Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children

Bajtl, Dunja; Bjeloš, Mirjana; Bušić, Mladen; Križanović, Ana; Marković, Leon; Kuzmanović Elabjer, Biljana

doi:10.1186/s12886-021-02122-y

Table 1 Sexual differentiation of examined vascular parameters

From: Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children

Variable (measurement unit)	Layer	Male			Female			P Value^*
Variable (measurement unit)	Layer	Mean	25th percentile	75th percentile	Mean	25th percentile	75th percentile	P Value^*
EA (mm²)	RPCP	8.38	8.38	8.38	8.38	8.38	8.38	0.64
	SVP	8.38	8.38	8.38	8.38	8.38	8.38	0.16
	ICP	8.38	8.38	8.38	8.38	8.38	8.38	0.62
	DCP	8.38	8.38	8.38	8.38	8.38	8.38	0.08
	CC	8.38	8.38	8.38	8.38	8.38	8.38	0.09
	Choroid	8.38	8.38	8.38	8.38	8.38	8.38	0.40
	SVC	8.38	8.38	8.38	8.38	8.38	8.38	0.07
	DVC	8.38	8.38	8.38	8.38	8.38	8.38	0.23
	Ret	8.38	8.38	8.38	8.38	8.38	8.38	0.56
	Full	8.38	8.38	8.38	8.38	8.38	8.38	0.62
VA (mm²)	RPCP	3.44	2.89	3.94	3.32	2.64	3.65	0.38
	SVP	5.46	5.27	5.69	5.43	5.08	5.61	0.30
	ICP	5.53	5.37	5.63	5.45	5.17	5.60	0.31
	DCP	5.70	5.55	5.85	5.60	5.45	5.78	0.16
	CC	6.69	6.45	6.80	6.61	6.50	6.78	0.97
	Choroid	5.46	5.29	5.54	5.57	5.38	5.72	0.05
	SVC	5.04	4.87	5.33	4.97	4.52	5.20	0.15
	DVC	5.93	5.78	6.09	5.81	5.62	6.02	0.08
	Ret	5.43	5.14	5.62	5.20	4.94	5.49	0.03
	Full	5.72	5.53	5.78	5.51	5.37	5.74	0.04
VD (%)	RPCP	41.07	34.54	46.98	39.64	31.47	43.55	0.38
	SVP	65.12	62.91	67.91	64.84	60.59	66.95	0.31
	ICP	66.02	64.08	67.19	64.98	61.72	66.87	0.31
	DCP	68.02	66.20	69.84	66.81	65.10	69.03	0.16
	CC	79.86	76.98	81.13	78.87	77.61	80.88	0.97
	Choroid	65.17	63.09	66.09	66.53	64.27	68.21	0.05
	SVC	60.14	58.14	63.56	59.29	53.97	62.12	0.16
	DVC	70.76	68.93	72.67	69.38	67.06	71.87	0.08
	Ret	64.82	61.37	67.10	62.04	59.01	65.52	0.03
	Full	68.32	66.04	68.95	65.76	64.13	68.48	0.04
TNJ	RPCP	1196.00	948.50	1391.50	1114.00	831.50	1235.00	0.23
	SVP	1530.00	1486.50	1581.50	1516.00	1471.50	1564.00	0.33
	ICP	1763.00	1715.00	1802.50	1757.00	1695.50	1789.00	0.45
	DCP	1696.00	1653.50	1737.50	1692.00	1636.50	1737.00	0.69
	CC	1628.00	1596.50	1721.00	1658.00	1610.50	1742.00	0.23
	Choroid	1625.00	1594.00	1655.50	1602.00	1551.50	1674.00	0.59
	SVC	1494.00	1432.50	1589.50	1496.00	1381.00	1573.00	0.37
	DVC	1781.00	1733.00	1834.50	1762.00	1704.50	1807.00	0.11
	Ret	1781.00	1743.50	1858.00	1781.00	1699.50	1813.50	0.20
	Full	1910.00	1868.00	1930.50	1910.00	1875.50	1930.50	0.75
JD (mm²)	RPCP	142.73	113.20	166.04	132.95	99.22	147.37	0.23
	SVP	182.56	177.39	188.73	180.91	175.57	186.65	0.33
	ICP	210.38	204.65	215.09	209.68	202.33	213.47	0.46
	DCP	202.38	197.31	207.33	201.90	195.28	207.27	0.70
