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Table 1 Clinical data of GO groups and controls

From: In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves’ orbitopathy

Clinical data Active GO (34 eyes) Inactive GO (46 eyes) Controls (62 eyes) P*
Age, years 50.65 ± 9.49 46.50 ± 10.80 45.65 ± 14.63 0.156a
Proptosis, mm 19.94 ± 3.83 17.63 ± 3.11 14.24 ± 1.06 0.000b
Palpebral fissure height, mm 11.37 ± 2.03 10.18 ± 1.78 8.76 ± 0.71 0.000c
Lagophthalmos, mm 0.99 ± 0.95 0.26 ± 0.65 0.00 ± 0.00 0.000d
CAS 3.56 ± 0.69 0.96 ± 0.72   0.000
Duration of GO, months 11.24 ± 12.18 16.82 ± 21.32   0.136
OSDI score 27.49 ± 15.11 23.14 ± 10.15 22.81 ± 18.93 0.345e
LLT, nm 73.09 ± 19.46 65.76 ± 13.68 66.98 ± 19.89 0.174f
PBR, % 51.74 ± 29.11 56.98 ± 25.03 37.10 ± 25.30 0.000g
NIF-BUT, s 6.09 ± 3.72 6.78 ± 3.86 8.20 ± 4.09 0.032h
NIAvg-BUT, s 8.26 ± 3.28 8.57 ± 3.61 9.58 ± 3.46 0.153i
TBUA, % 8.41 ± 9.65 8.16 ± 9.75 3.58 ± 5.17 0.005j
CFS 2.18 ± 2.15 0.72 ± 0.97 0.37 ± 0.55 0.000k
SIT, mm 7.00 ± 5.11 9.74 ± 4.00 10.77 ± 8.20 0.025l
MG dropout 1.62 ± 0.77 1.00 ± 0.29 0.82 ± 0.55 0.000m
Meibum quality 1.24 ± 0.60 1.02 ± 0.61 0.66 ± 0.65 0.000n
MG expressibility 1.09 ± 0.66 0.87 ± 0.74 0.71 ± 0.68 0.044o
  1. Data are presented as mean ± standard deviation (SD), n (%) or median (range), as appropriate
  2. GO Graves’ orbitopathy, CAS Clinical activity score, OSDI Ocular surface disease index, LLT Tear film lipid layer thickness, PBR Partial blinking rate, NIF-BUT Noninvasive first breakup time, NIAvg-BUT Noninvasive average breakup time, TBUA Tear film breakup area, CFS Corneal fluorescein staining, SIT Schirmer I test
  3. * Obtained by Kruskal-Wallis test
  4. a Active GO vs. Inactive GO: P = 0.078; Active GO vs. Control: P = 0.206; Inactive GO vs. Control: P = 0.960 (Mann- Whitney U test)
  5. b Active GO vs. Inactive GO: P = 0.006; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  6. c Active GO vs. Inactive GO: P = 0.003; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  7. d Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  8. e Active GO vs. Inactive GO: P = 0.205; Active GO vs. Control: P = 0.056; Inactive GO vs. Control: P = 0.116 (Mann- Whitney U test)
  9. f Active GO vs. Inactive GO: P = 0.069; Active GO vs. Control: P = 0.116; Inactive GO vs. Control: P = 0.891 (Mann- Whitney U test)
  10. g Active GO vs. Inactive GO: P = 0.319; Active GO vs. Control: P = 0.019; Inactive GO vs. Control: P = 0.000 (Mann- Whitney U test)
  11. h Active GO vs. Inactive GO: P = 0.414; Active GO vs. Control: P = 0.013; Inactive GO vs. Control: P = 0.058 (Mann- Whitney U test)
  12. i Active GO vs. Inactive GO: P = 0.922; Active GO vs. Control: P = 0.135; Inactive GO vs. Control: P = 0.143 (Mann- Whitney U test)
  13. j Active GO vs. Inactive GO: P = 0.545; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.006 (Mann- Whitney U test)
  14. k Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.092 (Mann- Whitney U test)
  15. l Active GO vs. Inactive GO: P = 0.002; Active GO vs. Control: P = 0.037; Inactive GO vs. Control: P = 0.501 (Mann- Whitney U test)
  16. m Active GO vs. Inactive GO: P = 0.000; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.041 (Mann- Whitney U test)
  17. n Active GO vs. Inactive GO: P = 0.126; Active GO vs. Control: P = 0.000; Inactive GO vs. Control: P = 0.004 (Mann- Whitney U test)
  18. o Active GO vs. Inactive GO: P = 0.101; Active GO vs. Control: P = 0.011; Inactive GO vs. Control: P = 0.298 (Mann- Whitney U test)