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Fig. 7 | BMC Ophthalmology

Fig. 7

From: Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

Fig. 7

Retinal regeneration model. Inhibition of GABA-A receptors in the zebrafish retina induced muller glial (MG)-dependent regeneration [12, 44]. The Kent et al., 2021 [45] study results further support decreasing GABA levels as a potential mechanism for retinal regeneration via MG de-differentiation and generation of progenitor cells. This regenerative pathway, however, may be inhibited by the hippo pathway in mammals. Inhibition of the hippo pathway may induce potential retinal regenerative capacity by adult human MG [46]. Select steroid metabolites have been demonstrated to inhibit GABA-A activity while others exhibited barbiturate-like activity [15, 16]. GABA-A rho has also been shown to be highly expressed in the retina and was thus surveyed for in this study [47]. Pie charts adjacent to proteins represent the protein’s relative abundance in the periphery (blue), macula (orange), and fovea (gray) based on the mass spectrometry data provided by the Skeie and Mahajan [5] study

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