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Inflammatory eye diseases

This section considers articles on all aspects of the prevention, diagnosis and management of inflammatory eye diseases as well as related molecular genetics, pathophysiology and epidemiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

  1. Content type: Research article

    Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation d...

    Authors: Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Salai Madhumathi Parkunan, C. Blake Randall, Rachel L. Staats and Michelle C. Callegan

    Citation: BMC Ophthalmology 2018 18:96

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  2. Content type: Case report

    Clostridium perfringens is an uncommon pathogen in endophthalmitis, causing rapid destruction of ocular tissues. Clostridium perfringens infection typically occurs after penetrating injury with soil-contaminated ...

    Authors: Ghita Guedira, Nabil Taright, Hélène Blin, Thameur Fattoum, Jordan Leroy, Youssef El Samad, Solange Milazzo and Farida Hamdad

    Citation: BMC Ophthalmology 2018 18:88

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  3. Content type: Research article

    Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease that affects the Retinal Pigment Epithelium and outer retina. The purpose of this study was to describe its...

    Authors: Olivia Xerri, Sawsen Salah, Dominique Monnet and Antoine P. Brézin

    Citation: BMC Ophthalmology 2018 18:76

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  4. Content type: Case report

    Graves’ disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves’ Oph...

    Authors: Andrea Rau, Matthias Klopfer, Niklas Rommel, Mechthild Rau-Fornefeld and Andreas Kolk

    Citation: BMC Ophthalmology 2018 18:56

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  6. Content type: Case report

    Cytomegalovirus (CMV) retinitis is an opportunistic infection that primarily affects immunocompromised individuals. Intravitreal ganciclovir injection monotherapy or in combination with systemic anti-CMV thera...

    Authors: Lawrence P. L. Iu, Michelle C. Y. Fan, Wai-Ching Lam and Ian Y. H. Wong

    Citation: BMC Ophthalmology 2018 18:36

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  7. Content type: Case report

    Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained...

    Authors: Joo Yeon Kim, Ji Hwan Lee, Christopher Seungkyu Lee and Sung Chul Lee

    Citation: BMC Ophthalmology 2018 18:28

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  8. Content type: Research article

    Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however...

    Authors: Chan Zhao, Fangtian Dong, Fei Gao, Xinshu Liu, Minghang Pei, Shanshan Jia and Meifen Zhang

    Citation: BMC Ophthalmology 2018 18:6

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  9. Content type: Case report

    Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial ...

    Authors: Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi and Endre V. Nagy

    Citation: BMC Ophthalmology 2018 18:5

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  10. Content type: Research article

    To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis.

    Authors: Sibylle Winterhalter, Uwe Diedrich Behrens, Daniel Salchow, Antonia M. Joussen and Uwe Pleyer

    Citation: BMC Ophthalmology 2017 17:252

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  11. Content type: Research article

    To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model.

    Authors: Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J. Gonzalez-Lopez, Peter K. F. Addison, Mark Westcott and Carlos E. Pavesio

    Citation: BMC Ophthalmology 2017 17:245

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  12. Content type: Case report

    Nivolumab is a fully human antibody which is routinely used at first therapy for metastatic melanoma. Usually, side effects are immune-related adverse events. We report a case of a man who developed bilateral ...

    Authors: Claire Theillac, Morgane Straub, Anne-Laure Breton, Luc Thomas and Stéphane Dalle

    Citation: BMC Ophthalmology 2017 17:227

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  13. Content type: Research article

    Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses ...

    Authors: Mirinae Kim, Seung Yong Choi and Young-Hoon Park

    Citation: BMC Ophthalmology 2017 17:225

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  15. Content type: Case report

    We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature.

    Authors: Wei Fang, Jiuke Li, Hu-Shan Cui, Xiaohong Jin, Jing Zhai, Yuanmin Dai and Yumin Li

    Citation: BMC Ophthalmology 2017 17:190

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  16. Content type: Case report

    Echinococcosis is a dangerous zoonotic parasitic disease. Ocular echinococcosis is very rare, especially the hydatid cysts in subretinal space. We present a case of subretinal echinococcosis and management.

    Authors: Chunying Guo, Ruilin Zhu, Jianxing Qiu, Lina Zhu and Liu Yang

    Citation: BMC Ophthalmology 2017 17:185

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  17. Content type: Research article

    Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jordan. This study aims to assess the awareness of these ocular diseases among Jordanian population.

    Authors: Mera F. Haddad, May M. Bakkar and Nour Abdo

    Citation: BMC Ophthalmology 2017 17:177

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  18. Content type: Research article

    To analyse the associated factors, diagnosis, clinical manifestations and therapeutic effects of Acanthamoeba keratitis at a tertiary ophthalmic centre in Southern China.

    Authors: Jing Zhong, Xingyi Li, Yuqing Deng, Ling Chen, Shiyou Zhou, Weilan Huang, Shiqi Lin and Jin Yuan

    Citation: BMC Ophthalmology 2017 17:175

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  19. Content type: Case report

    To report a case of uveitis and neuroretinal detachment in a patient treated with Trametinib and Dabrafenib due to metastatic cutaneous melanoma stage IV.

    Authors: Stephanie Sarny, Michael Neumayer, Julian Kofler and Yosuf El-Shabrawi

    Citation: BMC Ophthalmology 2017 17:146

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  23. Content type: Research article

    Uveitis is an eye inflammatory disease, which is sometimes associated with underlying systemic disease. Interleukin-23 plays an important role in autoimmune disease. The aim of this meta-analysis was to evalua...

