Fig. 3

Representative fluorescein angiography (FA) images in responsive group with large non-perfusion area and FA leakage outside the macula. A FA images at 1 min. B FA images at 5 min. The large and small squares demarcated by yellow dashed line denote the locations of perifoveal and parafoveal images, respectively. C Binarized FA images of the perifoveal area at 1 min. The yellow cross indicates the location of the foveal centers. D Binarized FA images of the perifoveal area at 5 min. E The perifoveal images after subtracting the image at 1-min from the image at 5-min. The mean gray value over the perifoveal region was 13.6. F Binarized FA images of the parafoveal area at 1 min. G Binarized FA images of the parafoveal area at 5 min. H Parafoveal images after subtracting the image at 1-min from the image at 5-min. The mean gray value over the parafoveal image was 14.5. I Pre-treatment coherence tomography (OCT) images with a central retinal thickness (CRT) of 702 μm