Rare single nucleotide variants in COL5A1 promoter do not play a major role in keratoconus susceptibility associated with rs1536482

Table 5 Minor Allele Frequency in Keratoconus Patients and Control Groups

dbSNP identi-fication number	Minor allele frequency				Keratoconus vs. main control group		Keratoconus vs. combined control group
dbSNP identi-fication number	Keratoconus group	Main control group	Additional control group	Combined control group	p-value	OR	p-value	OR
rs1536482	0.393	0.278	0.307	0.298	0.0016	1.68	0.0016	1.53
rs2721051	0.147	0.059	0.075	0.070	0.0001	2.76	4.60⁻⁰⁵	2.29
rs1324183	0.290	0.200	0.157^a	0.169	0.0058	1.63	4.00⁻⁰⁶	2.01

ISSN: 1471-2415