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Cornea and external eye diseases

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. To evaluate microstructural changes in the meibomian glands (MGs) in patients with active and inactive Graves’ orbitopathy (GO), using in vivo confocal microscopy (IVCM), and to investigate the correlations be...

    Authors: Shengnan Cheng, Yueqi Yu, Jin Chen, Lin Ye, Xinghua Wang and Fagang Jiang

    Citation: BMC Ophthalmology 2021 21:261

    Content type: Research article

    Published on:

  3. Mucopolysaccharidosis type VI (MPS VI) is a rare autosomal recessive inherited disease caused by mutations in the arylsulfatase B (ARSB) gene. MPS VI is a multisystemic disease resulting from a deficiency in aryl...

    Authors: Ming-Fang He, Ji Yang, Meng-Jie Dong, Yin-Ting Wang and Hai Liu

    Citation: BMC Ophthalmology 2021 21:214

    Content type: Case report

    Published on:

  4. The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China.

    Authors: Fangting Li, Qin Zhang, Xin Ying, Jing He, Yuebo Jin, Huiwen Xu, Yaobin Cheng and Mingwei Zhao

    Citation: BMC Ophthalmology 2021 21:211

    Content type: Research article

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  5. Cytomegalovirus (CMV) has been known to cause unilateral corneal endotheliitis with keratic precipitates and localized corneal edema, iridocyclitis, and secondary glaucoma. CMV endotheliitis is diagnosed based...

    Authors: Suguru Nakagawa, Hitoha Ishii, Mitsuko Takamoto, Toshikatsu Kaburaki, Kiyoshi Ishii and Takashi Miyai

    Citation: BMC Ophthalmology 2021 21:194

    Content type: Case report

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  6. Remnant interface fluid following Descemet stripping automated endothelial keratoplasty (DSAEK) is associated with postoperative detachments. The aim of this study was to assess outcomes of intraoperative opti...

    Authors: Michael Mimouni, Martin Kronschläger, Manuel Ruiss and Oliver Findl

    Citation: BMC Ophthalmology 2021 21:180

    Content type: Research article

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  7. To evaluate the effects of lid debris debridement and meibomian gland expression (MGX) on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe MGD.

    Authors: Su Young Moon, Sol Ah Han, Hye Ji Kwon, So Young Park, Jae Hyuck Lee, Ho Seok Chung, Jae Yong Kim, Hungwon Tchah and Hun Lee

    Citation: BMC Ophthalmology 2021 21:175

    Content type: Research article

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  8. Chronic ocular graft-versus-host disease (oGVHD) is an ocular comorbidity of graft-versus-host disease (GVHD) that usually occurs concurrently with systemic manifestations. Failure to detect and treat oGVHD in...

    Authors: Hideto Ikarashi, Naohiko Aketa, Eisuke Shimizu, Yoji Takano, Tetsuya Kawakita, Yuichi Uchino, Yukihiro Matsumoto, Junko Ogawa, Kazuo Tsubota and Yoko Ogawa

    Citation: BMC Ophthalmology 2021 21:164

    Content type: Case report

    Published on:

  10. Conjunctival autograft transplantation from superior conjunctiva is often chosen to lower the postoperative recurrence rate for pterygium treatment. However, inferior conjunctival autograft (ICA) might be take...

    Authors: Wenwei Li, Yaoyong Lou and Bin Wang

    Citation: BMC Ophthalmology 2021 21:131

    Content type: Research article

    Published on:

  13. The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary ...

    Authors: Ji Eun Kim, Na Rae Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-im Kim and Ji Won Jung

    Citation: BMC Ophthalmology 2021 21:114

    Content type: Research article

    Published on:

  15. To compare ocular and corneal inherent aberrations in the naked eyes of randomly selected children fitted with MiSight contact lenses (CL) for myopia control, versus children corrected with single-vision spect...

    Authors: Daniela Lopes-Ferreira, Alicia Ruiz-Pomeda, Belén Peréz-Sanchéz, António Queirós and César Villa-Collar

    Citation: BMC Ophthalmology 2021 21:112

    Content type: Research article

    Published on:

  19. The World Health Organization (WHO) recommends annual mass azithromycin distribution until districts drop below 5% prevalence of trachomatous inflammation—follicular (TF). Districts with very low TF prevalence...

