Table 2 Distribution of allele/genotype frequencies and genetic model analysis for TGFB − 509C > T (rs1800469) among all cases, POAG/PACG subtypes and controls

C

476 (54.09)

467 (54.69)

Ref

T

404 (45.91)

387 (45.31)

0.804

1.02 (0.84–1.23)

CC

125 (28.41)

120 (28.10)

Ref

CT

226 (51.36)

227 (53.16)

0.775

0.95 (0.70–1.30)

TT

89 (20.23)

80 (18.74)

0.742

1.06 (0.72–1.58)

CT + TT > CC

Dominant model

315 > 125

307 > 120

0.920

#0.950

0.98 (0.73–1.32)

1.01 (0.73–1.39)

TT > CT + CC

Recessive model

89 > 351

80 > 347

0.579

#0.196

1.09 (0.78–1.53)

1.26 (0.88–1.81)

CT > TT + CC

Co-dominant

226 > 214

227 > 200

0.596

#0.326

0.93 (0.71–1.21)

0.86 (0.64–1.15)

POAG n = 307 (%)

Controls n = 427(%)

C

334 (54.40)

467 (54.69)

Ref

T

280 (45.60)

387 (45.31)

0.913

1.01 (0.82–1.24)

CC

74 (24.10)

120 (28.10)

Ref

CT

186 (60.59)

227 (53.16)

0.110

1.32 (0.93–1.88)

TT

47 (15.31)

80 (18.74)

0.837

0.95 (0.60–1.51)

CT + TT > CC

Dominant model

233 > 74

307 > 120

0.225

#0.267

1.23 (0.87–1.72)

1.23 (0.85–1.79)

TT > CT + CC

Recessive model

47 > 260

80 > 347

0.226

#0.647

0.78 (0.52–1.16)

0.90 (0.59–1.38)

CT > TT + CC

Co-dominant

186 > 121

227 > 200

0.045*

#0.181

1.35 (1.00–1.82)

1.25 (0.90–1.73)

rs1800469

PACG n = 133(%)

Controls n = 427(%)

p-value

OR (95% CI)

C

142 (53.38)

467 (54.69)

Ref

T

124 (46.62)

387 (45.31)

0.710

1.05 (0.79–1.38)

CC

51 (38.35)

120 (28.10)

Ref

CT

40 (30.07)

227 (53.16)

0.0002*

0.41 (0.25–0.66)

TT

42 (31.58)

80 (18.74)

0.404

1.23 (0.75–2.03)

CT + TT > CC

Dominant model

82 > 51

307 > 120

0.025*

#0.087

0.62 (0.41–0.94)

0.66 (0.41–1.06)

TT > CT + CC

Recessive model

42 > 91

80 > 347

0.0019*

#0.001*

2.00 (1.29–3.10)

2.30 (1.39–3.79)

CT > TT + CC

Co-dominant

40 > 93

227 > 200

< 0.0001*

# < 0.0001*

0.37 (0.24–0.57)

0.35 (0.22–0.57)