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Cornea and external eye diseases

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. The World Health Organization (WHO) recommends annual mass azithromycin distribution until districts drop below 5% prevalence of trachomatous inflammation—follicular (TF). Districts with very low TF prevalence...

    Authors: Abdou Amza, Boubacar Kadri, Beido Nassirou, Ahmed M. Arzika, Ariana Austin, Fanice Nyatigo, Elodie Lebas, Benjamin F. Arnold, Thomas M. Lietman and Catherine E. Oldenburg

    Citation: BMC Ophthalmology 2021 21:15

    Content type: Study protocol

    Published on:

  2. To assess the prevalence and demographics of lower eyelid epiblepharon in Chinese preschool children and to evaluate its association with refractive errors.

    Authors: Deyi Zhuo, Si Chen, Xiaofang Ren, Bingsong Wang, Linbo Liu and Lin Xiao

    Citation: BMC Ophthalmology 2021 21:3

    Content type: Research article

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  3. To compare the clinical characteristics of dry eye patients with ocular neuropathic pain features according to the types of sensitization based on the Ocular Pain Assessment Survey (OPAS).

    Authors: Jonghwa Kim, Hyeon Jeong Yoon, In Cheon You, Byung Yi Ko and Kyung Chul Yoon

    Citation: BMC Ophthalmology 2020 20:455

    Content type: Research article

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  4. The aim of our study was to assess changes of tear film osmolarity after micro-incision 25G+ pars plana vitrectomy (PPV) in a prospective study.

    Authors: J. Němčanský, A. Kopecký and P. Mašek

    Citation: BMC Ophthalmology 2020 20:452

    Content type: Research article

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  5. Until recently, synthetic fiber conjunctival granuloma (SFCG) is rarely reported and has been poorly understood. Our study was to explore the clinical features, histopathologic characteristics, surgical outcom...

    Authors: Zhang Chen, Tianyang Wang, Qintuo Pan, Zhaoliang Zhang and Zongduan Zhang

    Citation: BMC Ophthalmology 2020 20:448

    Content type: Research article

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  6. To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins.

    Authors: Xiaoyan Zhang, Rongjun Liu, Yiyun Liu, Shuang Zhang and Hong Qi

    Citation: BMC Ophthalmology 2020 20:446

    Content type: Case report

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  7. Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progress...

    Authors: Praveen Raj, Sushma Tejwani, Dandayudhapani Sudha, B. Muthu Narayanan, Chandrasekar Thangapandi, Sankar Das, J. Somasekar, Susmithasane Mangalapudi, Durgesh Kumar, Narendra Pindipappanahalli, Rohit Shetty, Arkasubhra Ghosh, Govindasamy Kumaramanickavel, Amitabha Chaudhuri and Nagasamy Soumittra

    Citation: BMC Ophthalmology 2020 20:442

    Content type: Research article

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  8. The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, bli...

    Authors: Hyung Bin Hwang, Yong Ho Ku, Eun Chul Kim, Hyun Seung Kim, Man Soo Kim and Ho Sik Hwang

    Citation: BMC Ophthalmology 2020 20:438

    Content type: Research article

    Published on:

  9. Hurler syndrome-associated keratopathy is an exceedingly rare corneal disorder that requires corneal transplantation in advanced stages. Precise assessment of the corneal condition is necessary for deciding wh...

    Authors: Elodie Da Cunha, Cristina Georgeon, Nacim Bouheraoua, Marc Putterman, Françoise Brignole-Baudouin and Vincent M. Borderie

    Citation: BMC Ophthalmology 2020 20:433

    Content type: Case report

    Published on:

  10. Paclitaxel (PTX) is an antineoplastic drug widely used in treatments for ovarian, breast, and small-cell lung cancer. Although ocular effects associated with PTX have been previously described, very few studie...

    Authors: Amardeep Sekhon, Jeff Y. F. Wang, Johnson C. H. Tan, Simon P. Holland and Sonia N. Yeung

    Citation: BMC Ophthalmology 2020 20:400

    Content type: Case report

    Published on:

  11. To evaluate the correlations between lipid layer thickness (LLT) and morphology and function of the meibomian glands in patients who were diagnosed as meibomian gland dysfunction (MGD) in different age groups.

    Authors: Junhua Li, Jiling Ma, Man Hu, Jianqin Yu and Yune Zhao

    Citation: BMC Ophthalmology 2020 20:394

    Content type: Research article

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  12. The lacrimal ductal cyst (dacryops) is an uncommon clinical entity. It occurs anywhere that lacrimal gland tissue is present but most often appears as an expanding mass in the region of the lacrimal gland. The...

    Authors: Yu Zhang, Changhong Zeng, Ningshao Chen and Chunling Liu

    Citation: BMC Ophthalmology 2020 20:380

    Content type: Case report

    Published on:

  13. Mycobacterium haemophilum is a rare and emerging nontuberculous mycobacteria (NTM). It normally causes localized or disseminated systemic diseases, particularly skin infections and arthritis in severely immunocom...

    Authors: Punyanuch Pisitpayat, Tasanee Sirikul, Poonpilas Hongmanee, Pitak Santanirand and Kaevalin Lekhanont

    Citation: BMC Ophthalmology 2020 20:378

    Content type: Case report

    Published on:

  14. The aim of this study was to evaluate the clinical outcomes of pars plana vitrectomy (PPV) combined with penetrating keratoplasty (PKP) and transscleral-sutured intraocular lens (IOL) implantation (IOL-suture)...

