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Cornea and external eye diseases

Section edited by Penny Asbell

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. Content type: Research article

    This study is aim to compare the clinical effectiveness between the two most prominent dry eye disease (DED)-specific eye drops, 0.05% cyclosporine (CN) and 3% diquafosol (DQ).

    Authors: Chang Hyun Park, Hyung Keun Lee, Mee Kum Kim, Eun Chul Kim, Jae Yong Kim, Tae-im Kim, Hong Kyun Kim, Jong Suk Song, Kyung Chul Yoon, Do Hyung Lee, Tae-Young Chung, Chul Young Choi and Hyun Seung Kim

    Citation: BMC Ophthalmology 2019 19:131

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  2. Content type: Research article

    The purpose of this case series was to further characterize proteasome inhibitor associated chalazia and blepharitis, to investigate outcomes of different management strategies, and to propose a treatment algo...

    Authors: Bonnie A. Sklar, Kalla A. Gervasio, Siyang Leng, Arnab Ghosh, Ajai Chari and Albert Y. Wu

    Citation: BMC Ophthalmology 2019 19:110

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  3. Content type: Technical advance

    To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.

    Authors: Guozhen Niu, Qi Zhou, Xinyu Huang, Sangsang Wang, Juan Zhang, Yushan Zhang and Yanlong Bi

    Citation: BMC Ophthalmology 2019 19:85

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  4. Content type: Research article

    To investigate the efficacy and safety of the retention ring-assisted continuous application of 0.1% riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus.

    Authors: Chung Young Kim and Mee Kum Kim

    Citation: BMC Ophthalmology 2019 19:72

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  5. Content type: Research article

    To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands.

    Authors: Hirotaka Tanabe, Motoko Kawashima, Minako Kaido, Reiko Ishida, Tetsuya Kawakita and Kazuo Tsubota

    Citation: BMC Ophthalmology 2019 19:41

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  6. Content type: Research article

    Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21.6% have low vision. Therefore, this paper aimed to identi...

    Authors: Ipsita Sutradhar, Priyanka Gayen, Mehedi Hasan, Rajat Das Gupta, Tapash Roy and Malabika Sarker

    Citation: BMC Ophthalmology 2019 19:38

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  7. Content type: Research article

    Dry eye disease (DED) is a prevalent complication of diabetes and presents as reduced tear production and/or increased corneal surface sensitivity often with secondary ocular surface changes. This study examin...

    Authors: Patricia J. McLaughlin, Joseph W. Sassani, Michelle B. Titunick and Ian S. Zagon

    Citation: BMC Ophthalmology 2019 19:35

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  8. Content type: Research article

    A recent meta-analysis revealed PAX6 as a risk gene for myopia. There is a link between PAX6 and HOXA9. Furthermore, HOXA9 has been reported to activate TGF-β that is a risk factor for myopia. We speculate HOXA9 ...

    Authors: Chung-Ling Liang, Po-Yuan Hsu, Cheryl S. Ngo, Wei Jie Seow, Neerja Karnani, Hong Pan, Seang-Mei Saw and Suh-Hang H. Juo

    Citation: BMC Ophthalmology 2019 19:28

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  9. Content type: Research article

    To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

    Authors: Qin Xiang, Xu Gao, Jing Fang, Lianhong Pi, Xinke Chen, Lin Chen and Qing Liu

    Citation: BMC Ophthalmology 2019 19:22

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  10. Content type: Research article

    To investigate the effect of scleral buckling (SB) on the morphology and density of human corneal endothelial cells (HCEC).

    Authors: Chia-Yi Lee, Hung-Ta Chen, Hung-Yu Lin, Hung-Chi Chen, Ling Yeung, Yih-Shiou Hwang, Kuan-Jen Chen, Wei-Chi Wu and Chi-Chun Lai

    Citation: BMC Ophthalmology 2019 19:3

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  11. Content type: Research article

    Conventional corneal cross-linking is effective for retarding the progression of keratoconus. However the long-term efficacy and safety of accelerated (45 mW/cm2) transepithelial corneal cross-linking (ATE-CXL...

    Authors: Jinrong Huang, Yang Shen, Weijun Jian, Haipeng Xu, Meiyan Li, Jing Zhao, Xingtao Zhou and Hongfei Liao

    Citation: BMC Ophthalmology 2018 18:337

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  12. Content type: Research article

    Cornea protects the eye against natural and anthropogenic ultraviolet (UV) damage and mechanical injury. Corneal incisions produced by UV lasers in ophthalmic surgeries are often complicated by oxidative stres...

