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Cornea and external eye diseases

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. The aim of this study was to evaluate the clinical outcomes of pars plana vitrectomy (PPV) combined with penetrating keratoplasty (PKP) and transscleral-sutured intraocular lens (IOL) implantation (IOL-suture)...

    Authors: Takahiko Hayashi, Ida Yasutsugu, Toshiki Shimizu, Tsubasa Kuroki, Yuji Kobashigawa, Yasuhito Iijima and Kentaro Yuda

    Citation: BMC Ophthalmology 2020 20:369

    Content type: Research article

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  3. Herpes simplex virus type 1 (HSV-1) keratitis is a major cause of corneal blindness in the world, and an in-depth understanding of its pathogenesis may help improve existing diagnosis and treatment. The purpos...

    Authors: Hua Yang, Xiaozhao Yang, Yani Wang, Xuan Zheng, Yi Zhang and Yan Shao

    Citation: BMC Ophthalmology 2020 20:355

    Content type: Research article

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  4. Neuromuscular hamartoma is a very rare tumor; with only five cases reported in the orbit. It often occurs in infants and young children and involves large peripheral nerves, but there has been only few reports...

    Authors: Tae-Sung Joo, Hyejee Kim, In-Ki Park and Jae-Ho Shin

    Citation: BMC Ophthalmology 2020 20:334

    Content type: Case report

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  5. The sparsity of established tools for the grading of limbal stem cell deficiency hinder objective assessments of the clinical outcome of cultivated limbal epithelial cell transplantation. To advance towards th...

    Authors: Ozlem Barut Selver, Mehmet Gurdal, Ayse Yagci, Sait Egrilmez, Melis Palamar, Turker Cavusoglu, Ali Veral, Cagri Guven, Utku Ates, Zheng Wang and J. Mario Wolosin

    Citation: BMC Ophthalmology 2020 20:325

    Content type: Research article

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  7. Visual impairment refers to presenting distance visual acuity worse than 6/18 in the worst eye. It remains a global challenge that greatly affects the mobility, social participation and the quality of life of ...

    Authors: Natnael Lakachew Assefa, Addisu Wondifraw Admas and Nebiyat Feleke Adimasu

    Citation: BMC Ophthalmology 2020 20:316

    Content type: Research article

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  8. To evaluate the effects of topical citicoline and vitamin B12 (Cit-B12: OMK2, Omikron Italia srl, Italy) on corneal innervation of patients with diabetic neuropathy.

    Authors: Paolo Fogagnolo, Ettore Melardi, Laura Tranchina and Luca Rossetti

    Citation: BMC Ophthalmology 2020 20:315

    Content type: Research article

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  9. The endothelial rejection line is rarely seen after Descemet stripping automated endothelial keratoplasties (DSAEKs). Here, we present a case of endothelial graft rejection with an endothelial rejection line o...

    Authors: Muhannad Alkhalifah, Bader Alqahtani, Abdulmohsen Almulhim and Waleed Alsarhani

    Citation: BMC Ophthalmology 2020 20:307

    Content type: Case report

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  10. To determine the average amount of mechanical forces applied to the lids of keratoconus patients during eye rubbing.

    Authors: Farhad Hafezi, Nikki L. Hafezi, Bojan Pajic, Francesca Gilardoni, J. Bradley Randleman, Jose Alvaro P. Gomes, Léonard Kollros, Mark Hillen and Emilio A. Torres-Netto

    Citation: BMC Ophthalmology 2020 20:301

    Content type: Research article

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  11. Explanted corneae are highly needed for the surgical management of patients with severe corneal diseases. The aim of this study was to determine whether the body donors from the Institute of Anatomy are a suit...

    Authors: Cristina Martin, Thomas Tschernig, Hamon Loic, Loay Daas and Berthold Seitz

    Citation: BMC Ophthalmology 2020 20:284

    Content type: Research article

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  15. The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This s...

    Authors: Gracia Castro-Luna and Antonio Pérez-Rueda

    Citation: BMC Ophthalmology 2020 20:263

    Content type: Research article

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  17. The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens...

    Authors: Jiaqi Zhou, Feng Xue, Xingtao Zhou, Rajeev Krishnan Naidu and Yishan Qian

    Citation: BMC Ophthalmology 2020 20:240

    Content type: Research article

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    The Correction to this article has been published in BMC Ophthalmology 2020 20:338

  18. To report a case of enucleation caused by Streptococcus dysgalactiae endophthalmitis after traumatic corneal laceration.

