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Table 2 Lid margin abnormality, meibomian gland function, and meibomian gland dysfunction stage before and after eyelid debris debridement and meibomian gland expression in patients with moderate and severe meibomian gland dysfunction

From: Effects of lid debris debridement combined with meibomian gland expression on the ocular surface MMP-9 levels and clinical outcomes in moderate and severe meibomian gland dysfunction

Parameters

Before treatment

4 weeks after the treatment

P value

Lid margin abnormality

 Lid margin irregularitya

  UL (0–2)

1.57 (0.07)

1.32 (0.08)

0.047

  LL (0–2)

1.57 (0.07)

1.36 (0.09)

0.117

 Telangiectasiaa

  UL (0–3)

1.96 (0.07)

1.37 (0.10)

< 0.001

  LL (0–3)

1.96 (0.07)

1.43 (0.10)

< 0.001

 Meibomian gland orifice plugginga

  UL (0–2)

1.79 (0.07)

1.05 (0.09)

< 0.001

  LL (0–2)

1.75 (0.09)

1.09 (0.09)

< 0.001

 Thicknessa

  UL (0–2)

1.60 (0.07)

1.02 (0.08)

< 0.001

  LL (0–2)

1.54 (0.07)

1.07 (0.09)

< 0.001

Mucocutaneous junction replacementb

26 (56.5%)

18 (40.9%)

0.115

Meibum characteristics

 Meibum colora

  UL (1–3)

1.92 (0.07)

1.66 (0.09)

0.026

  LL (1–3)

1.96 (0.09)

1.48 (0.08)

< 0.001

 Meibum consistencya

  UL (1–3)

1.69 (0.09)

1.25 (0.07)

< 0.001

  LL (1–3)

1.65 (0.07)

1.23 (0.06)

< 0.001

 Meibum gradeb

  UL (0–3)

38 (79.2%)

12 (25.0%)

< 0.001

MGD stageb

39 (84.8%)

10 (21.7%)

< 0.001

  1. MGD meibomian gland dysfunction, UL upper lid, LL lower lid
  2. aResults are presented as mean (standard error) and P values are from linear mixed model
  3. bGeneralized estimating equations model for noncontinuous scale values: mucocutaneous junction replacement, n (%, proportion for positive result), meibum grade, n (%, proportion ≥ grade 2), MGD stage, n (%, proportion ≥ stage 3)