Fig. 6
From: A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
The effect of the 7-mer on VEGF-induced microvessel sprouting of aortic ring and corneal neovascularization. a Rat aortic ring assay. Photomicrographs of aortic ring explants after treatment for 5 days (magnification × 40). Sprouting was evaluated on a scale from 0 (no sprouts) to 3 (profuse sprouting). There was no sprouting of vessels from ex vivo aortic rings embedded in Matrigel without LSGS or VEGF. b The 7-mer inhibits VEGF-induced corneal angiogenesis in C57BL/6 mice. Representative corneas and final scoring determining the number of positive corneas per total implantations. Arrows indicate the corneal region near to the VEGF/vehicle or VEGF/7-mer pellet