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Table 1 Clinical data of GO groups and controls

From: In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves’ orbitopathy

Clinical data

Active GO (34 eyes)

Inactive GO (46 eyes)

Controls (62 eyes)

P*

Age, years

50.65 ± 9.49

46.50 ± 10.80

45.65 ± 14.63

0.156a

Proptosis, mm

19.94 ± 3.83

17.63 ± 3.11

14.24 ± 1.06

0.000b

Palpebral fissure height, mm

11.37 ± 2.03

10.18 ± 1.78

8.76 ± 0.71

0.000c

Lagophthalmos, mm

0.99 ± 0.95

0.26 ± 0.65

0.00 ± 0.00

0.000d

CAS

3.56 ± 0.69

0.96 ± 0.72

 

0.000

Duration of GO, months

11.24 ± 12.18

16.82 ± 21.32

 

0.136

OSDI score

27.49 ± 15.11

23.14 ± 10.15

22.81 ± 18.93

0.345e

LLT, nm

73.09 ± 19.46

65.76 ± 13.68

66.98 ± 19.89

0.174f

PBR, %

51.74 ± 29.11

56.98 ± 25.03

37.10 ± 25.30

0.000g

NIF-BUT, s

6.09 ± 3.72

6.78 ± 3.86

8.20 ± 4.09

0.032h

NIAvg-BUT, s

8.26 ± 3.28

8.57 ± 3.61

9.58 ± 3.46

0.153i

TBUA, %

8.41 ± 9.65

8.16 ± 9.75

3.58 ± 5.17

0.005j

CFS

2.18 ± 2.15

0.72 ± 0.97

0.37 ± 0.55

0.000k

SIT, mm

7.00 ± 5.11

9.74 ± 4.00

10.77 ± 8.20

0.025l

MG dropout

1.62 ± 0.77

1.00 ± 0.29

0.82 ± 0.55

0.000m

Meibum quality

1.24 ± 0.60

1.02 ± 0.61

0.66 ± 0.65

0.000n

MG expressibility

1.09 ± 0.66

0.87 ± 0.74

0.71 ± 0.68

0.044o

  1. Data are presented as mean ± standard deviation (SD), n (%) or median (range), as appropriate
  2. GO Graves’ orbitopathy, CAS Clinical activity score, OSDI Ocular surface disease index, LLT Tear film lipid layer thickness, PBR Partial blinking rate, NIF-BUT Noninvasive first breakup time, NIAvg-BUT Noninvasive average breakup time, TBUA Tear film breakup area, CFS Corneal fluorescein staining, SIT Schirmer I test
  3. * Obtained by Kruskal-Wallis test
  4. a Active GO vs. Inactive GO: P = 0.078; Active GO vs. Control: P = 0.206; Inactive GO vs. Control: P = 0.960 (Mann- Whitney U test)
  5. b Active GO vs. Inactive GO: P = 0.006; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  6. c Active GO vs. Inactive GO: P = 0.003; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  7. d Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  8. e Active GO vs. Inactive GO: P = 0.205; Active GO vs. Control: P = 0.056; Inactive GO vs. Control: P = 0.116 (Mann- Whitney U test)
  9. f Active GO vs. Inactive GO: P = 0.069; Active GO vs. Control: P = 0.116; Inactive GO vs. Control: P = 0.891 (Mann- Whitney U test)
  10. g Active GO vs. Inactive GO: P = 0.319; Active GO vs. Control: P = 0.019; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  11. h Active GO vs. Inactive GO: P = 0.414; Active GO vs. Control: P = 0.013; Inactive GO vs. Control: P = 0.058 (Mann- Whitney U test)
  12. i Active GO vs. Inactive GO: P = 0.922; Active GO vs. Control: P = 0.135; Inactive GO vs. Control: P = 0.143 (Mann- Whitney U test)
  13. j Active GO vs. Inactive GO: P = 0.545; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.006 (Mann- Whitney U test)
  14. k Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.092 (Mann- Whitney U test)
  15. l Active GO vs. Inactive GO: P = 0.002; Active GO vs. Control: P = 0.037; Inactive GO vs. Control: P = 0.501 (Mann- Whitney U test)
  16. m Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.041 (Mann- Whitney U test)
  17. n Active GO vs. Inactive GO: P = 0.126; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.004 (Mann- Whitney U test)
  18. o Active GO vs. Inactive GO: P = 0.101; Active GO vs. Control: P = 0.011; Inactive GO vs. Control: P = 0.298 (Mann- Whitney U test)