Fig. 2

Disease progression and outcomes of case 5. A-C Multimodal imaging examinations of case 5 at initial indicating the diagnosis of Vogt-Koyanagi-Harada disease (VKH). A Wide field fundus photography demonstrated multiple exudative retinal detachment (ERD) in the left eye. B Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) revealed typical acute VKH. C OCT presented multilobular ERD and hyperreflective dots, a single PED, and undulating RPE. The PED angle (PEDA) was 82.55°.D OCT, taken 3 weeks after systemic corticosteroid treatment, showed a quiet shallow neurosensory retinal detachment, the thinned inner choroidal layer and dilated large choroidal vessel (red pentagram) beneath the persisted PED in the left eye. The PEDA increased to 89.13°. E–G Development of central serous chorioretinopathy (CSC) during the systemic corticosteroid treatment period. E Fundus photography showed dome-shaped macular (white arrows). F Multiple leakages with “ink-blot’’ pattern was noted on FFA (yellow arrows). G OCT showed sensory retinal detachment corresponding dome-shaped macular, persisted PED, thinned inner choroidal layer and dilated large choroidal vessel (red pentagram). The PEDA increased to 112.17°. H Persisted PED and dilated choroidal large vessels (red pentagrams) were noted on OCT after macular subretinal fluid of CSC resolved completely at the last follow-up. The PEDA of the persisted PED was 104.44