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Table 3 Multivariate logistic regression analysis about factors that could influence the appearance or progression of ERMs

From: Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Variables

Proportion

OR[95% CI]

p

Forced enter method

Smoking

never = 25 (33%) ago = 42 (55%) present = 9 (12%)

0.96 [0.27–3.41]

0.95

Lens status

phakia = 52 (68%) pseudophakia = 17 (22%) undergone surgery = 7 (9%)

1.20 [0.31–4.63]

0.80

Subretinal hemorrhage

no hemorrhage larger than 4-disc area = 69 (91%) present =7 (9%)

0.44 [0.04–4.85]

0.50

PVD status

no PVD = 4 (5%) complete PVD = 46 (61%) VMA = 18 (24%) progress = 8 (11%)

5.77 [1.72–19.4]

0.005

Peripheral degeneration

None = 49 (64%) lattice = 1 (1%) other degeneration (cobblestone, naevus, CHRPE, etc. = 26 (34%)

3.87 [1.15–13.0]

0.029

Type of AMD

PCV = 38 (50%) others = 38 (50%)

1.05 [0.33–3.38]

0.93

Contralateral eye at baseline

no ERM =35 (46%) present = 41 (54%)

1.17 [0.33–4.11]

0.81

Number of injections

mean 9.41 (±4.33) (times)

1.02 [0.90–1.16]

0.72

Forward-backwards stepwise method

PVD status

no PVD = 4 (5%) complete PVD = 46 (61%)

VMA = 18 (24%) progress = 8 (11%)

5.38 [1.73–16.7]

0.004

Peripheral degeneration

none = 49 (64%) lattice = 1 (1%) other degeneration (cobblestone, nevus, CHRPE, etc. = 26 (34%)

3.83 [1.23–12.0]

0.021

  1. ERM epiretinal membrane, OR odds ratio, CI confidence interval, PVD posterior vitreous detachment, VMA vitreomacular adhesion, CHRPE congenital hypertrophy of the retinal pigment epithelium, AMD age-related macular degeneration