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Cornea and external eye diseases

Section edited by Penny Asbell

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. Corneal infections with antibiotic-resistant microorganisms are an increasingly difficult management challenge and chemically or photochemically cross-linking the cornea for therapy presents a unique approach ...

    Authors: Daeryl E. Amponin, Joanna Przybek-Skrzypecka, Mariya Zyablitskaya, Anna Takaoka, Leejee H. Suh, Takayuki Nagasaki, Stephen L. Trokel and David C. Paik

    Citation: BMC Ophthalmology 2020 20:28

    Content type: Research article

    Published on:

  2. Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue and disturbance in vision. DED affects patients’ quality of life and leads...

    Authors: Yousef Shanti, Reham Shehada, May M. Bakkar and Jamal Qaddumi

    Citation: BMC Ophthalmology 2020 20:26

    Content type: Research article

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  3. Radiation therapy (RT) is the treatment of choice in patients with low-grade ocular adenexal mucosa-associated lymphoid tissue lymphoma (OAML) and many of them experience post-RT dry eye with varying severity....

    Authors: Sung Eun Kim, Hee Jung Yang and Suk-Woo Yang

    Citation: BMC Ophthalmology 2020 20:24

    Content type: Research article

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  4. We sought to describe corneal epithelial changes after using epidermal (EGFR) or fibroblast growth factor receptor (FGFR) inhibitors as chemotherapy and to clarify incidence and prognosis.

    Authors: Eunhae Shin, Dong Hui Lim, Jisang Han, Do-Hyun Nam, Keunchil Park, Myung-Ju Ahn, Won Ki Kang, Jeeyun Lee, Jin Seok Ahn, Se-Hoon Lee, Jong-Mu Sun, Hyun Ae Jung and Tae-Young Chung

    Citation: BMC Ophthalmology 2020 20:19

    Content type: Research article

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  7. Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide ...

    Authors: Wenbo Hou, Xuguang Sun, Jun Feng, Yang Zhang and Zhiqun Wang

    Citation: BMC Ophthalmology 2019 19:262

    Content type: Research article

    Published on:

  9. We aimed to investigate the effect of short-term orthokeratology lens or frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia.

    Authors: Shuyi Yuan, Shuxian Zhang, Yanglin Jiang and Lihua Li

    Citation: BMC Ophthalmology 2019 19:242

    Content type: Research article

    Published on:

  10. Repeated surgery excisions could induce obvious irregular astigmatism in patients with recurrent pterygium. Our study is aimed to illustrate the effect of adjunct excimer laser phototherapeutic keratectomy (PT...

    Authors: Di Chen, Xiaowei Liu, Qin Long, Zhonghai Wang and Ying Li

    Citation: BMC Ophthalmology 2019 19:238

    Content type: Research article

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  11. Anterior high-resolution optical coherence tomography (HR-OCT) is a novel non-invasive in vivo imaging modality that can assist in the diagnosis and management of various ophthalmic pathologies. The implementa...

    Authors: Yi-Syun Shen, Joseph L. Hu and Chao-Chien Hu

    Citation: BMC Ophthalmology 2019 19:235

    Content type: Case report

    Published on:

  12. Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cor...

    Authors: Yue Zhou, Yuqing Chen, Suiyue Wang, Fangyuan Qin and Liya Wang

    Citation: BMC Ophthalmology 2019 19:226

    Content type: Research article

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  13. Corneal transplantations are surgeries performed for irreparable corneal diseases and damage. However, there is a gap between the number of potential recipients and the number of donor corneas available. The m...

    Authors: Seth Lartey, Ellen K. Antwi-Adjei, Solomon Agyapong, Abdul-Kabir Mohammed, Derrick N. O. Mensah and Edward S. Genego

    Citation: BMC Ophthalmology 2019 19:224

    Content type: Research article

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  15. To investigate the cytotoxicities of the topical ocular dual-action anti-allergic agents (alcaftadine 0.25%, bepotastine besilate 1.5%, and olopatadine HCL 0.1%) on human corneal epithelial cells (HCECs) and t...

    Authors: Sung Il Kim, Choul Yong Park, Gladys Fordjuor, Jong Heon Lee, Jong Soo Lee and Ji Eun Lee

    Citation: BMC Ophthalmology 2019 19:217

    Content type: Research article

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  16. This study aims to optimize the therapeutic regimen for refractory obstructive meibomian gland dysfunction (o-MGD) patients by combining intraductal meibomian gland probing (MGP) and intense pulsed light (IPL)...

    Authors: Xiaodan Huang, Qiyu Qin, Linping Wang, Jiao Zheng, Lin Lin and Xiuming Jin

    Citation: BMC Ophthalmology 2019 19:211

    Content type: Research article

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  19. To investigate the efficacy and safety of repeated phototherapeutic keratectomies (PTKs) during long-term treatment for corneal dystrophy (CD) in a Chinese pedigree carrying the R124L mutation in TGFBI.

