Table 4 Top 20 upregulated and downregulated differentially expressed genes (DEGs) in the JBZ group compared to the ZCR group
From: RNA sequencing and bioinformatics analysis of human lens epithelial cells in age-related cataract
Gene-id | log2FC | Pval | Up-down | Gene-id | log2FC | Pval | Up-down |
|---|---|---|---|---|---|---|---|
NR4A2 | 10.210411523 | 2.66E-60 | Up | DDX3Y | −9.523209533 | 1.56E-72 | Down |
NR4A3 | 8.218022790 | 1.39E-22 | Up | EIF1AY | −8.379329539 | 4.86E-20 | Down |
GRIA3 | 7.601604199 | 4.05E-47 | Up | PVALB | −8.200440025 | 1.76E-45 | Down |
ALDH1A2 | 6.166698445 | 8.92E-20 | Up | CLDN5 | −8.150297932 | 3.56E-32 | Down |
RGPD1 | 5.914488712 | 1.17E-05 | Up | RPS4Y1 | −7.891783293 | 1.91E-32 | Down |
BDNF | 5.490073820 | 0.008935371 | Up | LUM | −6.852847001 | 4.09E-10 | Down |
UNC5A | 5.263108777 | 0.025651215 | Up | C3 | −6.447255368 | 5.17E-41 | Down |
CAPN8 | 5.084626101 | 4.50E-07 | Up | SAA1 | −6.256915413 | 0.001039753 | Down |
SLC16A7 | 4.861755978 | 0.002948834 | Up | APOD | −5.958632573 | 2.67E-17 | Down |
ADAM33 | 4.843115831 | 7.86E-60 | Up | CHL1 | −5.886371002 | 4.57E-21 | Down |
MPZ | 4.686337999 | 0.00074464 | Up | ABCC3 | −5.584424022 | 4.19E-10 | Down |
TMEM74B | 4.645467019 | 0.000108655 | Up | PRF1 | −5.297684334 | 0.044650321 | Down |
RRH | 4.607044318 | 0.008796089 | Up | KRT78 | −5.152554180 | 0.026495957 | Down |
NKX3–2 | 4.331966849 | 0.029753521 | Up | OLAH | −5.139807536 | 0.017935704 | Down |
UROC1 | 4.315361957 | 0.027729575 | Up | FGR | −5.110041644 | 0.004889969 | Down |
PRSS55 | 4.281664428 | 0.01155766 | Up | ISM1 | −5.076786718 | 0.021961678 | Down |
ATP1A3 | 4.278127228 | 0.03309551 | Up | GPR160 | −5.054228043 | 0.000798287 | Down |
SLC7A5 | 4.231647204 | 2.05E-63 | Up | SERPINA3 | −4.933814790 | 1.01E-118 | Down |
RGS2 | 4.230358381 | 6.09E-08 | Up | SGPP2 | −4.916332934 | 0.001338125 | Down |
ATOH7 | 4.228904411 | 0.01977059 | Up | FABP9 | −4.767243914 | 0.04901258 | Down |