    Authors: Yong Woo Lee, Kyung Min Koh, Kyu Yeon Hwang, Young A. Kwon, Dong Won Lee, Sang Wroul Song, Byoung Yeop Kim and Kook Young Kim

    Citation: BMC Ophthalmology 2020 20:238

    Content type: Case report

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  20. We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy.

    Authors: Nurdan Gamze Taşlı, Erel Icel, Yücel Karakurt, Turgay Ucak, Adem Ugurlu, Hayati Yilmaz and Emin Murat Akbas

    Citation: BMC Ophthalmology 2020 20:214

    Content type: Research article

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  21. Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK)....

    Authors: Clemence Bonnet, Louis Debillon, Saba Al-Hashimi, Florence Hoogewoud, Dominique Monnet, Jean-Louis Bourges and Antoine Brézin

    Citation: BMC Ophthalmology 2020 20:205

    Content type: Research article

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  26. Healthy corneal epithelium acts as a barrier against damage to the deeper structures in the eye. Failure in the mechanisms of corneal epithelization can lead to persistent epithelial defects of the cornea (PED...

    Authors: Hyun Sik Moon, Lan Li, Hyeon Jeong Yoon, Yong Sok Ji and Kyung Chul Yoon

    Citation: BMC Ophthalmology 2020 20:147

    Content type: Research article

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  28. Several previous studies reported a greater prevalence of dry eye syndrome (DES) among patients with psychiatric diseases. The aim of this study is to investigate the prevalence and risk factors of DES in pati...

    Authors: Chiao-Ying Liang, Wai-Man Cheang, Chun-Yuan Wang, Keng-Hung Lin, Li-Chen Wei, Yu-Yen Chen and Ying-Cheng Shen

    Citation: BMC Ophthalmology 2020 20:123

    Content type: Research article

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  29. The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration....

    Authors: Kimberly M. Brothers, Nicholas A. Stella and Robert M. Q. Shanks

    Citation: BMC Ophthalmology 2020 20:120

    Content type: Research article

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  30. The aim of this study was to evaluate the efficacy and safety of M22 Optimal Pulsed Technology (OPT) applied in patients with age-related cataract and Meibomian gland dysfunction (MGD) in perioperative period.

    Authors: Jinling Ge, Na Liu, Xiaoming Wang, Ying Du, Chaoqing Wang, Zhaorui Li, Jing Li and Lihua Wang

    Citation: BMC Ophthalmology 2020 20:111

    Content type: Research article

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  32. Systemic lupus erythematosus (SLE) can directly affect various part of the ocular system, but there was no comprehensive analysis of ophthalmic disorders of patients with SLE using population-based data. The a...

    Authors: Chun-Shuo Hsu, Chia-Wen Hsu, Ming-Chi Lu and Malcolm Koo

    Citation: BMC Ophthalmology 2020 20:96

    Content type: Research article

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  33. We aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment.

    Authors: Kana Ikemoto, Shinya Kobayashi, Yu Haranosono, Seiko Kozai, Tomoyuki Wada, Hideki Tokushige and Akio Kawamura

    Citation: BMC Ophthalmology 2020 20:89

    Content type: Research article

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  34. The aim of this study was to explore the differences in terms of tear film and meibomian glands (MGs) between young Asian soft contact lens (CL) wearers and non-wearers.

    Authors: Tianpu Gu, Lu Zhao, Zhuzhu Liu, Shaozhen Zhao, Hong Nian and Ruihua Wei

    Citation: BMC Ophthalmology 2020 20:84

    Content type: Research article

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  35. Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this st...

    Authors: Anita Csorba, Erika Maka, Otto Alexander Maneschg, Attila Szabó, Nóra Szentmáry, Mária Csidey, Miklós Resch, László Imre, Krisztina Knézy and Zoltán Zsolt Nagy

    Citation: BMC Ophthalmology 2020 20:73

    Content type: Research article

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  36. To investigate the prevalence of pterygium and associated factors in Han and Mongolian adults at four survey sites in Inner Mongolia, China.

