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Inflammatory eye diseases

This section considers articles on all aspects of the prevention, diagnosis and management of inflammatory eye diseases as well as related molecular genetics, pathophysiology and epidemiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. Trachoma is a neglected eye disease and an important cause of preventable corneal blindness. In endemic areas, initial infection can occur in early childhood and following a recurrent episodes, it progresses t...

    Authors: Mesfin Wudu Kassaw, Ayele Mamo Abebe, Kirubel Dagnaw Tegegne, Mikiyas Amare Getu and Woldemichael Tadesse Bihonegn

    Citation: BMC Ophthalmology 2020 20:346

    Content type: Research article

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  2. Substance P (SP) is a nociceptive tachykinin which regulates the immune inflammatory reactions including monocyte chemoattractant protein 1 (MCP-1) production. Sequential second-eye cataract surgery patients o...

    Authors: Xianhui Gong, Yueping Ren, Xiuxiu Fang, Junyong Cai and E. Song

    Citation: BMC Ophthalmology 2020 20:339

    Content type: Research article

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  3. Orbital invasive aspergillosis infection is rare life-threatening infection, most commonly seen in immunocompromised patients and extremely rare in individuals without risk factors. Here we present a rare case...

    Authors: Jiahui Wu, Hao Zhou, Ruili Wei and Jinwei Cheng

    Citation: BMC Ophthalmology 2020 20:330

    Content type: Case report

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  4. Age-related Macular Degeneration (AMD) is a complex eye disease, which is genetically associated with different susceptibility loci. We planned to investigate the possible association of Complement Factor B (C...

    Authors: Nasrin Roshanipour, Maryam Ghaffari Laleh, Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Masoud Soheilian, Alireza Javadzadeh and Mehdi Yaseri

    Citation: BMC Ophthalmology 2020 20:323

    Content type: Research article

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  8. To describe the clinical characteristics and analyze the predictive factors associated with improved visual acuity of 359 patients with infectious endophthalmitis.

    Authors: Zhao Gao, Yunda Zhang, Xiaohong Gao, Ximei Zhang, Tao Ma, Gaiyun Li, Jingjing Wang and Hua Yan

    Citation: BMC Ophthalmology 2020 20:256

    Content type: Research article

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  10. This study aimed to assess and compare the clinical value of aqueous humor polymerase chain reaction (PCR) and serologic tests in patients diagnosed with suspected infectious uveitis.

    Authors: Wungrak Choi, Hyun Goo Kang, Eun Young Choi, Sung Soo Kim, Chan Yun Kim, Hyoung Jun Koh, Sung Chul Lee and Min Kim

    Citation: BMC Ophthalmology 2020 20:242

    Content type: Research article

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  12. The usefulness of povidone-iodine as an alternative to antimicrobial agents, for endophthalmitis, has recently been documented. We report a case of endogenous endophthalmitis successfully treated with intravit...

    Authors: Hiroki Tanaka, Hiroyuki Nakashizuka, Yoshinobu Mizuno and Takayuki Hattori

    Citation: BMC Ophthalmology 2020 20:217

    Content type: Case report

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  13. There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamet...

    Authors: Wei Zhang, Han Han, Kang Feng, Xiaohong Wang, Mei Du, Xiangda Meng, Yuanyuan Liu, Bo Huang, Rodrigo Brant and Hua Yan

    Citation: BMC Ophthalmology 2020 20:208

    Content type: Research article

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  15. The purpose of this study was to evaluate the role of systemic steroids in post-procedural endophthalmitis as the role of intravitreal steroids in treatment algorithms of endophthalmitis remain controversial.

    Authors: Christopher D. Conrady, Richard M. Feist Jr, Albert T. Vitale and Akbar Shakoor

    Citation: BMC Ophthalmology 2020 20:181

    Content type: Research article

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  17. Inflammation of RPE cells led to different kinds of eye diseases and affected the normal function of the retina. Furthermore, higher levels of ROCK1 and ROCK2 induced injury of endothelial cells and many infla...

    Authors: Zhao Gao, Qiang Li, Yunda Zhang, Xiaohong Gao, Haiyan Li and Zhigang Yuan

    Citation: BMC Ophthalmology 2020 20:134

    Content type: Research article

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  18. Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE)...

