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Table 1 Clinical Parameters of Dry Eye Disease

From: Changes in ocular surface and Meibomian gland after penetrating Keratoplasty

  Baseline 1 week 1 month 6 months 12 months
Value P (vs Baseline) Value P (vs Baseline) Value P (vs Baseline) Value P (vs Baseline)
Tear meniscus area (10−9 mm2) 40 ± 8 52 ± 9 0.179 42 ± 10 0.819 29 ± 7 0.290 34 ± 6 0.595
TBUT (sec) 2.9 ± 0.6 4.4 ± 0.5 0.027a 3.9 ± 0.5 0.259 4.4 ± 0.5 0.048a 4.3 ± 0.7 0.096
Corneal fluorescein staining score (0–15) 6.5 ± 1.1 6.7 ± 0.8 0.762 5.1 ± 0.7 0.283 3.5 ± 0.6 0.023a 3.3 ± 0.7 0.001a
Schirmer’s test I value (mm/5′) 15.4 ± 2.3 17.8 ± 2.2 0.356 13.4 ± 2.4 0.491 16.2 ± 2.3 0.764 16.5 ± 2.2 0.662
Lid margin abnormality (0–4) 1.9 ± 0.3 2.1 ± 0.2 0.410 1.9 ± 0.2 1.000 1.9 ± 0.2 1.000 2.0 ± 0.3 0.689
Meibum quality (0–24) 8.8 ± 1.4 11.3 ± 1.1 0.033a 10.7 ± 1.2 0.136 11.0 ± 1.3 0.161 12.7 ± 1.1 0.023a
Meibomian gland expressibility (0–3) 1.3 ± 0.2 1.8 ± 0.2 0.024a 1.6 ± 0.2 0.231 2.0 ± 0.2 0.019a 1.7 ± 0.2 0.083
Meiboscore (0–3) 1.2 ± 0.2 1.3 ± 0.2 1.2 ± 0.2 1.3 ± 0.2 1.3 ± 0.2
Lipid layer thickness (nm) 79.0 ± 4.1 95.6 ± 2.5 0.006a 86.9 ± 3.6 0.168 86.7 ± 3.8 0.158 81.1 ± 4.1 0.694
OSDI (0–100) 40.45 ± 4.42 39.73 ± 4.28 0.879 34.13 ± 4.42 0.070 23.14 ± 3.52 0.001a 28.78 ± 3.37 0.002a
  1. TBUT tear break up time, OSDI ocular surface disease index
  2. Results are expressed as mean ± SD
  3. aStatistical significance (P < 0.05)
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