Table 1 Main characteristics of the included studies in the meta-analysis
From: The efficacy of XEN gel stent implantation in glaucoma: a systematic review and meta-analysis
First Author | Publish Year | Country | Study design | Eyes included | Male/Female | Age (Mean ± SD) | Surgical Implantation | Follow-up | JADA/NOS score |
|---|---|---|---|---|---|---|---|---|---|
Sheybani, A [5] | 2015 | US | Prospective | 37 | 14/23 | 69.6 ± 7.7 | phaco-XEN | 12 m | 1 |
Pérez-Torregrosa, V. T [70] | 2016 | Spain | Prospective | 30 | 5/13 | 76 ± 5.85 | phaco-XEN | 12 m | 1 |
Sheybani, A [81] | 2016 | US | Prospective | 49 | 20/29 | 64.3 | XEN | 12 m | 1 |
Fea, A. M [29] | 2017 | Italy | Prospective | 12 | 5/6 | 71.3 ± 10 | XEN | 12 m | 1 |
Galal, A [33] | 2017 | Germany | Prospective | 13 | 6/4 | 73.1 ± 10 | phaco-XEN | 12 m | 1 |
Grover, D [37] | 2017 | US | Prospective | 65 | 30/35 | 70 ± 12.3 | XEN | 12 m | 0 |
Hengerer, F. H [41] | 2017 | Germany | Retrospective | 242 | 100/142 | 67.6 ± 13.6 | XEN; phaco-XEN | 12 m | 5 |
Ilveskoski, L [47] | 2017 | Finland | Retrospective | 10 | 4/6 | 77.4 ± 5.7 | XEN | 6 m | / |
Olate-Pérez, Á. [66] | 2017 | Spain | Prospective | 30 | 5/13 | 76 ± 5.85 | phaco-XEN | 12 m | 1 |
Ozal, S.A [69] | 2017 | Turkey | Retrospective | 15 | 10/5 | 63.6 ± 13.3 | XEN; phaco-XEN | 12 m | / |
Schlenker, M. B [79] | 2017 | Canada | Retrospective | 354 | 176/178 | 66.4 | XEN; TB | 36 m | 7 |
Arnljots, TS [17] | 2018 | Sweden | Retrospective | 19 | 7/12 | 74.2 ± 8.4 | XEN; phaco-XEN | 12 m | / |
De Gregorio, A [26] | 2018 | Italy | Prospective | 41 | 13/20 | 74 ± 7.1 | phaco-XEN | 12 m | 0 |
Hengerer, F. H [40] | 2018 | Germany | Retrospective | 110 | 46/64 | 69.6 ± 13.7 | XEN | 12 m | 5 |
Hohberger, B [42] | 2018 | Germany | Retrospective | 111 | 64/47 | 68 ± 14 | XEN | 6 m | |
Karimi, A [49] | 2018 | UK | Retrospective | 17 | 9/8 | 76.1 | XEN | 12 m | |
Karimi, A [50] | 2018 | UK | Retrospective | 259 | 144/115 | 74.8 | XEN; phaco-XEN | 18 m | |
Mansouri, K [59] | 2018 | Switzerland | Prospective | 110 | 24/61 | 74.8 ± 9.4 | XEN | 12 m | 1 |
Mansouri, K [60] | 2018 | Switzerland | Prospective | 149 | 32/81 | 74.4 ± 9.4 | XEN; phaco-XEN | 12 m | 1 |
Sng, C. C [83] | 2018 | UK | Prospective | 24 | 9/15 | 45.3 ± 18.1 | XEN | 12 m | 0 |
Tan, S. Z [85] | 2018 | UK | Retrospective | 43 | 18/21 | 70.1 ± 13.8 | XEN | 12 m | |
Widder, R. A [91] | 2018 | Germany | Retrospective | 261 | 92/141 | 73 ± 11 | XEN; phaco-XEN | 18 m | |
Arad, T [16] | 2019 | Germany | Retrospective | 10 | 4/6 | 6.4 ± 4.7 | XEN | 24 m | |
Gillmann, K [34] | 2019 | Switzerland | Prospective | 110 | 24/61 | 74.8 ± 9.4 | XEN; phaco-XEN | 24 m | 1 |
