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Table 4 Multivariate logistic regression analysis about factors that could have influence the appearance or progression of ERMs, examining aflibercept and ranibizumab independently

From: Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Variables

OR[95% CI]

p

Forced enter method

Smoking

0.95 [0.26–3.41]

0.94

Lens status

1.17 [0.30–4.53]

0.82

Subretinal hemorrhage

0.44 [0.04–4.82]

0.50

PVD status

5.88 [1.73–20.0]

0.005

Peripheral degeneration

3.74 [1.11–12.7]

0.034

Type of AMD

1.23 [0.34–4.48]

0.75

Contralateral eye at baseline

1.18 [0.33–4.29]

0.80

Number of aflibercept (mean7.19 ± 4.75)

1.01 [0.88–1.15]

0.94

Number of ranibizumab (mean 2.41 ± 3.12)

0.94 [0.76–1.16]

0.57

Forward-backwards stepwise method

PVD status

5.39 [1.73–16.7]

0.004

Peripheral degeneration

3.83 [1.23–12.0]

0.021

  1. Note: number of aflibercept and ranibizumab had negative correlation
  2. ERM epiretinal membrane, OR odds ratio, CI confidence interval, PVD posterior vitreous detachment, AMD age-related macular degeneration;
  3. (r = −0.49, [95%CI -0.64--0.29] p < 0.0001, Pearson correlation)