    Authors: Yuhan Wang, Guangliang Shan, Linyang Gan, Yonggang Qian, Ting Chen, Hailing Wang, Xiaodan Pan, Wenrui Wang, Li Pan, Xia Zhang, Meng Wang, Jin Ma and Yong Zhong

    Citation: BMC Ophthalmology 2020 20:45

    Content type: Research article

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  37. Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each malapposition affected post-penetrating keratoplasty (post-PK) visual outcomes. In this study, we revie...

    Authors: Yujin Zhao, Hong Zhuang, Jiaxu Hong, Lijia Tian and Jianjiang Xu

    Citation: BMC Ophthalmology 2020 20:41

    Content type: Research article

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  38. Corneal infections with antibiotic-resistant microorganisms are an increasingly difficult management challenge and chemically or photochemically cross-linking the cornea for therapy presents a unique approach ...

    Authors: Daeryl E. Amponin, Joanna Przybek-Skrzypecka, Mariya Zyablitskaya, Anna Takaoka, Leejee H. Suh, Takayuki Nagasaki, Stephen L. Trokel and David C. Paik

    Citation: BMC Ophthalmology 2020 20:28

    Content type: Research article

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  39. Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue and disturbance in vision. DED affects patients’ quality of life and leads...

    Authors: Yousef Shanti, Reham Shehada, May M. Bakkar and Jamal Qaddumi

    Citation: BMC Ophthalmology 2020 20:26

    Content type: Research article

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  40. Radiation therapy (RT) is the treatment of choice in patients with low-grade ocular adenexal mucosa-associated lymphoid tissue lymphoma (OAML) and many of them experience post-RT dry eye with varying severity....

    Authors: Sung Eun Kim, Hee Jung Yang and Suk-Woo Yang

    Citation: BMC Ophthalmology 2020 20:24

    Content type: Research article

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  41. We sought to describe corneal epithelial changes after using epidermal (EGFR) or fibroblast growth factor receptor (FGFR) inhibitors as chemotherapy and to clarify incidence and prognosis.

    Authors: Eunhae Shin, Dong Hui Lim, Jisang Han, Do-Hyun Nam, Keunchil Park, Myung-Ju Ahn, Won Ki Kang, Jeeyun Lee, Jin Seok Ahn, Se-Hoon Lee, Jong-Mu Sun, Hyun Ae Jung and Tae-Young Chung

    Citation: BMC Ophthalmology 2020 20:19

    Content type: Research article

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  44. Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide ...

    Authors: Wenbo Hou, Xuguang Sun, Jun Feng, Yang Zhang and Zhiqun Wang

    Citation: BMC Ophthalmology 2019 19:262

    Content type: Research article

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  46. We aimed to investigate the effect of short-term orthokeratology lens or frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia.

    Authors: Shuyi Yuan, Shuxian Zhang, Yanglin Jiang and Lihua Li

    Citation: BMC Ophthalmology 2019 19:242

    Content type: Research article

    Published on:

  47. Repeated surgery excisions could induce obvious irregular astigmatism in patients with recurrent pterygium. Our study is aimed to illustrate the effect of adjunct excimer laser phototherapeutic keratectomy (PT...

    Authors: Di Chen, Xiaowei Liu, Qin Long, Zhonghai Wang and Ying Li

    Citation: BMC Ophthalmology 2019 19:238

    Content type: Research article

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  48. Anterior high-resolution optical coherence tomography (HR-OCT) is a novel non-invasive in vivo imaging modality that can assist in the diagnosis and management of various ophthalmic pathologies. The implementa...

    Authors: Yi-Syun Shen, Joseph L. Hu and Chao-Chien Hu

    Citation: BMC Ophthalmology 2019 19:235

    Content type: Case report

    Published on:

  49. Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cor...

    Authors: Yue Zhou, Yuqing Chen, Suiyue Wang, Fangyuan Qin and Liya Wang

    Citation: BMC Ophthalmology 2019 19:226

    Content type: Research article

    Published on:

  50. Corneal transplantations are surgeries performed for irreparable corneal diseases and damage. However, there is a gap between the number of potential recipients and the number of donor corneas available. The m...

    Authors: Seth Lartey, Ellen K. Antwi-Adjei, Solomon Agyapong, Abdul-Kabir Mohammed, Derrick N. O. Mensah and Edward S. Genego

    Citation: BMC Ophthalmology 2019 19:224

    Content type: Research article

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