Heidinger, A [38] | 2019 | Austria | Retrospective | 199 | 84/115 | 74.8 ± 10.5 | XEN | 18 m | |
Hengerer, F. H [39] | 2019 | Germany | Retrospective | 148 | 89/59 | 68.4 ± 13.9 | XEN | 12 m | |
Ibáñez-Muñoz, A [45] | 2019 | Spain | Retrospective | 21 | 13/7 | 80.9 ± 8.1 | XEN; phaco-XEN | 12 m | |
Kalina, AG [48] | 2019 | USA | Prospective | 47 | 14/28 | 78.15 ± 8.55 | XEN; phaco-XEN | 12 m | 1 |
Laroche, D [52] | 2019 | US | Retrospective | 12 | - | - | XEN | 12 m | |
Lenzhofer, M [54] | 2019 | AustriaTalbel | Prospective | 64 | 35/29 | - | XEN | 48 m | 1 |
Lenzhofer, M [55] | 2019 | Austria | Prospective | 137 | 67/70 | 75.2 ± 7.0 | XEN; phaco-XEN | 24 m | 1 |
Lenzhofer, M [56] | 2019 | Austria | Prospective | 66 | 28/38 | 72.2 ± 12.5 | XEN; phaco-XEN | 12 m | 0 |
Mansouri, K [58] | 2019 | Switzerland | Prospective | 149 | 32/81 | 74.4 ± 9.4 | XEN; phaco-XEN | 24 m | 1 |
Marcos Parra, M.T [61] | 2019 | Spain | Retrospective | 121 | 59/62 | 71.2 ± 11.7 | XEN; phaco-XEN; TB | 12 m | |
Marques, RE [62] | 2019 | Portugal | Retrospective | 60 | 26/34 | 73 | XEN; phaco-XEN | 6 m | |
Midha, N [64] | 2019 | Switzerland | Prospective | 149 | 63/70 | 74.4 ± 9.6 | XEN; phaco-XEN | 24 m | 1 |
Qureshi, A [72] | 2019 | UK | Retrospective | 37 | - | 45.97 ± 15.24 | XEN | 12 m | |
Reitsamer, H [75] | 2019 | Austria | Prospective | 161 | 90/95 | 71.8 ± 10.5 | XEN; phaco-XEN | 24 m | 1 |
Smith, M [82] | 2019 | UK | Retrospective | 68 | 35/33 | 76 ± 10 | XEN | 12 m | |
Teus, M. A [87] | 2019 | Spain | Retrospective | 48 | 27/21 | 72.7 ± 12.51 | XEN | 48 m | |
Barão, R.C [18] | 2020 | Portugal | Retrospective | 42 | 12/30 | 71.7 ± 12 | XEN; phaco-XEN | 18 m | |
Başer, E. F [19] | 2020 | Turkey | Retrospective | 29 | 17/12 | 67.5 ± 10.3 | XEN | 24 m | |
Bravetti, G.E [20] | 2020 | Switzerland | Retrospective | 60 | 32/28 | 64.7 ± 23.1 | XEN | 12 m | |
Buffault, J [21] | 2020 | France | Retrospective | 107 | 58/49 | 68.3 ± 10.8 | XEN; phaco-XEN | 6 m | |
Busch, T [22] | 2020 | Sweden | Retrospective | 113 | 53/50 | 70.8 ± 11.8 | XEN | 12 m | |
Cutolo, CA [24] | 2020 | Italy | Prospective | 123 | 58/65 | 74.5 (67.1–81.3) | XEN | 12 m | 1 |
Dar, N [25] | 2020 | Israel | Retrospective | 46 | 22/24 | 74 ± 9.4 | XEN | 6 m | |
Do, A [27] | 2020 | US | Retrospective | 137 | 76/61 | 72 ± 13.2 | XEN | 12 m | |
Fea, A. M [28] | 2020 | Italy | Prospective | 298 | 149/149 | 70.3 ± 11.8 | XEN; phaco-XEN | 12 m | 1 |
Fernández-García, A [30] | 2020 | Spain | Retrospective | 40 | 17/23 | 77.31 ± 6.33 | XEN | 36 m | |
Fernández-García, A [31] | 2020 | Spain | Retrospective | 93 | 22/41 | 74 ± 8 | XEN | 36 m | |