    Authors: Evgeni Yu. Zernii, Olga S. Gancharova, Veronika V. Tiulina, Andrey A. Zamyatnin Jr, Pavel P. Philippov, Viktoriia E. Baksheeva and Ivan I. Senin

    Citation: BMC Ophthalmology 2018 18:336

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  13. Content type: Case report

    External ophtalmomyiasis (EOM) is a zoonosis related to the presence of Oestrus ovis larvae at the ocular level in small ruminants (i.e. ovine, caprine). In humans, EOM is a rare cosmopolitan disorder, mostly des...

    Authors: Louise Basmaciyan, Pierre-Henry Gabrielle, Stéphane Valot, Marc Sautour, Jean-Christophe Buisson, Catherine Creuzot-Garcher and Frédéric Dalle

    Citation: BMC Ophthalmology 2018 18:335

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  14. Content type: Research article

    Pterygium is a condition characterized by epithelial overgrowth of the cornea, inflammatory cell infiltration and an abnormal extracellular matrix accumulation. Chronic UV exposure is considered as a pathogeni...

    Authors: Alexios J. Aletras, Ioannis Trilivas, Maria-Elpida Christopoulou, Sotiria Drakouli, Constantine D. Georgakopoulos and Nikolaos Pharmakakis

    Citation: BMC Ophthalmology 2018 18:328

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  15. Content type: Research article

    Ingrowth of newly formed blood and lymph vessels (angiogenesis) from the limbus region into the cornea can be treated successfully by subconjunctival application of antiangiogenic agents. Currently, there are ...

    Authors: Patrick R. Merz, Nina Röckel, Seda Ballikaya, Gerd U. Auffarth and Ingo Schmack

    Citation: BMC Ophthalmology 2018 18:316

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  16. Content type: Research article

    The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients wit...

    Authors: Olivia L. Lee, Tudor C. Tepelus, Jianyan Huang, Anne G. Irvine, Christopher Irvine, Gloria B. Chiu and SriniVas R. Sadda

    Citation: BMC Ophthalmology 2018 18:309

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  17. Content type: Research article

    To investigate corneal higher-order aberrations (HOAs) of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE) in high myopic and mild to moderate myopic ...

    Authors: Hong-Ying Jin, Ting Wan, Xiao-Ning Yu, Fang Wu and Ke Yao

    Citation: BMC Ophthalmology 2018 18:295

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  18. Content type: Research article

    To investigate thickness changes in the corneal epithelium and Bowman’s layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT).

    Authors: Fan Lu, Aizhu Tao, Weiwei Tao, Xiran Zhuang and Meixiao Shen

    Citation: BMC Ophthalmology 2018 18:286

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  19. Content type: Research article

    A major obstacle that academic institutions face is the steep learning curve for cornea fellows initially learning to perform Descemet Stripping Endothelial Keratoplasty (DSEK). The purpose of this study is to...

    Authors: Jacquelyn Daubert, Terrence P. O’Brien, Eldad Adler and Oriel Spierer

    Citation: BMC Ophthalmology 2018 18:281

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  20. Content type: Research article

    International Task Force (ITF) guidelines established a grading scheme to support treatment of dry eye disease based on clinical signs and symptoms. The purpose of this study was to assess the impact of dry ey...

    Authors: Laurie Barber, Omid Khodai, Thomas Croley, Christopher Lievens, Stephen Montaquila, Jillian Ziemanski, Melissa McCart, Orsolya Lunacsek, Caroline Burk and Vaishali Patel

    Citation: BMC Ophthalmology 2018 18:260

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  21. Content type: Case report

    Descemet’s membrane detachment (DMD) is a rare complication after ocular chemical injury and its pathogenesis remains unclear. In this study, we reported two cases of DMD with traction demonstrated on Anterior...

    Authors: Xiaoling Zhang, Vishal Jhanji and Haoyu Chen

    Citation: BMC Ophthalmology 2018 18:256

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  22. Content type: Research article

    The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands.

    Authors: Cerys J. Evans, Lubica Dudakova, Pavlina Skalicka, Gabriela Mahelkova, Ales Horinek, Alison J. Hardcastle, Stephen J. Tuft and Petra Liskova

    Citation: BMC Ophthalmology 2018 18:250

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  23. Content type: Research article

    To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex®) injection in patients with macular edema secondary to retinal vein occlusion (RVO).

    Authors: Hatice Ayhan Güler, Nurgül Örnek, Kemal Örnek, Nesrin Büyüktortop Gökçınar, Tevfik Oğurel, Mehmet Erhan Yumuşak and Zafer Onaran

    Citation: BMC Ophthalmology 2018 18:235

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  24. Content type: Research article

    Low vision and blindness are major public health problems. A vast burden of worlds visually impaired live in low-income settings especially in sub Saharan Africa. In such settings the blindness is associated w...

