Fig. 2
From: Ophthalmic Rosai–Dorfman disease: a multi-centre comprehensive study
A Aggregates of lymphocytic infiltrate surrounded by histiocytes in a patient having orbital RDD (original magnification × 100, Hematoxylin & Eosin). B Higher power of the collection of lymphocytes with surrounding large histiocytes (original magnification × 400, Hematoxylin & Eosin). C Immunohistochemical staining by S-100 delineating many macrophages engulfing lymphocytes (emperipolesis & lymphocytophagocytosis) for a patient having scleral RDD (original magnification × 400). D Another histopathological photo from a patient with orbital RDD showing a typical histiocyte with clear emperipolesis (original magnification × 400 S-100-stain)