    Authors: Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M. Nishiguchi, Hiroshi Kunikata and Toru Nakazawa

    Citation: BMC Ophthalmology 2020 20:126

    Content type: Research article

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  19. Outcome measurements currently used in chronic uveitis care fail to cover the full patient perspective. The aim of this study is to develop a conceptual model of the factors that adult patients with chronic uv...

    Authors: Aline C. Stolk-Vos, Hamasa Kasigar, Karlijn J. Nijmeijer, Tom O. Missotten, Jan J. Busschbach, Joris J. van de Klundert and Leonieke W. Kranenburg

    Citation: BMC Ophthalmology 2020 20:125

    Content type: Research article

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  20. Eye infection is a public health problem in developing countries including Ethiopia. Bacteria are major causative agents of eye infections that can lead to loss of vision. The objective of this study was to de...

    Authors: Ahmed Adem Mohammed, Musa Mohammed Ali and Mengistu Hailemariam Zenebe

    Citation: BMC Ophthalmology 2020 20:124

    Content type: Research article

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  22. Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading...

    Authors: Kanae Fukutsu, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Satoru Kase, Kayo Suzuki, Hiroshi Shimizu, Yukiko Shibata, Fumihiko Yamawaki, Masahiro Onozawa and Susumu Ishida

    Citation: BMC Ophthalmology 2020 20:94

    Content type: Case report

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  23. Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation d...

    Authors: Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Salai Madhumathi Parkunan, C. Blake Randall, Rachel L. Staats and Michelle C. Callegan

    Citation: BMC Ophthalmology 2018 18:96

    Content type: Research article

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  24. Clostridium perfringens is an uncommon pathogen in endophthalmitis, causing rapid destruction of ocular tissues. Clostridium perfringens infection typically occurs after penetrating injury with soil-contaminated ...

    Authors: Ghita Guedira, Nabil Taright, Hélène Blin, Thameur Fattoum, Jordan Leroy, Youssef El Samad, Solange Milazzo and Farida Hamdad

    Citation: BMC Ophthalmology 2018 18:88

    Content type: Case report

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  25. Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease that affects the Retinal Pigment Epithelium and outer retina. The purpose of this study was to describe its...

    Authors: Olivia Xerri, Sawsen Salah, Dominique Monnet and Antoine P. Brézin

    Citation: BMC Ophthalmology 2018 18:76

    Content type: Research article

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  26. Graves’ disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves’ Oph...

    Authors: Andrea Rau, Matthias Klopfer, Niklas Rommel, Mechthild Rau-Fornefeld and Andreas Kolk

    Citation: BMC Ophthalmology 2018 18:56

    Content type: Case report

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  28. Cytomegalovirus (CMV) retinitis is an opportunistic infection that primarily affects immunocompromised individuals. Intravitreal ganciclovir injection monotherapy or in combination with systemic anti-CMV thera...

    Authors: Lawrence P. L. Iu, Michelle C. Y. Fan, Wai-Ching Lam and Ian Y. H. Wong

    Citation: BMC Ophthalmology 2018 18:36

    Content type: Case report

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  29. Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained...

    Authors: Joo Yeon Kim, Ji Hwan Lee, Christopher Seungkyu Lee and Sung Chul Lee

    Citation: BMC Ophthalmology 2018 18:28

    Content type: Case report

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  30. Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however...

    Authors: Chan Zhao, Fangtian Dong, Fei Gao, Xinshu Liu, Minghang Pei, Shanshan Jia and Meifen Zhang

    Citation: BMC Ophthalmology 2018 18:6

    Content type: Research article

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  31. Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial ...

    Authors: Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi and Endre V. Nagy

    Citation: BMC Ophthalmology 2018 18:5

    Content type: Case report

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  32. To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis.

    Authors: Sibylle Winterhalter, Uwe Diedrich Behrens, Daniel Salchow, Antonia M. Joussen and Uwe Pleyer

    Citation: BMC Ophthalmology 2017 17:252

    Content type: Research article

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  33. To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model.

    Authors: Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J. Gonzalez-Lopez, Peter K. F. Addison, Mark Westcott and Carlos E. Pavesio

    Citation: BMC Ophthalmology 2017 17:245

    Content type: Research article

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  34. Nivolumab is a fully human antibody which is routinely used at first therapy for metastatic melanoma. Usually, side effects are immune-related adverse events. We report a case of a man who developed bilateral ...