	CC	194.28	190.50	205.34	197.82	192.19	207.86	0.23
	Choroid	193.88	190.21	197.54	191.15	185.15	199.76	0.59
	SVC	178.31	170.97	189.70	178.49	164.78	187.71	0.39
	DVC	212.51	206.80	218.89	210.25	203.43	215.62	0.11
	Ret	212.60	208.03	221.72	212.51	202.81	216.42	0.20
	Full	227.89	222.92	230.37	227.95	223.78	230.39	0.76
TVL (mm)	RPCP	125.30	105.90	137.76	117.72	97.55	128.03	0.22
	SVP	152.15	148.52	154.93	151.45	148.23	153.68	0.31
	ICP	163.42	161.20	164.87	163.64	159.22	164.91	0.64
	DCP	159.53	156.21	161.72	159.00	155.86	161.49	0.48
	CC	159.86	158.32	163.56	162.00	159.23	164.14	0.29
	Choroid	157.13	154.26	158.96	156.45	153.39	159.96	0.91
	SVC	149.66	146.34	154.77	149.39	141.86	152.77	0.35
	DVC	164.29	161.98	166.37	163.34	161.11	165.04	0.10
	Ret	164.14	161.20	167.02	163.44	159.66	165.66	0.14
	Full	170.18	168.52	171.23	169.68	166.94	170.94	0.29
AVL (mm)	RPCP	0.73	0.40	1.01	0.56	0.30	0.76	0.17
	SVP	8.71	7.07	13.50	7.87	5.46	10.85	0.13
	ICP	10.11	7.04	16.57	9.11	7.09	13.54	0.54
	DCP	11.14	9.75	14.53	11.46	9.89	14.40	0.85
	CC	55.44	39.86	82.59	78.95	46.70	120.32	0.57
	Choroid	11.89	7.76	21.15	15.42	9.48	26.76	0.18
	SVC	7.57	4.60	9.56	6.36	3.89	7.99	0.11
	DVC	27.87	20.50	40.62	20.10	11.57	32.92	0.01
	Ret	7.20	5.21	12.51	5.89	4.70	9.14	0.13
	Full	28.09	16.19	49.45	18.63	13.44	31.18	0.04
TNEP	RPCP	734.00	598.50	878.00	778.00	655.50	931.00	0.36
	SVP	143.00	124.00	180.00	154.00	134.50	196.00	0.13
	ICP	148.00	131.50	179.00	162.00	126.50	199.00	0.41
	DCP	128.00	106.50	145.00	131.00	111.50	151.50	0.47
	CC	59.00	53.00	75.00	64.00	55.00	74.50	0.86
	Choroid	206.00	174.50	236.50	181.00	152.50	222.00	0.08
	SVC	180.00	149.50	237.50	196.00	171.00	304.00	0.08
	DVC	93.00	77.50	105.00	93.00	81.50	129.00	0.22
	Ret	171.00	144.00	219.00	204.00	165.50	276.00	0.03
	Full	133.00	109.50	167.00	162.00	126.50	198.50	0.07
L^**	RPCP	0.11	0.08	0.14	0.14	0.09	0.19	0.05
	SVP	0.03	0.02	0.04	0.03	0.03	0.04	0.46
	ICP	0.02	0.01	0.02	0.02	0.02	0.03	0.62
	DCP	0.03	0.03	0.03	0.03	0.03	0.04	0.45
	CC	0.01	0.01	0.01	0.01	0.01	0.01	0.98
	Choroid	0.01	0.01	0.01	0.01	0.01	0.01	0.18
	SVC	0.04	0.03	0.05	0.04	0.04	0.05	0.21
	DVC	0.02	0.02	0.02	0.02	0.02	0.03	0.19
	Ret	0.02	0.02	0.02	0.02	0.02	0.03	0.10
	Full	0.0107	0.0093	0.0126	0.0122	0.0111	0.0132	0.026
FAZ area (mm²)	RPCP	1.13	0.72	1.42	1.27	0.93	1.61	0.10
	SVP	0.55	0.36	0.67	0.52	0.41	0.64	0.99
	ICP	0.22	0.13	0.29	0.23	0.12	0.32	0.76
	DCP	0.52	0.43	0.59	0.53	0.38	0.65	0.64
	SVC	0.62	0.44	0.78	0.65	0.45	0.75	0.86
	DVC	0.26	0.15	0.35	0.30	0.17	0.36	0.48
	Ret	0.28	0.17	0.33	0.31	0.17	0.39	0.36
VDI (μm)	RPCP	27.62	26.90	28.72	27.74	26.37	29.05	0.84
	SVP	35.90	34.56	36.95	35.68	34.03	36.57	0.41
