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Table 2 Characteristics of studies assessing diagnostic ability of β-PPA

From: Prevalence and diagnostic ability of β-zone parapapillary atrophy in open-angle glaucoma: a systematic review and meta-analysis

Study Numbers of POAG Numbers of healthy controls Index test TP FP FN TN
Jonas et al. [2, 24] 312 125 Clinical diagnosis 208 25 104 100
Budde and Jonas [21] 501 481 Clinical diagnosis 312 121 189 360
Emdadi et al. [20] 29 29 Clinical diagnosis 13 2 16 27
Sugiyama [18] 207 11,727 Glaucomatous optic neuropathy 164 3319 43 8408
Pan et al. [14] 45 42 Clinical diagnosis 22 8 23 34
Wu et al. [13] 27 32 Clinical diagnosis 21 7 6 25
Xu et al. [12] 93 3910 Clinical diagnosis 64 938 29 2972
Hayashi et al. [9] 100 100 Clinical diagnosis 84 63 16 36
Sullivan-Mee et al. [7] 63 48 Clinical diagnosis 48 18 15 30
Miki et al. [3] 50 43 Clinical diagnosis 47 18 3 25
Mataki et al. [5] 84 2129 Clinical diagnosis 65 1165 19 964
Skaat et al. [6] 801 1149 Glaucomatous optic neuropathy 618 716 183 433
Lee et al.[33] 88 88 Clinical diagnosis 88 55 0 33
Sayed et al.[35]
(SD-OCT)
100 100 Clinical diagnosis 90 69 10 31
  1. Clinical diagnosis means that ‘POAG’ & ‘healthy controls’ were diagnosed not only by morphology of the optic disc but also by other clinical symptoms, including visual field, IOP and thickness of optic nerve fibre layer. Glaucomatous optic neuropathy means that the researchers only studied the morphology of glaucomatous optic discs
  2. Abbreviations: FN false negative, FP false positive, TN true negative, TP true positive
  3. Sensitivity indicates that the TP rate is equivalent to TP/(TP + FN). Specificity indicates that the TN rate is equivalent to TN/(TN + FP)