Gabbay, I. E [32] | 2020 | UK | Retrospective | 151 | 82/69 | 74.3 ± 11.0 | XEN; phaco-XEN | 24 m | |
Gillmann, K [35] | 2020 | Switzerland | Prospective | 92 | 23/45 | 76.3 ± 9.1 | XEN; phaco-XEN | 36 m | 1 |
Gillmann, K [36] | 2020 | Switzerland | Prospective | 37 | 10/27 | 77.7 ± 9.1 | XEN | 24 m | 1 |
Hong, K [43] | 2020 | US | Prospective | 28 | 11/17 | 66.6 ± 11 | XEN | 12 m | 0 |
Hu, J. Y [44] | 2020 | Singapore | Retrospective | 63 | 50/13 | 71.9 ± 7.1 | XEN; phaco-XEN | 6 m | |
Ibáñez-Muñoz, A [46] | 2020 | Spain | Retrospective | 73 | 39/34 | 79.7 ± 8.2 | XEN; phaco-XEN | 12 m | |
Laborda-Guirao, T [51] | 2020 | Spain | Retrospective | 80 | 42/38 | 74.0 + 10.4 | XEN; phaco-XEN | 12 m | |
Lavin-Dapena, C [53] | 2020 | Spain | Prospective | 11 | 2/9 | 78.8 | XEN; phaco-XEN | 18 m | 0 |
Linton, E [57] | 2020 | UK | Retrospective | 151 | 38/113 | 71 ± 12.6 | XEN | 12 m | |
Midha, N [63] | 2020 | Switzerland | Prospective | 51 | 15/36 | 74.4 ± 9.4 | XEN; phaco-XEN | 24 m | 0 |
Olgun, A [67] | 2020 | Turkey | Retrospective | 221 | 42/72 | 65.8 ± 10.6 | XEN; phaco-XEN; TB | 24 m | |
Olgun, A [68] | 2020 | Turkey | Retrospective | 80 | 29/35 | 61.1 ± 12.1 | XEN; TB | 3 m | |
Post, M [71] | 2020 | Poland | Prospective | 20 | 6/11 | 69.85 ± 4.69 | XEN | 12 m | 1 |
Rather, P.A. [73] | 2020 | US | Retrospective | 92 | 31/35 | 75.3 | XEN; phaco-XEN | 12 m | |
Rauchegger, T [74] | 2020 | Austria | Retrospective | 79 | 49/30 | - | XEN; phaco-XEN | 24 m | |
Schargus, M [77] | 2020 | Germany | Retrospective | 113 | 73/80 | 70.2 ± 10.8 | XEN | 12 m | |
Scheres, M. J [78] | 2020 | Netherlands | Retrospective | 82 | 41/41 | 69 ± 8 | XEN | 24 m | |
Sharpe, R [80] | 2020 | US | Retrospective | 179 | 88/91 | 74.5 ± 7.6 | XEN; TB | 6 m | |
Teixeira, F.J [86] | 2020 | Portugal | Prospective | 12 | 6/6 | 59 ± 19 | XEN | 12 m | 1 |
Theillac, V [88] | 2020 | France | Retrospective | 105 | 47/58 | 72.1 ± 8.7 | XEN | 6 m | |
Wałek, E [90] | 2020 | Poland | Prospective | 39 | 19/20 | 67 | XEN; phaco-XEN | 24 m | 1 |
Widder, R. A [92] | 2020 | Germany | Retrospective | 90 | - | 72 ± 13 | XEN | 48 m | |
Chao, Y.J [23] | 2021 | China | Retrospective | 37 | 24/14 | 53.4 ± 13.6 | XEN | 12 m | |
Oddone, F [65] | 2021 | Italy | Prospective | 108 | 84/84 | 69.1 ± 12.9 | XEN; phaco-XEN | 6 m | 0 |
Reitsamer, H [76] | 2021 | Austria | Retrospective | 212 | 83/94 | 76 ± 7.1 | XEN; phaco-XEN | 36 m | |
Tan, N.E [84] | 2021 | US | Retrospective | 50 | - | 71.0 ± 13.4 | XEN | 12 m | |
Urcola, A [89] | 2021 | Spain | Retrospective | 20 | 3/7 | 76.1 ± 12 | XEN; phaco-XEN | 12 m |