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Table 4 Adjusted comparison of mean change from baseline to month-6 in different study variables according to baseline diagnosis and according to external limiting membrane (ELM) status. Statistical significance was assessed using the analysis of covariance (ANCOVA)

From: Optical coherence tomography biomarkers in patients with macular edema secondary to retinal vein occlusion treated with dexamethasone implant

  Diagnosis P
CRVO (n = 15) BRVO (n = 42)
BCVAa
 Mean (SEM) −3.8 (6.3) 4.0 (3.6) 0.2930
 95% CI −16.4 to 8.8 −3.3 to 11.4
CRTb, μm
 Mean (SEM) −200.2 (74.1) − 255.1 (43.1) 0.5338
 95% CI − 349.1 to − 51.3 − 341.7 to − 168.5  
CSTc, mm3
 Mean (SEM) 5.5 (19.3) 0.4 (11.2) 0.8218
 95% CI −33.3 to 44.4 − 22.2 to 23.0
SRF*d, μ
 Mean (SEM) −46.6 (42.3) − 49.2 (24.2) 0.9583
 95% CI − 133.3 to 40.2 − 98.8 to 0.32
Cyst volumee, μm3
 Mean (SEM) −71.0 (78.7) −199.3 (44.9) 0.1771
 95% CI − 232.1 to 90.1 − 291.3 to − 107.3
  Treatment Status  
Naïve (n = 31) Previously treated (n = 27) P
BCVAa
 Mean (SEM) 4.4 (4.5) −1.0 (4.9) 0.4522
 95% CI −4.6 to 13.4 −10.9 to 9.0
CRTb, μm
 Mean (SEM) − 308.4 (58.3) − 165.5 (57.7) 0.0988
 95% CI − 417.5 to −199.3 − 281.3 to − 49.5
CSTc, mm3
 Mean (SEM) −2.4 (14.2) 6.3 (15.1) 0.6974
 95% CI −30.8 to 26.1 −23.9 to 36.5
SRF*d, μ
 Mean (SEM) −22.7 (26.9) −87.3 (33.2) 0.1498
 95% CI −77.9 to 32.3 −155.3 to 24.7
Cyst volumee, μm3
 Mean (SEM) − 186.0 (50.0) −136.8 (61.7) 0.5482
 95% CI − 288.3 to −83.6 − 263.2 to − 10.4
  ELM status  
Non-disrupted Partially disrupted Disrupted p
BCVAa
 Mean (SEM) −3.5 (6.8) 4.6 (5.0) 2.3 (5.6) 0.2651
 95% CI −17.2 to 10.1 −5.4 to 14.7 −8.9 to 13.5
CRTb, μm
 Mean (SEM) − 273.6 (80.6) − 277.3 (59.3) − 175.3 (66.1) 0.2783
 95% CI − 435.6 to − 111.7 −396.8 to − 158.1 − 308.2 to − 42.3
CSTc, μm
 Mean (SEM) 8.6 (21.0) −7.3 (15.4) 8.0 (17.2) 0.5796
 95% CI −33.5 to 50.9 −38.3 to 23.8 −26.6 to 42.7
SRF*d, μ
 Mean (SEM) −19.0 (48.7) −55.1 (29.2) −57.7 (41.9) 0.6068
 95% CI − 119.0 to 80.9 −115.1 to 4.9 −143.7 to 28.4
Cyst volumee, μm3
 Mean (SEM) −173.5 (90.6) − 156.4 (54.4) −181.6 (78.0) 0.8661
 95% CI − 359.4 to 12.4 −268.0 to −44.8 −341.6 to − 21.6
  1. Bonferroni correction was applied to the pairwise comparisons
  2. Model 1: “Diagnosis” as factor and age, sex, duration of macular edema, treatment status (naïve or previously treated), type of macular edema (ME), and ELM status as covariates
  3. Model 2: “Treatment status” (naïve or previously treated) as factor and age, sex, duration of macular edema, diagnosis, type of macular edema (ME), and ELM status as covariates
  4. Model 3: “ELM status” as factor and age, sex, duration of RVO-ME, treatment status (naïve or previously treated), type ME, and diagnosis as covariates
  5. BRVO Branch retinal vein occlusion, CRVO Central retinal vein occlusion, Other: Uveitis and Irvine-gass, BCVA Best corrected visual acuity, SEM Standard error of the mean, CI Confidence interval, CRT Central retinal thickness, MV Macular volume
  6. aAlso adjusted by baseline BCVA
  7. bAlso adjusted by baseline CRT
  8. cAlso adjusted by baseline CST
  9. dAlso adjusted by baseline SRF
  10. eAlso adjusted by baseline volume cysts
  11. *In the yes with serous retinal detachment (35 eyes). This variable was not adjusted by type of edema