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Glaucoma

This section takes submissions looking at all aspects of the prevention, diagnosis and management of glaucoma. The section also welcomes basic science studies including molecular and cellular biology, genetics, pathophysiology and epidemiology. Prospective clinical studies, especially randomized controlled trials are encouraged.

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  1. Various surgical techniques have been described, to be combined with cataract surgery in glaucoma patients, aiming for an additional reduction of intraocular pressure (IOP), hence minimizing the burden of anti...

    Authors: Magda A. Torky, Yousef A. Alzafiri, Ameera G. Abdelhameed and Eman A. Awad

    Citation: BMC Ophthalmology 2021 21:53

    Content type: Research article

    Published on:

  2. Adherence to chronic therapies is crucial to prevent the progression of disease, such as glaucoma. However, only a limited number of studies have investigated them using real-world data in Japan. This study ai...

    Authors: Chikako Shirai, Nobushige Matsuoka and Toru Nakazawa

    Citation: BMC Ophthalmology 2021 21:52

    Content type: Research article

    Published on:

  3. Precise optic disc size measurements based on anatomically exact disc margins are fundamental for a correct assessment of glaucoma suspects. Computerized imaging techniques, such as confocal-scanning-laser-tom...

    Authors: Ioana Maria Cazana, Daniel Böhringer, Thomas Reinhard, Charlotte Evers, Diana Engesser, Alexandra Anton and Jan Lübke

    Citation: BMC Ophthalmology 2021 21:31

    Content type: Research article

    Published on:

  4. Severe congenital ophthalmological malformations and glaucoma might be an important occasional feature in patients with Coffin-Siris syndrome (CSS), especially Coffin-Siris syndrome 9 (CSS9, OMIM #615866) caus...

    Authors: Heidi Diel, Can Ding, Franz Grehn, Panagiotis Chronopoulos, Oliver Bartsch and Esther M. Hoffmann

    Citation: BMC Ophthalmology 2021 21:28

    Content type: Case report

    Published on:

    The Correction to this article has been published in BMC Ophthalmology 2021 21:57

  5. To compare the aqueous humor (AH) and the serum clusterin levels of patients with pseudoexfoliation syndrome (PEX), pseudoexfoliation glaucoma (PEXG), and primary open-angle glaucoma (POAG) with each other and...

    Authors: Fuat Yavrum, Ufuk Elgin, Zeynep Adiyaman Kocer, Vildan Fidanci and Emine Sen

    Citation: BMC Ophthalmology 2021 21:25

    Content type: Research article

    Published on:

  6. Implantation of the posterior chamber phakic intraocular lens has been widely performed to correct high and extreme myopia. Chronic intraocular pressure (IOP) elevation may occur in its late postoperative peri...

    Authors: Rongrong Hu, Wei Xu, Baishuang Huang and Xiaoyu Wang

    Citation: BMC Ophthalmology 2021 21:20

    Content type: Case report

    Published on:

  7. Early detection of glaucoma is paramount to maintain patients’ eyesight, however glaucomatous vision loss tends to begin in the periphery with up to 50% of patients unaware they are affected. Because glaucomat...

    Authors: Anna Neustaeter, Ilja Nolte, Harold Snieder and Nomdo M. Jansonius

    Citation: BMC Ophthalmology 2021 21:18

    Content type: Study protocol

    Published on:

  8. Sturge-Weber syndrome (SWS) is a sporadic congenital disorder, characterized by unilateral facial nevus flammeus associated with ipsilateral glaucoma, choroidal angioma and leptomeningeal hemangiomas. SWS can ...

    Authors: Hongxi Wang, Nana Dong, Li Tan and Chukai Huang

    Citation: BMC Ophthalmology 2021 21:6

    Content type: Case report

    Published on:

  9. The aim of this retrospective study was to compare the efficacy and safety profile of a single XEN-microstent in different types of primary and secondary open angle glaucoma.

    Authors: Marc Schargus, Theresa Theilig, Matus Rehak, Catharina Busch, Caroline Bormann and Jan Darius Unterlauft

    Citation: BMC Ophthalmology 2020 20:490

    Content type: Research article

    Published on:

  10. Anterior uveitis secondary to topical brimonidine administration is rare and not well-defined. In glaucoma patients using brimonidine, one must consider this phenomenon to avoid mis-diagnosis and over-treatmen...

    Authors: Susanne Hopf, Karl Mercieca, Norbert Pfeiffer and Verena Prokosch-Willing

    Citation: BMC Ophthalmology 2020 20:489

    Content type: Research article

    Published on:

  11. To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).

    Authors: Yue Wu, Lulu Huang, Yixin Liu, Li Xu and Wenyi Guo

    Citation: BMC Ophthalmology 2020 20:477

    Content type: Research article

    Published on:

  12. Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the dise...

