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Table 1 Clinical characteristics of patients with different surgical procedures

From: Glaucoma and risk factors three years after congenital cataract surgery

  Group 1 Group 2 Group 3 P-value 1 P-value 2 P-value 3 * P-value 1 * P-value 2 * P-value 3
Eyes, n 111 85 63       
Right eye, n 57 43 34       
Unilateral cataract, n (%) 61 (55.0) 22 (25.9) 7(11.1)  < 0.001  < 0.001 0.025    
IOL implantation, n
 In-the-bag 109 68       
 Sulcus 2 17       
History of prematurity, n (%) 7 (6.3) 13 (15.3) 4 (6.4) 0.039 1.000 0.092 0.287 0.518 0.175
FHCC, n (%) 7 (6.3) 12 (14.1) 8 (12.7) 0.067 0.149 0.803 0.525 0.838 0.621
PFV, n (%) 16 (14.4) 17(20.0) 10(15.9) 0.300 0.795 0.520 0.015 0.037 0.566
Age at surgery (months), Median (IQR)
 Primary surgery 34.0 (15.0–46.0) 4.0 (3.0–5.0) 3.0 (2.0–4.0)  < 0.001  < 0.001 0.008  < 0.001  < 0.001 0.045
 Secondary surgery 34.0 (24.0–37.0)       
Follow-up (months), Median (IQR) 39.0 (29.0–53.0) 50.0 (44.0–62.0) 35.0 (27.0–44.0)  < 0.001 0.050  < 0.001  < 0.001 0.030  < 0.001
IOP (mmHg), Mean ± SD
 Baseline 1 12.9 ± 3.1 12.4 ± 2.6 10.8 ± 2.7 0.176  < 0.001  < 0.001 0.292  < 0.001 0.002
 Baseline 2 13.9 ± 2.7       
 Latest follow-up 14.6 ± 3.1 16.8 ± 4.0 14.4 ± 3.1  < 0.001 0.635  < 0.001 0.001 0.503  < 0.001
Pre-op HCD (mm), Mean ± SD 10.4 ± 0.6 9.4 ± 0.7 9.4 ± 1.0  < 0.001  < 0.001 0.982  < 0.001  < 0.001 0.903
Pre-op CCT (μm), Mean ± SD 541.1 ± 44.5 564.8 ± 49.7 574.6 ± 46.9 0.001  < 0.001 0.230 0.012 0.002 0.359
Pre-op ACD (mm), Mean ± SD 2.9 ± 0.6 2.3 ± 0.4 2.4 ± 0.5  < 0.001  < 0.001 0.782  < 0.001  < 0.001 0.874
Pre-op LT (mm), Mean ± SD 3.7 ± 0.9 3.4 ± 1.0 3.1 ± 1.1 0.185 0.003 0.095 0.337 0.070 0.218
Pre-op AL (mm), Mean ± SD 21.5 ± 2.0 18.7 ± 1.1 17.9 ± 1.5  < 0.001  < 0.001  < 0.001  < 0.001  < 0.001 0.006
Glaucoma, n (%) 0 (0) 6 (7.1) 4 (6.3) 0.006 0.016 1.000 0.025 0.144 0.894
Glaucoma suspect, n (%) 0 (0) 10 (11.8) 1 (1.6)  < 0.001 0.362 0.025 0.010 0.304 0.058
Glaucoma-related adverse events, n (%) 0 (0) 16 (18.8) 5 (7.9)  < 0.001 0.006 0.061  < 0.001 0.070 0.127
Steroid-induced ocular hypertension, n (%) 5 (4.5) 17 (20.0) 5 (7.9) 0.001 0.499 0.041 0.009 0.211 0.038
  1. P-value 1: Group 1 vs Group 2; P-value 2: Group 1 vs Group 3; P-value 3: Group 2 vs Group 3
  2. * P values adjusted for unilateral cataract difference by generalised estimating equation
  3. Baseline 1, primary preoperative IOP; Baseline 2, secondary preoperative IOP
  4. IOL Intraocular lens, FHCC Family history of congenital cataract, PFV Persistent fetal vasculature, IQR Interquartile range, IOP Intraocular pressure, Pre-op Preoperative, HCD Horizontal corneal diameter, CCT Central corneal thickness, ACD Anterior chamber depth, LT Lens thickness, AL Axial length