    Authors: Claire Theillac, Morgane Straub, Anne-Laure Breton, Luc Thomas and Stéphane Dalle

    Citation: BMC Ophthalmology 2017 17:227

    Content type: Case report

    Published on:

  35. Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses ...

    Authors: Mirinae Kim, Seung Yong Choi and Young-Hoon Park

    Citation: BMC Ophthalmology 2017 17:225

    Content type: Research article

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  37. We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature.

    Authors: Wei Fang, Jiuke Li, Hu-Shan Cui, Xiaohong Jin, Jing Zhai, Yuanmin Dai and Yumin Li

    Citation: BMC Ophthalmology 2017 17:190

    Content type: Case report

    Published on:

  38. Echinococcosis is a dangerous zoonotic parasitic disease. Ocular echinococcosis is very rare, especially the hydatid cysts in subretinal space. We present a case of subretinal echinococcosis and management.

    Authors: Chunying Guo, Ruilin Zhu, Jianxing Qiu, Lina Zhu and Liu Yang

    Citation: BMC Ophthalmology 2017 17:185

    Content type: Case report

    Published on:

  39. Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jordan. This study aims to assess the awareness of these ocular diseases among Jordanian population.

    Authors: Mera F. Haddad, May M. Bakkar and Nour Abdo

    Citation: BMC Ophthalmology 2017 17:177

    Content type: Research article

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  40. To analyse the associated factors, diagnosis, clinical manifestations and therapeutic effects of Acanthamoeba keratitis at a tertiary ophthalmic centre in Southern China.

    Authors: Jing Zhong, Xingyi Li, Yuqing Deng, Ling Chen, Shiyou Zhou, Weilan Huang, Shiqi Lin and Jin Yuan

    Citation: BMC Ophthalmology 2017 17:175

    Content type: Research article

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  41. To report a case of uveitis and neuroretinal detachment in a patient treated with Trametinib and Dabrafenib due to metastatic cutaneous melanoma stage IV.

    Authors: Stephanie Sarny, Michael Neumayer, Julian Kofler and Yosuf El-Shabrawi

    Citation: BMC Ophthalmology 2017 17:146

    Content type: Case report

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  45. Uveitis is an eye inflammatory disease, which is sometimes associated with underlying systemic disease. Interleukin-23 plays an important role in autoimmune disease. The aim of this meta-analysis was to evalua...

    Authors: Jae Hyun Jung, Gwan Gyu Song, Jae-Hoon Kim, Young Ho Seo and Sung Jae Choi

    Citation: BMC Ophthalmology 2017 17:81

    Content type: Research article

    Published on:

  47. Human toxocariasis, caused by Toxocara canis, T. cati, and T. vitulorum of dogs, cats and ruminants respectively, is recognized as an important zoonotic infection worldwide. The typical clinical syndromes of toxo...

    Authors: Devika Iddawela, Kiruthiha Ehambaram and Pemindra Bandara

    Citation: BMC Ophthalmology 2017 17:50

    Content type: Research article

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  48. Ocular allergy is a growing public health problem that greatly impacts the day-to-day life of sufferers and their families. Other aspects of their activities of daily living such as schooling, professional, an...

    Authors: Samuel Kyei, Bernard Tettey, Kofi Asiedu and Agnes Awuah

    Citation: BMC Ophthalmology 2016 16:190

    Content type: Research article

    Published on:

  49. This was an indirect comparison of the effectiveness of intravitreal aflibercept (IVT-AFL) 2 mg every 8 weeks after 5 initial monthly doses (or if different periods, after an initial monthly dosing period) (2q...

    Authors: Jean-Francois Korobelnik, Jos Kleijnen, Shona H Lang, Richard Birnie, Regina M Leadley, Kate Misso, Gill Worthy, Dominic Muston and Diana V Do

    Citation: BMC Ophthalmology 2015 15:52

    Content type: Research article

    Published on:

  50. This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geograph...

    Authors: Diane E Balderson, Gengqian Cai, Michael A Fries, David M Kleinman, Megan M McLaughlin, Trupti M Trivedi, John I Wurzelmann and Sheila B Young

    Citation: BMC Ophthalmology 2015 15:42

    Content type: Research article

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