    Authors: Li Zeng, Jing Zhao, Yingjun Chen, Jianmin Shang, Aruma Aruma and Xingtao Zhou

    Citation: BMC Ophthalmology 2019 19:191

    Content type: Research article

    Published on:

  20. To evaluate corneal biomechanical properties by the Ocular Response Analyzer (ORA) in non keratoconic patients underwent penetrating keratoplasty (PK).

    Authors: Mohamed Samy Abd Elaziz, Hoda Mohamed Elsobky, Adel Galal Zaky, Eslam Ahmed Maher Hassan and Mahmoud Tawfik KhalafAllah

    Citation: BMC Ophthalmology 2019 19:172

    Content type: Research article

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  21. Clinical outcome after successful reorientation of an upside-down implanted DMEK (Descemet Membrane Endothelial Keratoplasty) graft 4 weeks after initial transplantation.

    Authors: Siegfried Mariacher, Martina Mariacher, Karl Thomas Boden, Peter Szurman and Kai Januschowski

    Citation: BMC Ophthalmology 2019 19:163

    Content type: Case report

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  23. Welders are at an increased risk of eye disorders as a result of their occupation, leading to enormous vocational and economic consequences. With limited published studies among welders in low resource setting...

    Authors: Immaculate Atukunda, Rebecca Claire Lusobya, Samia Hersi Ali, John Mukisa, Juliet Otiti-Sengeri and C. Ateenyi-Agaba

    Citation: BMC Ophthalmology 2019 19:145

    Content type: Research article

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  24. This study is aim to compare the clinical effectiveness between the two most prominent dry eye disease (DED)-specific eye drops, 0.05% cyclosporine (CN) and 3% diquafosol (DQ).

    Authors: Chang Hyun Park, Hyung Keun Lee, Mee Kum Kim, Eun Chul Kim, Jae Yong Kim, Tae-im Kim, Hong Kyun Kim, Jong Suk Song, Kyung Chul Yoon, Do Hyung Lee, Tae-Young Chung, Chul Young Choi and Hyun Seung Kim

    Citation: BMC Ophthalmology 2019 19:131

    Content type: Research article

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  26. The purpose of this case series was to further characterize proteasome inhibitor associated chalazia and blepharitis, to investigate outcomes of different management strategies, and to propose a treatment algo...

    Authors: Bonnie A. Sklar, Kalla A. Gervasio, Siyang Leng, Arnab Ghosh, Ajai Chari and Albert Y. Wu

    Citation: BMC Ophthalmology 2019 19:110

    Content type: Research article

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  28. To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.

    Authors: Guozhen Niu, Qi Zhou, Xinyu Huang, Sangsang Wang, Juan Zhang, Yushan Zhang and Yanlong Bi

    Citation: BMC Ophthalmology 2019 19:85

    Content type: Technical advance

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  29. To investigate the efficacy and safety of the retention ring-assisted continuous application of 0.1% riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus.

    Authors: Chung Young Kim and Mee Kum Kim

    Citation: BMC Ophthalmology 2019 19:72

    Content type: Research article

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  31. To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands.

    Authors: Hirotaka Tanabe, Motoko Kawashima, Minako Kaido, Reiko Ishida, Tetsuya Kawakita and Kazuo Tsubota

    Citation: BMC Ophthalmology 2019 19:41

    Content type: Research article

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  32. Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21.6% have low vision. Therefore, this paper aimed to identi...

    Authors: Ipsita Sutradhar, Priyanka Gayen, Mehedi Hasan, Rajat Das Gupta, Tapash Roy and Malabika Sarker

    Citation: BMC Ophthalmology 2019 19:38

    Content type: Research article

    Published on:

  33. Dry eye disease (DED) is a prevalent complication of diabetes and presents as reduced tear production and/or increased corneal surface sensitivity often with secondary ocular surface changes. This study examin...

    Authors: Patricia J. McLaughlin, Joseph W. Sassani, Michelle B. Titunick and Ian S. Zagon

    Citation: BMC Ophthalmology 2019 19:35

    Content type: Research article

    Published on:

  34. A recent meta-analysis revealed PAX6 as a risk gene for myopia. There is a link between PAX6 and HOXA9. Furthermore, HOXA9 has been reported to activate TGF-β that is a risk factor for myopia. We speculate HOXA9 ...

    Authors: Chung-Ling Liang, Po-Yuan Hsu, Cheryl S. Ngo, Wei Jie Seow, Neerja Karnani, Hong Pan, Seang-Mei Saw and Suh-Hang H. Juo

    Citation: BMC Ophthalmology 2019 19:28

    Content type: Research article

    Published on:

  35. To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

    Authors: Qin Xiang, Xu Gao, Jing Fang, Lianhong Pi, Xinke Chen, Lin Chen and Qing Liu

    Citation: BMC Ophthalmology 2019 19:22

    Content type: Research article

    Published on:

  37. To investigate the effect of scleral buckling (SB) on the morphology and density of human corneal endothelial cells (HCEC).

