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Table 4 Adjusted comparison of mean change from baseline to month-6 in different study variables according to baseline diagnosis and according to external limiting membrane (ELM) status. Statistical significance was assessed using the analysis of covariance (ANCOVA)

From: Optical coherence tomography biomarkers in patients with macular edema secondary to retinal vein occlusion treated with dexamethasone implant

 

Diagnosis

P

CRVO (n = 15)

BRVO (n = 42)

BCVAa

 Mean (SEM)

−3.8 (6.3)

4.0 (3.6)

0.2930

 95% CI

−16.4 to 8.8

−3.3 to 11.4

CRTb, μm

 Mean (SEM)

−200.2 (74.1)

− 255.1 (43.1)

0.5338

 95% CI

− 349.1 to − 51.3

− 341.7 to − 168.5

 

CSTc, mm3

 Mean (SEM)

5.5 (19.3)

0.4 (11.2)

0.8218

 95% CI

−33.3 to 44.4

− 22.2 to 23.0

SRF*d, μ

 Mean (SEM)

−46.6 (42.3)

− 49.2 (24.2)

0.9583

 95% CI

− 133.3 to 40.2

− 98.8 to 0.32

Cyst volumee, μm3

 Mean (SEM)

−71.0 (78.7)

−199.3 (44.9)

0.1771

 95% CI

− 232.1 to 90.1

− 291.3 to − 107.3

 

Treatment Status

 

Naïve (n = 31)

Previously treated (n = 27)

P

BCVAa

 Mean (SEM)

4.4 (4.5)

−1.0 (4.9)

0.4522

 95% CI

−4.6 to 13.4

−10.9 to 9.0

CRTb, μm

 Mean (SEM)

− 308.4 (58.3)

− 165.5 (57.7)

0.0988

 95% CI

− 417.5 to −199.3

− 281.3 to − 49.5

CSTc, mm3

 Mean (SEM)

−2.4 (14.2)

6.3 (15.1)

0.6974

 95% CI

−30.8 to 26.1

−23.9 to 36.5

SRF*d, μ

 Mean (SEM)

−22.7 (26.9)

−87.3 (33.2)

0.1498

 95% CI

−77.9 to 32.3

−155.3 to 24.7

Cyst volumee, μm3

 Mean (SEM)

− 186.0 (50.0)

−136.8 (61.7)

0.5482

 95% CI

− 288.3 to −83.6

− 263.2 to − 10.4

 

ELM status

 

Non-disrupted

Partially disrupted

Disrupted

p

BCVAa

 Mean (SEM)

−3.5 (6.8)

4.6 (5.0)

2.3 (5.6)

0.2651

 95% CI

−17.2 to 10.1

−5.4 to 14.7

−8.9 to 13.5

CRTb, μm

 Mean (SEM)

− 273.6 (80.6)

− 277.3 (59.3)

− 175.3 (66.1)

0.2783

 95% CI

− 435.6 to − 111.7

−396.8 to − 158.1

− 308.2 to − 42.3

CSTc, μm

 Mean (SEM)

8.6 (21.0)

−7.3 (15.4)

8.0 (17.2)

0.5796

 95% CI

−33.5 to 50.9

−38.3 to 23.8

−26.6 to 42.7

SRF*d, μ

 Mean (SEM)

−19.0 (48.7)

−55.1 (29.2)

−57.7 (41.9)

0.6068

 95% CI

− 119.0 to 80.9

−115.1 to 4.9

−143.7 to 28.4

Cyst volumee, μm3

 Mean (SEM)

−173.5 (90.6)

− 156.4 (54.4)

−181.6 (78.0)

0.8661

 95% CI

− 359.4 to 12.4

−268.0 to −44.8

−341.6 to − 21.6

  1. Bonferroni correction was applied to the pairwise comparisons
  2. Model 1: “Diagnosis” as factor and age, sex, duration of macular edema, treatment status (naïve or previously treated), type of macular edema (ME), and ELM status as covariates
  3. Model 2: “Treatment status” (naïve or previously treated) as factor and age, sex, duration of macular edema, diagnosis, type of macular edema (ME), and ELM status as covariates
  4. Model 3: “ELM status” as factor and age, sex, duration of RVO-ME, treatment status (naïve or previously treated), type ME, and diagnosis as covariates
  5. BRVO Branch retinal vein occlusion, CRVO Central retinal vein occlusion, Other: Uveitis and Irvine-gass, BCVA Best corrected visual acuity, SEM Standard error of the mean, CI Confidence interval, CRT Central retinal thickness, MV Macular volume
  6. aAlso adjusted by baseline BCVA
  7. bAlso adjusted by baseline CRT
  8. cAlso adjusted by baseline CST
  9. dAlso adjusted by baseline SRF
  10. eAlso adjusted by baseline volume cysts
  11. *In the yes with serous retinal detachment (35 eyes). This variable was not adjusted by type of edema
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BMC Ophthalmology

ISSN: 1471-2415

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