Fig. 4
From: Novel SOX2 mutation in autosomal dominant cataract-microcornea syndrome
Mutations and predicted crystal structures of SOX2 protein. A Location of the mutations with respect to the topological model of the SOX2 polypeptide. B Predicted crystal structures of wild-type (left) and mutant (right) SOX2 protein. SOX family member contains a highly conserved HMG domain (in green/purple), with NLSs positioned within the extremities of the HMG domain