A data-driven approach for the discovery of biomarkers associated with thyroid eye disease

BMC Ophthalmology

Table 3 Results of various enrichment analysis of identified gene biomarkers

Genes	Go Enrichment Term		Functional Categories (UP_KEYWORDS)	Disease enrichment class (GAD_DISEASE_CLASS)		Disease enrichment (GAD_DISEASE)			KEGG Pathways (Term)
Genes	inflammatory response	Immune Response	Cytokine	Vision	Immune	autoimmune disease	grave’s disease	Thyroid associated ophthalmopathies	autoimmune thyroid disease	Cytokine-cytokine receptor interaction
HIF1A	풙	풙	풙	✓	✓	풙	풙	풙	풙	풙
CXCL8	✓	✓	✓	✓	✓	풙	✓	풙	풙	✓
CXCL10	✓	✓	✓	풙	✓	풙	풙	풙	풙	✓
IL10	✓	✓	✓	✓	✓	✓		✓	✓	✓
IL17A	✓	✓	✓	풙	✓	풙	풙	풙	풙	✓
IL22	✓	✓	✓	풙	✓	풙	풙	풙	풙	✓
IL4	풙	✓	✓	✓	✓	✓	✓	✓	✓	✓
IL6	✓	✓	✓	✓	✓	✓	✓	풙	풙	✓
IL13	✓	✓	✓	✓	✓	풙	✓	풙	풙	✓
IGF1	풙	풙	풙	✓	✓	풙	풙	풙	풙	풙
TGFB1	✓	풙	풙	✓	✓	✓	풙	✓	풙	✓
IFNG	풙	✓	✓	✓	✓	✓	✓	풙	풙	✓
THBS1	✓	✓	풙	풙	풙	풙	풙	풙	풙	풙
TSHR	풙	풙	풙	✓	✓	풙	✓	풙	✓	풙
TNF-Alpha	풙	풙	풙	풙	풙	풙	풙	풙	풙	풙
HLA-C	풙	✓	풙	✓	✓	✓	풙	풙	✓	풙
CST3	풙	풙	풙	✓	풙	풙	풙	풙	풙	풙
SERPINA3	✓	풙	풙	✓	✓	풙	풙	풙	풙	풙
EGR1	풙	풙	풙	✓	✓	풙	풙	풙	풙	풙
FOS	✓	풙	풙	풙	풙	풙	풙	풙	풙	풙
MAF	풙	풙	풙	풙	풙	풙	풙	풙	풙	풙
NR4A1	풙	풙	풙	풙	풙	풙	풙	풙	풙	풙
Gene count	11	11	9	14	16	6	6	3	4	10

ISSN: 1471-2415