Table 3 Potential treatments by neurotrophic keratopathy stage (rated as optimal in at least one stage)

Discontinue all preservative-containing topical medications

^a

^a

^a

 Topical preservative-free drops

^a

^a

^a

 Topical preservative-free gel drops or ointments

^a

^a

^a

 Autologous serum drops, human umbilical cord serum, platelet rich plasma

^a

^a

^a

 Recombinant human nerve growth factor (cenegermin)

^b

^a

^a

 Prophylactic topical preservative-free antibiotics (excluding aminoglycosides)

^a

^a

 Matrix metalloproteinases inhibitors

^b

^a

^a

 Corneal therapeutic contact lenses

^b

^a

^b

 Fresh-frozen self-retained amniotic membrane

^a

^a

 Punctal occlusion

^a

^a

^a

 Synthetic (cyanoacrylate) tissue adhesive

^a

 Tarsorrhaphy

^b

^a

 Amniotic membrane transplant

^b

^a

 Corneal neurotization

^b

^a