Fig. 1

Representative cases in responsive groups (A – I) and refractory groups (J – R). A, J Fluorescein angiography (FA) images at 1 min. B, K FA images at 5 min. Large and small squares demarcated by yellow dashed line denote the locations of perifoveal and parafoveal images, respectively. C, L Binarized FA images of perifoveal area at 1 min. The yellow crosses indicate the location of the foveal centers. D, M Binarized FA images of the perifoveal area at 5 min. E, N The perifoveal images after subtracting the image at 1-min from the image at 5-min. Mean gray value over perifoveal region was 13.9 for the responsive case and 63.7 for the refractory case. F, O Binarized FA images of parafoveal area at 1 min. G, P Binarized FA images of parafoveal area at 5 min. H, Q Parafoveal images after subtracting the image at 1-min from the image at 5-min. Mean gray value over the parafoveal image was 8.2 in the responsive case and 48.6 in the refractory case. I, R Pre-treatment coherence tomography (OCT) images with the central retinal thickness (CRT) of 594 μm in the responsive case and 655 μm in the refractory case