    Authors: Fashe Markos Cherinet, Sophia Yoseph Tekalign, Dereje Hayilu Anbesse and Zewdu Yenegeta Bizuneh

    Citation: BMC Ophthalmology 2018 18:232

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  25. Content type: Research article

    To compare clinical characteristics and antibiotic susceptibilities in patients with Pseudomonas aeruginosa (PA) and P. putida (PP) keratitis at a tertiary referral center in South Korea.

    Authors: Chan Ho Cho and Sang-Bumm Lee

    Citation: BMC Ophthalmology 2018 18:204

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  26. Content type: Research article

    Meibomian Gland Dysfunction (MGD) is a leading cause of evaporative Dry Eye Disease (DED). This makes non-invasive meibography an important procedure in the clinical evaluation of DED patients. Our purpose was...

    Authors: Eugene Appenteng Osae, Reynolds Kwame Ablorddepey, Jens Horstmann, David Ben Kumah and Philipp Steven

    Citation: BMC Ophthalmology 2018 18:201

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  27. Content type: Research article

    Mass drug administration with antibiotics predominantly with azithromycin is one of the four arms of the SAFE strategy. The elimination of ocular chlamydial infection is only achieved as long as the azithromyc...

    Authors: Zelalem Tilahun and Teferi Gedif Fenta

    Citation: BMC Ophthalmology 2018 18:193

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  28. Content type: Research article

    To investigate corneal densitometry values obtained using Scheimpflug tomography in normal and highly myopic (HM) eyes and to assess the differences in densitometry values between them.

    Authors: Jing Dong, Yaqin Zhang, Haining Zhang, Zhijie Jia, Suhua Zhang, Bin Sun, Yongqing Han and Xiaogang Wang

    Citation: BMC Ophthalmology 2018 18:182

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  29. Content type: Case report

    Corneal ectasia after small-incision lenticule extraction (SMILE) is uncommon. To our knowledge, this is the first report of 3-year results of combined phototherapeutic keratectomy (PTK) and corneal collagen c...

    Authors: Qingman Ge, Chuanbo Cui, Jing Wang and Guoying Mu

    Citation: BMC Ophthalmology 2018 18:175

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  30. Content type: Research article

    The prospective observation study aimed to evaluate changes in corneal higher-order aberrations induced by advancement of pterygium using an anterior-segment optical coherence tomography (AS-OCT) and Zernike a...

    Authors: Keiichiro Minami, Tadatoshi Tokunaga, Keiichiro Okamoto, Kazunori Miyata and Tetsuro Oshika

    Citation: BMC Ophthalmology 2018 18:166

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  31. Content type: Research article

    Myopia is the leading cause of preventable blindness in children and young adults. Multiple epidemiological studies have confirmed a high prevalence of myopia in Asian countries. However, fewer longitudinal studi...

    Authors: Min Chen, Aimin Wu, Lina Zhang, Wei Wang, Xinyi Chen, Xiaoning Yu and Kaijun Wang

    Citation: BMC Ophthalmology 2018 18:159

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  32. Content type: Research article

    This paper seeks to evaluate the depth and outcomes of MyoRing implantation using two mechanical dissection procedures including: PocketMaker microkeratome in opposition to the Melles hook method.

    Authors: Shiva Pirhadi, Neda Mohammadi, Seyed Aliasghar Mosavi, Hashem Daryabari, Hossein Aghamollaei and Khosrow Jadidi

    Citation: BMC Ophthalmology 2018 18:137

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  33. Content type: Research article

    In our study we describe a method that optimizes size of excision and autografting for primary pterygia along with the use of intraoperative MMC and fibrin glue. Our objective is to propose a simple, optimized...

    Authors: Ho Sik Hwang, Kyong Jin Cho, Gabriel Rand, Roy S. Chuck and Ji Won Kwon

    Citation: BMC Ophthalmology 2018 18:135

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  34. Content type: Research article

    The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium.

    Authors: Xin Pan, Daguang Zhang, Zhifang Jia, Zhehui Chen and Yuetian Su

    Citation: BMC Ophthalmology 2018 18:119

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  35. Content type: Research article

    This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED.

    Authors: Xinrong Zou, Lina Lu, Yi Xu, Jianfeng Zhu, Jiangnan He, Bo Zhang and Haidong Zou

    Citation: BMC Ophthalmology 2018 18:117

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