	ICP	33.66	33.00	34.22	33.28	32.62	34.15	0.31
	DCP	35.66	34.44	37.33	35.21	34.18	36.19	0.27
	CC	41.99	39.20	42.82	41.50	39.63	42.28	0.79
	Choroid	34.60	33.69	35.44	35.62	34.43	36.05	0.01
	SVC	33.75	32.72	34.61	33.08	31.60	34.23	0.14
	DVC	35.91	35.01	37.48	35.39	34.66	36.67	0.19
	Ret	32.68	31.13	34.22	31.82	31.09	33.02	0.05
	Full	33.42	32.82	33.99	32.47	31.91	33.66	0.04
T	RPCP	11.14	6.82	14.84	8.98	5.57	11.54	0.15
	SVP	96.56	78.10	148.27	85.68	60.94	119.11	0.11
	ICP	114.13	83.46	193.42	106.17	83.25	157.75	0.49
	DCP	128.86	111.69	168.55	131.57	113.74	163.36	0.92
	CC	612.67	421.25	925.50	835.50	499.96	1251.00	0.48
	Choroid	139.77	90.53	240.73	173.00	108.25	309.33	0.20
	SVC	80.90	53.69	105.72	71.50	44.88	89.21	0.15
	DVC	323.50	232.81	453.88	224.75	129.56	365.90	0.01
	Ret	87.26	63.10	148.11	71.36	58.17	110.36	0.15
	Full	341.67	196.35	568.79	229.67	161.56	370.33	0.04
Macular thickness (μm)	CMT	252.00	239.00	267.50	256.00	240.50	265.00	0.76
	FoT	204.00	197.50	213.00	207.00	199.50	216.50	0.32
	PTT	328.00	314.00	334.50	324.00	319.00	333.00	0.89
	PNT	335.00	324.50	347.00	336.00	327.00	344.50	0.78
	PST	338.00	326.50	348.00	339.00	332.50	347.50	0.53
	PIT	339.00	325.50	344.00	334.00	327.50	343.00	0.52
Macular volume (μl)	CMV	0.20	0.19	0.21	0.20	0.19	0.21	0.94
	PTV	0.52	0.49	0.52	0.51	0.50	0.52	0.69
	PNV	0.53	0.51	0.54	0.53	0.51	0.54	0.71
	PSV	0.53	0.51	0.55	0.53	0.52	0.55	0.46
	PIV	0.53	0.51	0.54	0.53	0.51	0.54	0.66

EA explant area, VA vessels area, VD vessels density, TNJ total number of junctions, JD junctions density, TVL total vessel length, AVL average vessel length, TNEP total number of endpoints, L mean lacunarity, FAZ foveal avascular zone, VDI vessel diameter index, T tortuosity, RPCP radial peripapillary capillary plexus, SVP superficial vascular plexus, ICP intermediate vascular plexus, DCP deep capillary plexus, SVC superficial vascular complex, DVC deep vascular complex, CC choriocapillaris, Ret retina, Full chorioretina, CMT central macular thickness, CMV central macular volume, FoT foveolar thickness, PTT parafoveal temporal thickness, PTV parafoveal temporal volume, PNT parafoveal nasal thickness, PNV parafoveal nasal volume, PST parafoveal superior thickness, PSV parafoveal superior volume, PIT parafoveal inferior thickness, PIV parafoveal inferior volume
*Statistical significance was measured using Mann-Whitney U Test. Bolded values denote statistical significance at the level P < 0.05
**The chorioretinal lacunarity value is presented with four decimal places due to better observation of statistically significant differences

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