 genetic analyzer

NPDR, PDR

Fundoscopy and fundus photograpy

6

Rudofsky 2006

Germany

Caucasian

227 (64/163)

Hospital-based case-control

T1DM

PCR-RFLPs

DR

Ophthalmoscopic examination

7

  1. UCP uncoupling protein, T1DM type 1 diabetes mellitus, T2DM type 2 diabetes mellitus, DMC diabetes mellitus complications, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, NOS Newcastle-Ottawa quality assessment scale, n: number