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Table 4 Risk factor analysis for IRGBR failure

From: Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision

  Failure Definition 1 Failure Definition 2
Univariate Multivariate Univariate Multivariate
HR (95% CI) P Value HR (95% CI) P Value HR (95% CI) P Value HR (95% CI) P Value
Age (years)
65 Reference   Reference   Reference   Reference  
 <65 1.78 (0.67–4.75) 0.25 3.55 (1.06–11.9) 0.04 0.70 (0.32–1.54) 0.38 0.73 (0.30–1.80) 0.50
Sex
 Men Reference   Reference   Reference   Reference  
 Women 1.20 (0.48–3.03) 0.70 1.56 (0.48–5.15) 0.45 1.10 (0.50–2.40) 0.82 1.41 (0.53–3.78) 0.49
Glaucoma
 SOAG 1.10 (0.41–2.94) 0.85 1.13 (0.33–3.92) 0.85 1.45 (0.60–3.47) 0.41 3.43 (1.18–9.95) 0.02
 POAG Reference   Reference   Reference   Reference  
5-FU
 Yes Reference   Reference   Reference   Reference  
 No 5.07 (1.95–13.2) 0.0009 4.90 (1.37–17.5) 0.01 6.29 (2.65–15.0) < 0.0001 6.84 (2.28–20.5) 0.0006
No. previous surgeries
1 Reference   Reference   Reference   Reference  
2 0.95 (0.34–2.67) 0.93 2.29 (0.50–10.5) 0.29 0.93 (0.39–2.23) 0.87 1.47 (0.45–4.76) 0.53
No. IOP-lowering medications pre-needling
2 Reference   Reference   Reference   Reference  
3 1.20 (0.47–3.07) 0.70 1.21 (0.32–4.53) 0.78 1.10 (0.44–3.30) 0.85 1.38 (0.48–3.99) 0.55
IOP pre-needling (mmHg)
25 Reference   Reference   Reference   Reference  
 <25 1.52 (0.60–3.82) 0.38 1.73 (0.51–5.86) 0.38 1.52 (0.69–3.34) 0.30 1.97 (0.72–5.41) 0.19
IOP 1 week after needling (mmHg)
 <10 Reference   Reference   Reference   Reference  
10 4.63 (1.51–14.2) 0.007 5.54 (1.31–23.4) 0.02 3.19 (1.36–7.50) 0.008 3.99 (1.30–12.3) 0.02
Time between surgery and needling (years)
 <1 Reference   Reference   Reference   Reference  
1 0.61 (0.23–1.63) 0.33 0.93 (0.27–3.20) 0.91 0.66 (0.29–1.49) 0.31 0.87 (0.31–2.40) 0.79
  1. P values estimated using Cox proportional hazard model
  2. HR hazard ratio, CI confidence interval, 5-FU 5-fluorouracil, IOP intraocular pressure, IRGBR infrared-guided bleb revision, POAG primary open-angle glaucoma; SOAG, secondary open-angle glaucoma
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