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Table 5 Overview of optical coherence tomography (OCT) biomarkers over the course of the study. Statistical significance was calculated using the Chi-squared test

From: Optical coherence tomography biomarkers in patients with macular edema secondary to retinal vein occlusion treated with dexamethasone implant

  Overall (n = 57)
Baseline Month 2 Month 4 Month 6 p
DRIL, n (%)
 No 23 (40.4) 25 (43.9) 25 (48.1) 27 (47.4) 0.8365
 Yes 34 (59.6) 32 (56.1) 27 (51.9) 30 (52.6)
HRF, n (%)
 < 10 16 (28.1) 32 (56.1) 25 (48.1) 24 (42.1) 0.0851
 10–20 23 (40.4) 13 (22.8) 12 (23.1) 15 (26.3)
 > 20 18 (31.6) 12 (21.1) 15 (28.8) 18 (31.6)
Cyst, n (%)
 No Cysts 0 (0.0) 31 (54.4) 10 (19.2) 20 (35.1) < 0.0001
 < 100 μm3 2 (3.6) 0 (0.0) 0 (0.0) 0 (0.0)
 100–200 μm3 12 (21.4) 7 (12.3) 4 (7.7) 4 (7.0)
 > 200 μm3 42 (75.0) 19 (33.3) 38 (73.1) 33 (57.9)
ELM status, n (%)
 Non-disrupted 13 (22.8) 10 (17.9) 8 (15.4) 15 (26.8) 0.8122
 Partially disrupted 24 (42.1) 28 (50.0) 25 (48.1) 24 (42.9)
 Disrupted 20 (35.1) 18 (32.1) 19 (36.5) 17 (30.4)
  CRVO (n = 15)
Baseline Month 2 Month 4 Month 6 p
DRIL, n (%)
 No 5 (33.3) 2 (13.3) 4 (30.8) 4 (26.7) 0.6078
 Yes 10 (66.7) 13 (86.7) 9 (69.2) 11 (73.3)
HRF, n (%)
 < 10 3 (20.0) 9 (60.0) 5 (38.5) 9 (60.0) 0.0028
 10–20 11 (73.3) 4 (26.7) 2 (15.4) 2 (13.3)
 > 20 1 (6.7) 2 (13.3) 6 (46.29 4826.7)
Cyst, n (%)
 No Cysts 0 (0.0) 9 (60.0) 2 (15.4) 5 (33.3) 0.0016
 < 100 μm3 1 (6.7) 0 (0.0) 0 (0.0) 0 (0.0)
 100–200 μm3 5 (33.3) 0 (0.0) 0 (0.0) 1 (6.7)
 > 200 μm3 9 (60.0) 6840.0) 11 (84.6) 9 (60.0)
ELM status, n (%)
 Non-disrupted 2 (13.3) 3 (21.4) 2 (15.4) 3 (20.0) 0.9950
 Partially disrupted 6 (40.0) 5 (35.7) 6 (46.2) 6 (40.0)
 Disrupted 7 (46.7) 6 (42.9) 5 (38.5) 6 (40.0)
  BRVO (n = 42)
Baseline Month 2 Month 4 Month 6 p
DRIL, n (%)
 No 18 (42.9) 23 (54.8) 21 (53.8) 23 (54.8) 0.6370
 Yes 24 (57.1) 19 (45.2) 18 (46.2) 19 (45.2)
HRF, n (%)
 < 10 13 (31.0) 23 (54.8) 20 (51.3) 15 (35.7) 0.2755
 10–20 12 (28.6) 9 (21.4) 10 (25.6) 13,831.0)
 > 20 17 (40.5) 10 (23.8) 9 (23.1) 14 (33.3)
Cyst, n (%)
 No Cysts 0 (0.0) 22 (52.4) 8 (20.5) 15 (35.7) < 0.0001
 < 100 μm3 1 (2.4) 0 (0.0) 0 (0.0) 0 (0.0)
 100–200 μm3 7 (17.1) 7 (16.7) 4 (10.3) 3 (7.1)
 > 200 μm3 33 (80.5) 13 (31.0) 27 (69.2) 24 (57.1)
ELM status, n (%)
 Non-disrupted 11 (26.2) 7 (16.7) 6 (15.4) 12 (29.3) 0.6724
 Partially disrupted 18 (42.9) 23 (54.8) 19 (48.7) 18 (43.9)
 Disrupted 13 (31.0) 12 (28.6) 14 (35.9) 11 (26.8)
  1. RVO retinal vein occlusion, DRIL Disorganization od inner retinal layers, HRF Hyperreflective foci, CRVO Central retinal vein occlusion, BRVO Branch retinal vein occlusion