Table 1 Demographic, clinical and laboratory data and outcomes of previous reported cases with simultaneous NSOI and TED

2010

Bijlsma WR.

1

47

 F[2]

NR[3]

Autoimmune hypothyroidism

Progressive painless proptosis (OS)

NR

A posterior superior orbital mass (OS)

NSOI[4]

Oral prednisone

Complete resolution

11 months

NR

NR

Diffuse retro bulbar mass

NSOI (OD)

Oral prednisone

NR

4 years

Eyelid retraction + proptosis (OD)

NR

EOM[5]enlargement

(OU)

GO[6]

(Positive ATA[7])

Surgical correction of eyelid retraction

Complete resolution

2

35

F

NR

Primary hypothyroidism

Subacute eyelid swelling + proptosis + eyeball motility restriction + pain (OD)

NR

lacrimal gland enlargement (OD)

NSOI (dacryoadenitis)

Methyl prednisolone IV

NR

4 months

Diplopia

+

Upper eyelid retraction (OS)

NR

EOM enlargement (OS)

Unilateral GO

(Positive ATA)

Radiotherapy

NR

4 years

NR

NR

NR

NSOI (Dacryoadenitis)

Methyl prednisolone IV

NR

3

30

M[8]

Diabetes mellitus

+

Crohn disease

Hyperthyroidism

Painless proptosis + eyeball motility restriction + upper eyelid retraction

(OU)

NR

EOM enlargement (OU)

GO

(Positive ATA)

-

Complete resolution without therapy

9 years

Proptosis + eyeball motility restriction (OS)

NR

Lacrimal gland enlargement

(OS)

NSOI (Dacryoadenitis)

Oral prednisone

NR

2 months

Proptosis + eyeball motility restriction (OD)

NR

Lacrimal gland enlargement

(OD)

NSOI (Dacryoadenitis)

Oral prednisone

NR

4

22

M

NR

Euthyroidism

Proptosis + eyeball motility restriction + pain (OS)

NR

Medial superior orbital mass (OS)

NSOI

(Fibrosing)

Radiotherapy +

Oral prednisone

NR

5 years

Progressive proptosis

(OS)

NR

EOM enlargement

(OD)

GO

(Positive ATA) (Normal TFT)

Surgical decompression

Complete resolution

-

-

-

-

-

-

-

2011

Kubota T.

5

64

F

NR

GO associated with hyperthyroidism

(Positive ATA)

Upper eyelid mass

(OS)

NR

Anterior superior orbital infiltrative lesions (OU)

NSOI

(Ocular adnexal IgG4-related

Inflammation)

Oral prednisone

30 mg/day with slow tapering

Partial resolution

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2012

Tachibana S.

6

52

M

Hyperuricemia

Partial hepatectomy

Smoker

Hyperthyroid

- Under treatment with Methimazol

- Subclinical hypothyroidism at the time of complaint

Eye pain + Severe motility restriction

(OS)

+

Diplopia

VA[9]: 20/20 (OD)

20/40 (OS)

CAS[10]: 6/7 (OS)

Ptosis + Lid retraction

(OS)

Exophthalmometer:

17 mm (OD) + 17 mm (OS)

SR[11]enlargement with tendon involvement

Simultaneous TED 12 and NSOI

Methyl prednisolone IV

1 gr 3 times/ week

Dramatic improvement after 2 months:

VA: 20/25 (OD)

20/22 (OS)

CAS: 0/7 (OS)

Exophthalmometer:

17 mm (OD) + 17 mm (OS)

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2014

Detorakis E.

7

46

M

Testicular seminoma surgically removed 20 years ago

NR

Proptosis (OU)

+

Ocular hypertension (OD)

VA; 20/25 (OD)

20/20 (OS)

IOP:32 mmHg (OD)

17 mmHg (OS).

Exophthalmometer:

28 mm (OD) + 26 mm (OS)

Fusiform EOM enlargement Specially in IR[13](OD)

+

Infratemporal intraorbital tumor

in apposition with the posterior aspect of the globe (OD)

Simultaneous TED and Sclerosing NSOI

Oral prednisone

1 mg/kg (6 weeks)

Reduction in size and vascularity after 6 months

IOP: 17 (OD)

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2015

Shen T.

8

42

M

NR

Hyperthyroidism

(5 years)

Proptosis for 2 years + Moderate upper eyelid retraction +

Moderate motility restriction

(OD)

VA: 25/30 (OD)

25/20 (OS)

IOP: normal (OU)

Exophthalmometer : 24 mm (OD) + 17 mm (OS)

MR [15] + LR[16]enlargement with tendon sparing (OD)

+

Ambiguous soft tissue mass of

1.8 × 1.5 cm in retro bulbar cone region (OD).

Simultaneous TED and NSOI

Methyl prednisolone IV 500 mg (5 days)

+ oral prednisone 50 mg (5 days)

+ tapering during 2 months

Complete resolution

No recurrence after 6 months

-

-

-

-

-

-

-

-

-

-

-

-

-

-

9

49

M

NR

Hyperthyroidism

(8 years)

- Under treatment with PTU

Proptosis for 8 years (OU)

+

Eye redness for 2 months (OU)

+

Mild diplopia for 2 months

VA: Normal (OU)

Severe motility restriction (OU)

Exophthalmometer:

27 mm (OD) + 28 mm (OS)

SR and IR enlargement

with tendon sparing (OU)

+

Inferior orbital soft tissue mass of 2.1 × 1.4 cm (OD)

+

Inferior orbital soft tissue mass of 1.5 × 1.2 cm (OS)

Simultaneous TED and NSOI

Methyl prednisolone IV 500 mg (5 days)

+ oral prednisone 50 mg (5 days)

+ tapering during 1 months

Complete resolution

1 year

NR

NR

NR

IOID

Oral prednisone

NR

-

-

-

-

-

-

-

10

48

F

NR

Hyperthyroidism

(3 years)

Proptosis (OU)

VA: Normal (OU)

Orbital masses in lacrimal area (OU) + Inferior orbital mass (OS)

Mild motility restriction in medial & lateral gaze (OS) + lateral gaze (OD)

Exophthalmometer:

17 mm (OD) + 20 mm (OS)

LR & MR enlargement with tendon sparing (OS)

Inferior orbital soft tissue mass of 1.5 × 1.2 cm (OS)

MR enlargement (OD)

2 well-defined homogeneous soft tissue masses of 1.1 × 1.0 cm and 0.9 × 0.6 cm in lacrimal gland

areas (OU)

Simultaneous TED and NSOI

Dexamethasone IV 10 mg (5days)

+ oral prednisone 40 mg (5 days)

Complete resolution

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2017

Shieh WS.

11

68

F

Well controlled hypertension

Smoker

NR

Progressive proptosis (OD)

VA: 20/40 (OD)

20/25 (OS0

Inferior & lateral gaze restriction (OD)

Upper eyelid retraction + lagophthalmos (OD)

SR & IR & MR enlargement with tendon sparing (OD)

well circumscribed superior orbital mass (OD)

lacrimal gland enlargement (OD)

Maxillary sinus opacification & orbital floor bowing & bony erosion (OU)

Simultaneous TED and NSOI (dacryoadenitis)

+

Silent sinus syndrome

Endoscopic sinus drainage surgery

&

endoscopic medial orbital decompression (OD)

&

Oral prednisone

Partial resolution of proptosis

-

-

-

-

-

-

-

-

-

-

-

-

-

-