    Authors: Hannah Weindler, Martin S. Spitzer, Maximilian Schultheiß and Robert Kromer

    Citation: BMC Ophthalmology 2020 20:444

    Content type: Research article

    Published on:

  13. To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accura...

    Authors: A. R. Kee, V. C. H. Yip, E. L. T. Tay, C. W. Lim, J. Cheng, H. Y. Teo, C. H. Chua and L. W. L. Yip

    Citation: BMC Ophthalmology 2020 20:440

    Content type: Research article

    Published on:

  14. Central retinal vein occlusion is a variable disease pattern. Preliminary stages of a complete occlusion of the central vein, wich are subsumed under the term venous stasis retinopathy, may occur as transient ...

    Authors: Julia V. Stingl, Laura Ponce Nunez, Alexander K. Schuster and Esther M. Hoffmann

    Citation: BMC Ophthalmology 2020 20:428

    Content type: Case report

    Published on:

  15. Driving simulators are a safe alternative to on-road vehicles for studying driving behavior in glaucoma drivers. Visual field (VF) loss severity is associated with higher driving simulator crash risk, though m...

    Authors: David E. Anderson, John P. Bader, Emily A. Boes, Meghal Gagrani, Lynette M. Smith, Jideofor K. Ndulue, Sachin Kedar, Vikas Gulati, Deepta A. Ghate and Matthew Rizzo

    Citation: BMC Ophthalmology 2020 20:419

    Content type: Research article

    Published on:

  16. Glaucoma surgery have been developed to lower intraocular pressure in a less invasive manner than traditional glaucoma surgery. The purpose of this article is to determine the outcome of using combined phacoem...

    Authors: Juan Carlos Izquierdo, Josefina Mejías, Laura Cañola-R, Natalia Agudelo and Bárbara Rubio

    Citation: BMC Ophthalmology 2020 20:406

    Content type: Research article

    Published on:

  17. The causal effects of plasma lipid concentrations and the risk of primary open angle glaucoma (POAG) are still unclear. Thus, the purpose of this study was to identify, applying a two-sample Mendelian randomiz...

    Authors: Mengqiao Xu, Shengguo Li, Jundong Zhu, Dawei Luo, Weitao Song and Minwen Zhou

    Citation: BMC Ophthalmology 2020 20:390

    Content type: Research article

    Published on:

  18. To compare the efficacy and safety of ab externo circumferential trabeculotomy (ECT) and canaloplasty on primary open angle glaucoma (POAG) patients with failed filtering surgery and intact schlemm’s canal (SC).

    Authors: Huaizhou Wang, Chen Xin, Ying Han, Yan Shi, Sarah Ziaei and Ningli Wang

    Citation: BMC Ophthalmology 2020 20:389

    Content type: Research article

    Published on:

  19. Nanophthalmos has a significant genetic background and disease-causing mutations have been recently been reported in the myelin regulatory factor (MYRF) gene. We report clinical features in a patient with nanopht...

    Authors: Joshua Hagedorn, Armin Avdic, Michael J. Schnieders, Benjamin R. Roos, Young H. Kwon, Arlene V. Drack, Erin A. Boese and John H. Fingert

    Citation: BMC Ophthalmology 2020 20:388

    Content type: Case report

    Published on:

  20. The aim of the study is to evaluate the diagnostic ability of OCT parameters and retinal ganglion cells (RGCs) count in identify glaucomatous disease in myopic preperimetric eyes.

    Authors: Teresa Rolle, Beatrice Bonetti, Alberto Mazzucco and Laura Dallorto

    Citation: BMC Ophthalmology 2020 20:373

    Content type: Research article

    Published on:

  21. Eyemate® is a system for the continual monitoring of intraocular pressure (IOP), composed of an intraocular sensor, and a hand-held reader device. As the eyemate®-IO sensor communicates with the hand-held read...

    Authors: Azzurra Invernizzi, Shereif Haykal, Valeria Lo Faro, Vincenzo Pennisi and Lars Choritz

    Citation: BMC Ophthalmology 2020 20:357

    Content type: Research article

    Published on:

  22. To investigate the distribution of peripheral anterior chamber depth (ACD) and the relationship between peripheral ACD and gonioscopy compared to other ocular parameters for primary angle closure disease (PACD...

    Authors: Qin Luo, Wenwen Xue, Yin Yuan, Chaowei Fu, Jiangnan He, Haidong Zou, Xiaowei Tong, Richard K. Lee and Ling Ge

    Citation: BMC Ophthalmology 2020 20:353

    Content type: Research article

    Published on:

  23. To determine if 3% diquafosol (DQS) can preserve the meibomian gland morphology in glaucoma patients treated with prostaglandin analogs (PGA) for a 12-month follow-up period.

    Authors: Yue Guo, Jun Young Ha, He Long Piao, Mi Sun Sung and Sang Woo Park

    Citation: BMC Ophthalmology 2020 20:277

    Content type: Research article

    Published on:

  24. Ripasudil is approved in Japan for glaucoma or ocular hypertension (OH) when other treatments are ineffective or cannot be administered. Its long-term safety and efficacy are being examined in a post-marketing...

