Fig. 1

Image findings of the right eye before (a, b) and after four aflibercept intravitreal injections (c-g). a Fundus photograph shows an orange-red nodular lesion and hemorrhagic PED surrounded by subretinal hemorrhage in the macula. b OCT image shows tomographic notch sign (yellow arrow) and pachychoroid (red up-down arrow: 309 μm). c Subretinal hemorrhage is resolved and polypoidal lesions have improved. d OCT image shows disappearance of polypoidal lesion. e In early-phase ICGA image, polypoidal lesions (yellow arrows) are still present. Engorgement of choroidal vessels was found (red arrow). f Late-phase ICGA image depicts PHS (yellow arrow) in posterior fundus. OCT image at the site of PHS shows small RPE elevation (yellow arrow). g Late-phase ICGA image reveals PHS in peripheral fundus (yellow oval). OCT at this site shows small sharp-peaked RPE elevations (yellow arrow). h Fundus photograph shows no abnormality in the area where ICGA depicts PHS (yellow oval). PED: pigment epithelial detachment, OCT: optical coherence tomography, ICGA: indocyanine green angiography, PHS: punctate hyperfluorescent spots, RPE: retinal pigmented epithelium