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Table 2 Lid margin abnormality, meibomian gland function, and meibomian gland dysfunction stage before and after eyelid debris debridement and meibomian gland expression in patients with moderate and severe meibomian gland dysfunction

From: Effects of lid debris debridement combined with meibomian gland expression on the ocular surface MMP-9 levels and clinical outcomes in moderate and severe meibomian gland dysfunction

Parameters Before treatment 4 weeks after the treatment P value
Lid margin abnormality
 Lid margin irregularitya
  UL (0–2) 1.57 (0.07) 1.32 (0.08) 0.047
  LL (0–2) 1.57 (0.07) 1.36 (0.09) 0.117
 Telangiectasiaa
  UL (0–3) 1.96 (0.07) 1.37 (0.10) < 0.001
  LL (0–3) 1.96 (0.07) 1.43 (0.10) < 0.001
 Meibomian gland orifice plugginga
  UL (0–2) 1.79 (0.07) 1.05 (0.09) < 0.001
  LL (0–2) 1.75 (0.09) 1.09 (0.09) < 0.001
 Thicknessa
  UL (0–2) 1.60 (0.07) 1.02 (0.08) < 0.001
  LL (0–2) 1.54 (0.07) 1.07 (0.09) < 0.001
Mucocutaneous junction replacementb 26 (56.5%) 18 (40.9%) 0.115
Meibum characteristics
 Meibum colora
  UL (1–3) 1.92 (0.07) 1.66 (0.09) 0.026
  LL (1–3) 1.96 (0.09) 1.48 (0.08) < 0.001
 Meibum consistencya
  UL (1–3) 1.69 (0.09) 1.25 (0.07) < 0.001
  LL (1–3) 1.65 (0.07) 1.23 (0.06) < 0.001
 Meibum gradeb
  UL (0–3) 38 (79.2%) 12 (25.0%) < 0.001
MGD stageb 39 (84.8%) 10 (21.7%) < 0.001
  1. MGD meibomian gland dysfunction, UL upper lid, LL lower lid
  2. aResults are presented as mean (standard error) and P values are from linear mixed model
  3. bGeneralized estimating equations model for noncontinuous scale values: mucocutaneous junction replacement, n (%, proportion for positive result), meibum grade, n (%, proportion ≥ grade 2), MGD stage, n (%, proportion ≥ stage 3)