    Authors: Abdou Amza, Boubacar Kadri, Beido Nassirou, Ahmed M. Arzika, Ariana Austin, Fanice Nyatigo, Elodie Lebas, Benjamin F. Arnold, Thomas M. Lietman and Catherine E. Oldenburg

    Citation: BMC Ophthalmology 2021 21:15

    Content type: Study protocol

    Published on:

  21. To assess the prevalence and demographics of lower eyelid epiblepharon in Chinese preschool children and to evaluate its association with refractive errors.

    Authors: Deyi Zhuo, Si Chen, Xiaofang Ren, Bingsong Wang, Linbo Liu and Lin Xiao

    Citation: BMC Ophthalmology 2021 21:3

    Content type: Research article

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  25. To compare the clinical characteristics of dry eye patients with ocular neuropathic pain features according to the types of sensitization based on the Ocular Pain Assessment Survey (OPAS).

    Authors: Jonghwa Kim, Hyeon Jeong Yoon, In Cheon You, Byung Yi Ko and Kyung Chul Yoon

    Citation: BMC Ophthalmology 2020 20:455

    Content type: Research article

    Published on:

  26. The aim of our study was to assess changes of tear film osmolarity after micro-incision 25G+ pars plana vitrectomy (PPV) in a prospective study.

    Authors: J. Němčanský, A. Kopecký and P. Mašek

    Citation: BMC Ophthalmology 2020 20:452

    Content type: Research article

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  28. Until recently, synthetic fiber conjunctival granuloma (SFCG) is rarely reported and has been poorly understood. Our study was to explore the clinical features, histopathologic characteristics, surgical outcom...

    Authors: Zhang Chen, Tianyang Wang, Qintuo Pan, Zhaoliang Zhang and Zongduan Zhang

    Citation: BMC Ophthalmology 2020 20:448

    Content type: Research article

    Published on:

  29. To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins.

    Authors: Xiaoyan Zhang, Rongjun Liu, Yiyun Liu, Shuang Zhang and Hong Qi

    Citation: BMC Ophthalmology 2020 20:446

    Content type: Case report

    Published on:

  30. Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progress...

    Authors: Praveen Raj, Sushma Tejwani, Dandayudhapani Sudha, B. Muthu Narayanan, Chandrasekar Thangapandi, Sankar Das, J. Somasekar, Susmithasane Mangalapudi, Durgesh Kumar, Narendra Pindipappanahalli, Rohit Shetty, Arkasubhra Ghosh, Govindasamy Kumaramanickavel, Amitabha Chaudhuri and Nagasamy Soumittra

    Citation: BMC Ophthalmology 2020 20:442

    Content type: Research article

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  31. The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, bli...

    Authors: Hyung Bin Hwang, Yong Ho Ku, Eun Chul Kim, Hyun Seung Kim, Man Soo Kim and Ho Sik Hwang

    Citation: BMC Ophthalmology 2020 20:438

    Content type: Research article

    Published on:

  33. Hurler syndrome-associated keratopathy is an exceedingly rare corneal disorder that requires corneal transplantation in advanced stages. Precise assessment of the corneal condition is necessary for deciding wh...

    Authors: Elodie Da Cunha, Cristina Georgeon, Nacim Bouheraoua, Marc Putterman, Françoise Brignole-Baudouin and Vincent M. Borderie

    Citation: BMC Ophthalmology 2020 20:433

    Content type: Case report

    Published on:

  34. Paclitaxel (PTX) is an antineoplastic drug widely used in treatments for ovarian, breast, and small-cell lung cancer. Although ocular effects associated with PTX have been previously described, very few studie...

    Authors: Amardeep Sekhon, Jeff Y. F. Wang, Johnson C. H. Tan, Simon P. Holland and Sonia N. Yeung

    Citation: BMC Ophthalmology 2020 20:400

    Content type: Case report

    Published on:

  35. To evaluate the correlations between lipid layer thickness (LLT) and morphology and function of the meibomian glands in patients who were diagnosed as meibomian gland dysfunction (MGD) in different age groups.

    Authors: Junhua Li, Jiling Ma, Man Hu, Jianqin Yu and Yune Zhao

    Citation: BMC Ophthalmology 2020 20:394

    Content type: Research article

    Published on:

  36. The lacrimal ductal cyst (dacryops) is an uncommon clinical entity. It occurs anywhere that lacrimal gland tissue is present but most often appears as an expanding mass in the region of the lacrimal gland. The...