    Authors: Hidenobu Tanihara, Takahiko Kakuda, Tetsuro Sano, Takashi Kanno and Ryoji Gunji

    Citation: BMC Ophthalmology 2020 20:275

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Ophthalmology 2020 20:362

  25. Autosomal recessive bestrophinopathy (ARB) is caused by homozygous or compound heterozygous mutations in the BEST1 gene and always accompanied with refractory angle-closure glaucoma (ACG). The exact mechanism for...

    Authors: Yan Shi, Jiaxin Tian, Ying Han, Julius Oatts and Ningli Wang

    Citation: BMC Ophthalmology 2020 20:271

    Content type: Case report

    Published on:

  26. To examine the speed and accuracy of saccadic eye movements during a novel eye tracking threshold visual field assessment and determine whether eye movement parameters may improve ability to detect glaucoma.

    Authors: Andrew J. Tatham, Ian C. Murray, Alice D. McTrusty, Lorraine A. Cameron, Antonios Perperidis, Harry M. Brash, Brian W. Fleck and Robert A. Minns

    Citation: BMC Ophthalmology 2020 20:259

    Content type: Research article

    Published on:

  27. To determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops.

    Authors: Makoto Gozawa, Yoshihiro Takamura, Kentaro Iwasaki, Shogo Arimura and Masaru Inatani

    Citation: BMC Ophthalmology 2020 20:244

    Content type: Research article

    Published on:

  28. To compare the efficacy of phacoemulsification (PKE) combined with nonpenetrating deep sclerectomy (NPDS) with mitomycin C (MMC) versus XEN® gel stent with MMC.

    Authors: Vincent Theillac, Esther Blumen-Ohana, Jad Akesbi, Pascale Hamard, Alexandre Sellam, Emmanuelle Brasnu, Christophe Baudouin, Antoine Labbe and Jean-Philippe Nordmann

    Citation: BMC Ophthalmology 2020 20:231

    Content type: Research article

    Published on:

  29. Poor persistence with glaucoma therapy can lead to disease progression and subsequent blindness. Persistence with second-line glaucoma combination treatment in a Japanese real-world setting and whether it diff...

    Authors: Kenji Kashiwagi, Eriko Chono, Sarah Koesters and Poh Sin Yap

    Citation: BMC Ophthalmology 2020 20:223

    Content type: Research article

    Published on:

  30. To investigate the safety and efficacy of scleral concave pool trabeculectomy (SCPT) combined phacoemulsification for eyes with coexisting cataract and primary open-angle glaucoma (POAG).

    Authors: Xiangxiang Ye, Yongjun Qi, Jianhua Deng, Yang Yang, Ting Mo, Mao Xu and Wanjun Liu

    Citation: BMC Ophthalmology 2020 20:222

    Content type: Research article

    Published on:

  31. To introduce a novel protocol to treat refractory acute primary angle closure (APAC): transscleral cyclophotocoagulation (TCP) followed by cataract surgery.

    Authors: Wei Liu, Luning Qin, Chenjia Xu, Dandan Huang, Ruru Guo, Jian Ji and Nomdo M. Jansonius

    Citation: BMC Ophthalmology 2020 20:209

    Content type: Research article

    Published on:

  32. To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH).

    Authors: Maiko Abe, Kazuko Omodaka, Tsutomu Kikawa and Toru Nakazawa

    Citation: BMC Ophthalmology 2020 20:199

    Content type: Research article

    Published on:

  33. The surgical management of glaucoma associated with Axenfeld-Rieger Syndrome (ARS) is poorly described in the literature. The goal of this study is to compare the effectiveness of various glaucoma surgeries on...

    Authors: Emily M. Zepeda, Kari Branham, Sayoko E. Moroi and Brenda L. Bohnsack

    Citation: BMC Ophthalmology 2020 20:172

    Content type: Research article

    Published on:

  34. To investigate the long term surgical outcomes of cataract surgery in severe and end stage glaucoma patients with preoperative intraocular pressure less than 21 mmHg, and to detect the associated factors.

    Authors: Lin Fu, Yau Kei Chan, Junhua Li, Li Nie, Na Li and Weihua Pan

    Citation: BMC Ophthalmology 2020 20:160

    Content type: Research article

    Published on:

  35. In order to detect glaucomatous optic nerve damages early on and evaluate the severity of glaucoma, a previously developed analytic method based on photographic retinal nerve fiber layer (RNFL) angle defect wa...

    Authors: Alexander Chen, Ing-Chou Lai, Wan-Hua Cho, Hung-Yin Lai, Pei-Wen Lin, Pei-Chang Wu and Ming-Tse Kuo

    Citation: BMC Ophthalmology 2020 20:141

    Content type: Research article

    Published on:

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