    Authors: Chia-Yi Lee, Hung-Ta Chen, Hung-Yu Lin, Hung-Chi Chen, Ling Yeung, Yih-Shiou Hwang, Kuan-Jen Chen, Wei-Chi Wu and Chi-Chun Lai

    Citation: BMC Ophthalmology 2019 19:3

    Content type: Research article

    Published on:

  38. Conventional corneal cross-linking is effective for retarding the progression of keratoconus. However the long-term efficacy and safety of accelerated (45 mW/cm2) transepithelial corneal cross-linking (ATE-CXL...

    Authors: Jinrong Huang, Yang Shen, Weijun Jian, Haipeng Xu, Meiyan Li, Jing Zhao, Xingtao Zhou and Hongfei Liao

    Citation: BMC Ophthalmology 2018 18:337

    Content type: Research article

    Published on:

  39. Cornea protects the eye against natural and anthropogenic ultraviolet (UV) damage and mechanical injury. Corneal incisions produced by UV lasers in ophthalmic surgeries are often complicated by oxidative stres...

    Authors: Evgeni Yu. Zernii, Olga S. Gancharova, Veronika V. Tiulina, Andrey A. Zamyatnin Jr, Pavel P. Philippov, Viktoriia E. Baksheeva and Ivan I. Senin

    Citation: BMC Ophthalmology 2018 18:336

    Content type: Research article

    Published on:

  40. External ophtalmomyiasis (EOM) is a zoonosis related to the presence of Oestrus ovis larvae at the ocular level in small ruminants (i.e. ovine, caprine). In humans, EOM is a rare cosmopolitan disorder, mostly des...

    Authors: Louise Basmaciyan, Pierre-Henry Gabrielle, Stéphane Valot, Marc Sautour, Jean-Christophe Buisson, Catherine Creuzot-Garcher and Frédéric Dalle

    Citation: BMC Ophthalmology 2018 18:335

    Content type: Case report

    Published on:

  41. Pterygium is a condition characterized by epithelial overgrowth of the cornea, inflammatory cell infiltration and an abnormal extracellular matrix accumulation. Chronic UV exposure is considered as a pathogeni...

    Authors: Alexios J. Aletras, Ioannis Trilivas, Maria-Elpida Christopoulou, Sotiria Drakouli, Constantine D. Georgakopoulos and Nikolaos Pharmakakis

    Citation: BMC Ophthalmology 2018 18:328

    Content type: Research article

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  42. Ingrowth of newly formed blood and lymph vessels (angiogenesis) from the limbus region into the cornea can be treated successfully by subconjunctival application of antiangiogenic agents. Currently, there are ...

    Authors: Patrick R. Merz, Nina Röckel, Seda Ballikaya, Gerd U. Auffarth and Ingo Schmack

    Citation: BMC Ophthalmology 2018 18:316

    Content type: Research article

    Published on:

  43. The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients wit...

    Authors: Olivia L. Lee, Tudor C. Tepelus, Jianyan Huang, Anne G. Irvine, Christopher Irvine, Gloria B. Chiu and SriniVas R. Sadda

    Citation: BMC Ophthalmology 2018 18:309

    Content type: Research article

    Published on:

  44. To investigate corneal higher-order aberrations (HOAs) of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE) in high myopic and mild to moderate myopic ...

    Authors: Hong-Ying Jin, Ting Wan, Xiao-Ning Yu, Fang Wu and Ke Yao

    Citation: BMC Ophthalmology 2018 18:295

    Content type: Research article

    Published on:

  46. To investigate thickness changes in the corneal epithelium and Bowman’s layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT).

    Authors: Fan Lu, Aizhu Tao, Weiwei Tao, Xiran Zhuang and Meixiao Shen

    Citation: BMC Ophthalmology 2018 18:286

    Content type: Research article

    Published on:

  47. A major obstacle that academic institutions face is the steep learning curve for cornea fellows initially learning to perform Descemet Stripping Endothelial Keratoplasty (DSEK). The purpose of this study is to...

    Authors: Jacquelyn Daubert, Terrence P. O’Brien, Eldad Adler and Oriel Spierer

    Citation: BMC Ophthalmology 2018 18:281

    Content type: Research article

    Published on:

  49. International Task Force (ITF) guidelines established a grading scheme to support treatment of dry eye disease based on clinical signs and symptoms. The purpose of this study was to assess the impact of dry ey...

    Authors: Laurie Barber, Omid Khodai, Thomas Croley, Christopher Lievens, Stephen Montaquila, Jillian Ziemanski, Melissa McCart, Orsolya Lunacsek, Caroline Burk and Vaishali Patel

    Citation: BMC Ophthalmology 2018 18:260

    Content type: Research article

    Published on:

  50. Descemet’s membrane detachment (DMD) is a rare complication after ocular chemical injury and its pathogenesis remains unclear. In this study, we reported two cases of DMD with traction demonstrated on Anterior...

    Authors: Xiaoling Zhang, Vishal Jhanji and Haoyu Chen

    Citation: BMC Ophthalmology 2018 18:256

    Content type: Case report

    Published on:

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