Fig. 1

Original and processed images of superficial (upper row: A to F) and deep (lower row: G to L) capillary plexus of a 25-year-old patient, 14 months after plaque radiation. Figure A and G represents the original superficial capillary plexus (SCP) and deep capillary plexus (DCP) images, respectively. Figure B and H illustrates color-coded flow density map of the macula showing the SCP and DCP, respectively. (warmer colours indicate greater flow). Vessel density maps that are binarized images of SCP and DCP and produced after applying denoising and preprocessing algorithms on the original images have been shown in Figures C and I, respectively. Figures D and J show the skeletonization map-a series of connected lines with the thickness of one pixel that represents the route of vessels- in SCP and DCP, respectively. For calculation of the parafoveal vascular and skeleton density, two concentric circles were centered on the fovea with diameters of 1 mm and 3 mm. Figures E and K represent SCP and DCP parafoveal vascular density map and figures F and L show the skeletonization map in corresponding images