Changes in ocular surface and Meibomian gland after penetrating Keratoplasty

BMC Ophthalmology

Table 1 Clinical Parameters of Dry Eye Disease

	Baseline	1 week		1 month		6 months		12 months
	Baseline	Value	P (vs Baseline)	Value	P (vs Baseline)	Value	P (vs Baseline)	Value	P (vs Baseline)
Tear meniscus area (10⁻⁹ mm2)	40 ± 8	52 ± 9	0.179	42 ± 10	0.819	29 ± 7	0.290	34 ± 6	0.595
TBUT (sec)	2.9 ± 0.6	4.4 ± 0.5	0.027^a	3.9 ± 0.5	0.259	4.4 ± 0.5	0.048^a	4.3 ± 0.7	0.096
Corneal fluorescein staining score (0–15)	6.5 ± 1.1	6.7 ± 0.8	0.762	5.1 ± 0.7	0.283	3.5 ± 0.6	0.023^a	3.3 ± 0.7	0.001^a
Schirmer’s test I value (mm/5′)	15.4 ± 2.3	17.8 ± 2.2	0.356	13.4 ± 2.4	0.491	16.2 ± 2.3	0.764	16.5 ± 2.2	0.662
Lid margin abnormality (0–4)	1.9 ± 0.3	2.1 ± 0.2	0.410	1.9 ± 0.2	1.000	1.9 ± 0.2	1.000	2.0 ± 0.3	0.689
Meibum quality (0–24)	8.8 ± 1.4	11.3 ± 1.1	0.033^a	10.7 ± 1.2	0.136	11.0 ± 1.3	0.161	12.7 ± 1.1	0.023^a
Meibomian gland expressibility (0–3)	1.3 ± 0.2	1.8 ± 0.2	0.024^a	1.6 ± 0.2	0.231	2.0 ± 0.2	0.019^a	1.7 ± 0.2	0.083
Meiboscore (0–3)	1.2 ± 0.2	1.3 ± 0.2	–	1.2 ± 0.2	–	1.3 ± 0.2	–	1.3 ± 0.2	–
Lipid layer thickness (nm)	79.0 ± 4.1	95.6 ± 2.5	0.006^a	86.9 ± 3.6	0.168	86.7 ± 3.8	0.158	81.1 ± 4.1	0.694
OSDI (0–100)	40.45 ± 4.42	39.73 ± 4.28	0.879	34.13 ± 4.42	0.070	23.14 ± 3.52	0.001^a	28.78 ± 3.37	0.002^a

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