    Authors: Takahiko Hayashi, Ida Yasutsugu, Toshiki Shimizu, Tsubasa Kuroki, Yuji Kobashigawa, Yasuhito Iijima and Kentaro Yuda

    Citation: BMC Ophthalmology 2020 20:369

    Content type: Research article

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  15. Herpes simplex virus type 1 (HSV-1) keratitis is a major cause of corneal blindness in the world, and an in-depth understanding of its pathogenesis may help improve existing diagnosis and treatment. The purpos...

    Authors: Hua Yang, Xiaozhao Yang, Yani Wang, Xuan Zheng, Yi Zhang and Yan Shao

    Citation: BMC Ophthalmology 2020 20:355

    Content type: Research article

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  16. Neuromuscular hamartoma is a very rare tumor; with only five cases reported in the orbit. It often occurs in infants and young children and involves large peripheral nerves, but there has been only few reports...

    Authors: Tae-Sung Joo, Hyejee Kim, In-Ki Park and Jae-Ho Shin

    Citation: BMC Ophthalmology 2020 20:334

    Content type: Case report

    Published on:

  17. The sparsity of established tools for the grading of limbal stem cell deficiency hinder objective assessments of the clinical outcome of cultivated limbal epithelial cell transplantation. To advance towards th...

    Authors: Ozlem Barut Selver, Mehmet Gurdal, Ayse Yagci, Sait Egrilmez, Melis Palamar, Turker Cavusoglu, Ali Veral, Cagri Guven, Utku Ates, Zheng Wang and J. Mario Wolosin

    Citation: BMC Ophthalmology 2020 20:325

    Content type: Research article

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  18. Visual impairment refers to presenting distance visual acuity worse than 6/18 in the worst eye. It remains a global challenge that greatly affects the mobility, social participation and the quality of life of ...

    Authors: Natnael Lakachew Assefa, Addisu Wondifraw Admas and Nebiyat Feleke Adimasu

    Citation: BMC Ophthalmology 2020 20:316

    Content type: Research article

    Published on:

  19. To evaluate the effects of topical citicoline and vitamin B12 (Cit-B12: OMK2, Omikron Italia srl, Italy) on corneal innervation of patients with diabetic neuropathy.

    Authors: Paolo Fogagnolo, Ettore Melardi, Laura Tranchina and Luca Rossetti

    Citation: BMC Ophthalmology 2020 20:315

    Content type: Research article

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  20. The endothelial rejection line is rarely seen after Descemet stripping automated endothelial keratoplasties (DSAEKs). Here, we present a case of endothelial graft rejection with an endothelial rejection line o...

    Authors: Muhannad Alkhalifah, Bader Alqahtani, Abdulmohsen Almulhim and Waleed Alsarhani

    Citation: BMC Ophthalmology 2020 20:307

    Content type: Case report

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  21. To determine the average amount of mechanical forces applied to the lids of keratoconus patients during eye rubbing.

    Authors: Farhad Hafezi, Nikki L. Hafezi, Bojan Pajic, Francesca Gilardoni, J. Bradley Randleman, Jose Alvaro P. Gomes, Léonard Kollros, Mark Hillen and Emilio A. Torres-Netto

    Citation: BMC Ophthalmology 2020 20:301

    Content type: Research article

    Published on:

  22. Explanted corneae are highly needed for the surgical management of patients with severe corneal diseases. The aim of this study was to determine whether the body donors from the Institute of Anatomy are a suit...

    Authors: Cristina Martin, Thomas Tschernig, Hamon Loic, Loay Daas and Berthold Seitz

    Citation: BMC Ophthalmology 2020 20:284

    Content type: Research article

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  23. The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This s...

    Authors: Gracia Castro-Luna and Antonio Pérez-Rueda

    Citation: BMC Ophthalmology 2020 20:263

    Content type: Research article

    Published on:

  24. The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens...

    Authors: Jiaqi Zhou, Feng Xue, Xingtao Zhou, Rajeev Krishnan Naidu and Yishan Qian

    Citation: BMC Ophthalmology 2020 20:240

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Ophthalmology 2020 20:338

  25. To report a case of enucleation caused by Streptococcus dysgalactiae endophthalmitis after traumatic corneal laceration.

    Authors: Yong Woo Lee, Kyung Min Koh, Kyu Yeon Hwang, Young A. Kwon, Dong Won Lee, Sang Wroul Song, Byoung Yeop Kim and Kook Young Kim

    Citation: BMC Ophthalmology 2020 20:238

    Content type: Case report

    Published on:

  26. Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK)....

    Authors: Clemence Bonnet, Louis Debillon, Saba Al-Hashimi, Florence Hoogewoud, Dominique Monnet, Jean-Louis Bourges and Antoine Brézin

    Citation: BMC Ophthalmology 2020 20:205

    Content type: Research article

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  27. Healthy corneal epithelium acts as a barrier against damage to the deeper structures in the eye. Failure in the mechanisms of corneal epithelization can lead to persistent epithelial defects of the cornea (PED...

    Authors: Hyun Sik Moon, Lan Li, Hyeon Jeong Yoon, Yong Sok Ji and Kyung Chul Yoon

    Citation: BMC Ophthalmology 2020 20:147

    Content type: Research article

    Published on:

  28. Several previous studies reported a greater prevalence of dry eye syndrome (DES) among patients with psychiatric diseases. The aim of this study is to investigate the prevalence and risk factors of DES in pati...

    Authors: Chiao-Ying Liang, Wai-Man Cheang, Chun-Yuan Wang, Keng-Hung Lin, Li-Chen Wei, Yu-Yen Chen and Ying-Cheng Shen

    Citation: BMC Ophthalmology 2020 20:123

    Content type: Research article

    Published on:

  29. The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration....

    Authors: Kimberly M. Brothers, Nicholas A. Stella and Robert M. Q. Shanks

    Citation: BMC Ophthalmology 2020 20:120

    Content type: Research article

    Published on:

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