    Authors: Yu Zhang, Changhong Zeng, Ningshao Chen and Chunling Liu

    Citation: BMC Ophthalmology 2020 20:380

    Content type: Case report

    Published on:

  37. Mycobacterium haemophilum is a rare and emerging nontuberculous mycobacteria (NTM). It normally causes localized or disseminated systemic diseases, particularly skin infections and arthritis in severely immunocom...

    Authors: Punyanuch Pisitpayat, Tasanee Sirikul, Poonpilas Hongmanee, Pitak Santanirand and Kaevalin Lekhanont

    Citation: BMC Ophthalmology 2020 20:378

    Content type: Case report

    Published on:

  38. The aim of this study was to evaluate the clinical outcomes of pars plana vitrectomy (PPV) combined with penetrating keratoplasty (PKP) and transscleral-sutured intraocular lens (IOL) implantation (IOL-suture)...

    Authors: Takahiko Hayashi, Ida Yasutsugu, Toshiki Shimizu, Tsubasa Kuroki, Yuji Kobashigawa, Yasuhito Iijima and Kentaro Yuda

    Citation: BMC Ophthalmology 2020 20:369

    Content type: Research article

    Published on:

  40. Herpes simplex virus type 1 (HSV-1) keratitis is a major cause of corneal blindness in the world, and an in-depth understanding of its pathogenesis may help improve existing diagnosis and treatment. The purpos...

    Authors: Hua Yang, Xiaozhao Yang, Yani Wang, Xuan Zheng, Yi Zhang and Yan Shao

    Citation: BMC Ophthalmology 2020 20:355

    Content type: Research article

    Published on:

  41. Neuromuscular hamartoma is a very rare tumor; with only five cases reported in the orbit. It often occurs in infants and young children and involves large peripheral nerves, but there has been only few reports...

    Authors: Tae-Sung Joo, Hyejee Kim, In-Ki Park and Jae-Ho Shin

    Citation: BMC Ophthalmology 2020 20:334

    Content type: Case report

    Published on:

  42. The sparsity of established tools for the grading of limbal stem cell deficiency hinder objective assessments of the clinical outcome of cultivated limbal epithelial cell transplantation. To advance towards th...

    Authors: Ozlem Barut Selver, Mehmet Gurdal, Ayse Yagci, Sait Egrilmez, Melis Palamar, Turker Cavusoglu, Ali Veral, Cagri Guven, Utku Ates, Zheng Wang and J. Mario Wolosin

    Citation: BMC Ophthalmology 2020 20:325

    Content type: Research article

    Published on:

  44. Visual impairment refers to presenting distance visual acuity worse than 6/18 in the worst eye. It remains a global challenge that greatly affects the mobility, social participation and the quality of life of ...

    Authors: Natnael Lakachew Assefa, Addisu Wondifraw Admas and Nebiyat Feleke Adimasu

    Citation: BMC Ophthalmology 2020 20:316

    Content type: Research article

    Published on:

  45. To evaluate the effects of topical citicoline and vitamin B12 (Cit-B12: OMK2, Omikron Italia srl, Italy) on corneal innervation of patients with diabetic neuropathy.

    Authors: Paolo Fogagnolo, Ettore Melardi, Laura Tranchina and Luca Rossetti

    Citation: BMC Ophthalmology 2020 20:315

    Content type: Research article

    Published on:

  46. The endothelial rejection line is rarely seen after Descemet stripping automated endothelial keratoplasties (DSAEKs). Here, we present a case of endothelial graft rejection with an endothelial rejection line o...

    Authors: Muhannad Alkhalifah, Bader Alqahtani, Abdulmohsen Almulhim and Waleed Alsarhani

    Citation: BMC Ophthalmology 2020 20:307

    Content type: Case report

    Published on:

  47. To determine the average amount of mechanical forces applied to the lids of keratoconus patients during eye rubbing.

    Authors: Farhad Hafezi, Nikki L. Hafezi, Bojan Pajic, Francesca Gilardoni, J. Bradley Randleman, Jose Alvaro P. Gomes, Léonard Kollros, Mark Hillen and Emilio A. Torres-Netto

    Citation: BMC Ophthalmology 2020 20:301

    Content type: Research article

    Published on:

  48. Explanted corneae are highly needed for the surgical management of patients with severe corneal diseases. The aim of this study was to determine whether the body donors from the Institute of Anatomy are a suit...

    Authors: Cristina Martin, Thomas Tschernig, Hamon Loic, Loay Daas and Berthold Seitz

    Citation: BMC Ophthalmology 2020 20:284

    Content type: Research article

    Published on:

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