Relationship between structural and functional changes in glaucomatous eyes: a multifocal electroretinogram study

Tanaka, Hiroki; Ishida, Kyoko; Ozawa, Kenji; Ishihara, Takuma; Sawada, Akira; Mochizuki, Kiyofumi; Yamamoto, Tetsuya

doi:10.1186/s12886-021-02061-8

BMC Ophthalmology

Table 2 Correlation between the N/T of mfERG, the macula thickness of OCT, and the mean thresholds and the total deviation of HFA 10–2 in each sector in glaucoma patients

From: Relationship between structural and functional changes in glaucomatous eyes: a multifocal electroretinogram study

OCT and HFA		vs N/T (IQR: 0.59–1.024)
Parameter	Sectors	Coefficient	95% LCL	95% UCL	P-value
GCIPL of OCT	Average	−3.455	−5.896	−1.014	0.009
	Superotemporal	−4.767	−7.592	−1.942	0.003
	Superior	−3.461	−6.021	− 0.901	0.014
	Superonasal	−5.311	−8.19	−2.433	0.001
	Inferonasal	−2.349	−7.199	2.501	0.578
	Inferior	−2.134	−6.211	1.943	0.522
	Inferotemporal	−3.027	−6.023	− 0.032	0.032
	SN + IN/ST + IT	−0.001	− 0.031	0.029	0.639
mRNFL of OCT	Average	−2.354	−4.136	−0.572	0.034
	Superotemporal	−3.665	−6.407	−0.923	0.026
	Superior	−4.455	−7.321	−1.589	0.008
	Superonasal	−2.546	−4.118	−0.973	0.007
	Inferonasal	0.000	−2.590	2.591	0.775
	Inferior	−1.182	−4.261	1.897	0.624
	Inferotemporal	−2.706	−5.414	0.002	0.132
	SN + IN/ST + IT	0.015	−0.016	0.045	0.632
GCC of OCT	Average	−5.809	−9.928	−1.691	0.017
	Superotemporal	−8.432	−13.613	−3.252	0.007
	Superior	−7.916	−13.221	−2.61	0.008
	Superonasal	−7.857	−12.041	−3.673	0.001
	Inferonasal	−2.349	−9.577	4.88	0.810
	Inferior	−3.316	−10.332	3.7	0.642
	Inferotemporal	−5.733	−10.939	−0.527	0.055
	SN + IN/ST + IT	0.008	−0.016	0.033	0.735
Mean thresholds of HFA 10–2	Mean Deviation	−2.089	−4.100	−0.077	0.069
	Superotemporal	−1.759	−4.173	0.656	0.231
	Superior	−4.302	−7.772	−0.833	0.045
	Superonasal	−4.437	−7.652	−1.223	0.020
	Inferonasal	0.780	−1.728	3.287	0.425
	Inferior	−0.606	−2.360	1.149	0.773
	Inferotemporal	−0.864	−2.433	0.706	0.026
	SN + IN/ST + IT	0.033	−0.104	0.169	0.083
Total deviation of HFA 10–2	Superotemporal	−1.511	−3.588	0.567	0.097
	Superior	−4.329	−7.861	− 0.797	0.051
	Superonasal	−4.823	−8.172	−1.475	0.018
	Inferonasal	0.356	−2.525	3.236	0.604
	Inferior	−0.282	−1.932	1.369	0.943
	Inferotemporal	−0.219	−1.012	0.573	0.569
	SN + IN/ST + IT	−0.890	−6.775	4.994	0.802

Coefficient represents the increase in the value of parameter in each sector when N/T of mfERG changes by 75th percentile from 25th percentile. All multivariable regression models were adjusted for age and spherical equivalent
N/T nasal to temporal amplitude ratio, mfERG multifocal electroretinogram, OCT Optical coherence tomopraphy, HFA 10–2 Humphrey Field Analyzer Program Central 10–2, IQR interquartile range (25th percentile – 75th percentile), LCL lower confidence limit, UCL upper confidence limit, GCIPL Ganglion cell-inner plexiform layer, SN Superonasal, IN Inferonasal, ST Superotemporal, IT Inferotemporal, mRNFL Macular retinal nerve fiber layer, GCC Ganglion cell complex

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ISSN: 1471-2415

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