    Authors: Jae Hyun Jung, Gwan Gyu Song, Jae-Hoon Kim, Young Ho Seo and Sung Jae Choi

    Citation: BMC Ophthalmology 2017 17:81

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  25. Content type: Research article

    Human toxocariasis, caused by Toxocara canis, T. cati, and T. vitulorum of dogs, cats and ruminants respectively, is recognized as an important zoonotic infection worldwide. The typical clinical syndromes of toxo...

    Authors: Devika Iddawela, Kiruthiha Ehambaram and Pemindra Bandara

    Citation: BMC Ophthalmology 2017 17:50

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  26. Content type: Research article

    Ocular allergy is a growing public health problem that greatly impacts the day-to-day life of sufferers and their families. Other aspects of their activities of daily living such as schooling, professional, an...

    Authors: Samuel Kyei, Bernard Tettey, Kofi Asiedu and Agnes Awuah

    Citation: BMC Ophthalmology 2016 16:190

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  27. Content type: Research article

    This was an indirect comparison of the effectiveness of intravitreal aflibercept (IVT-AFL) 2 mg every 8 weeks after 5 initial monthly doses (or if different periods, after an initial monthly dosing period) (2q...

    Authors: Jean-Francois Korobelnik, Jos Kleijnen, Shona H Lang, Richard Birnie, Regina M Leadley, Kate Misso, Gill Worthy, Dominic Muston and Diana V Do

    Citation: BMC Ophthalmology 2015 15:52

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  28. Content type: Research article

    This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geograph...

    Authors: Diane E Balderson, Gengqian Cai, Michael A Fries, David M Kleinman, Megan M McLaughlin, Trupti M Trivedi, John I Wurzelmann and Sheila B Young

    Citation: BMC Ophthalmology 2015 15:42

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  29. Content type: Research article

    Bacterial pathogens isolated from dacryocystitis patients are diverse and complex in terms of their distribution, prevalence, and antimicrobial susceptibility pattern. The clinical importance of microbial caus...

    Authors: Yared Assefa, Feleke Moges, Mengistu Endris, Banchamlak Zereay, Bemnet Amare, Damtew Bekele, Solomon Tesfaye, Andargachew Mulu and Yeshambel Belyhun

    Citation: BMC Ophthalmology 2015 15:34

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  30. Content type: Case report

    The rare descriptions, in the literature, of ocular infections due to Pasteurella multocida include: endophtalmitis, keratitis and corneal ulcers, Parinaud’s oculoglandular syndrome, and conjunctivitis. Here, we ...

    Authors: Anthony Corchia, Anne Limelette, Béatrice Hubault, Ailsa Robbins, Anne Quinquenel, Firouze Bani-Sadr and Yohan N’Guyen

    Citation: BMC Ophthalmology 2015 15:21

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  32. Content type: Research article

    Age-related macular degeneration (AMD) is the leading cause of central vision loss in older adults. Anti-retinal autoantibodies (AAbs) have been found in individuals with AMD. The goal of the study was to dete...

    Authors: Grazyna Adamus, Emily Y Chew, Frederick L Ferris and Michael L Klein

    Citation: BMC Ophthalmology 2014 14:154

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  33. Content type: Research article

    Macular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in ...

    Authors: Zsuzsanna Géhl, Kinga Kulcsár, Huba JM Kiss, János Németh, Otto A Maneschg and Miklós D Resch

    Citation: BMC Ophthalmology 2014 14:103

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  34. Content type: Research article

    Acute severe postoperative endophthalmitis may lead to severe vision loss. The aim of this study was the analysis of macular microstructure imaged by spectral domain optical coherence tomography in patients af...

    Authors: Otto Alexander Maneschg, Éva Volek, János Németh, Gábor Márk Somfai, Zsuzsanna Géhl, Irén Szalai and Miklós Dénes Resch

    Citation: BMC Ophthalmology 2014 14:76

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  35. Content type: Case report

    Uveitis sometimes causes hyphema, but severe hyphema as a complication following herpes zoster uveitis has rarely been reported. We report a rare case of zoster sine herpete with unusually severe hyphema.

    Authors: Yoko Okunuki, Junichi Sakai, Takeshi Kezuka and Hiroshi Goto

    Citation: BMC Ophthalmology 2014 14:74

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  36. Content type: Case report

    Changes in choroidal circulation hemodynamics during the course of punctate inner choroidopathy (PIC) remain unknown. The aim of this study was to quantitatively evaluate changes in choroidal blood flow veloci...

    Authors: Kiriko Hirooka, Wataru Saito, Yuki Hashimoto, Michiyuki Saito and Susumu Ishida

    Citation: BMC Ophthalmology 2014 14:73

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  37. Content type: Research article

    A wide range of organisms that enter the eye following ocular trauma can cause endophthalmitis. This study was to investigate the spectrum of pathogens and antibiotic susceptibility of bacterial isolates from ...

    Authors: Chongde Long, Bingqian Liu, Chaochao Xu, Yuan Jing, Zhaohui Yuan and Xiaofeng Lin

    Citation: BMC Ophthalmology 2014 14:34

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  40. Content type: Research article

    The purpose of this retrospective follow-up study is to evaluate the prevalence of patients with thyroid eye disease presenting with apparent unilateral proptosis and determine the occurrence of exophthalmos i...

    Authors: Diego Strianese, Raffaele Piscopo, Andrea Elefante, Manuela Napoli, Chiara Comune, Immacolata Baronissi, Raffaele Liuzzi, Mariantonia Ferrara, Alessia D’alessandro, Pasquale Ruggiero, Pasquale Napolitano, Piergiacomo Grassi, Adriana Iuliano, Carmela Russo, Arturo Brunetti and Giulio Bonavolontà

    Citation: BMC Ophthalmology 2013 13:21

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  41. Content type: Research article

    HIV/AIDS is one of twenty first century’s challenges to human being with protean manifestation affecting nearly all organs of our body. It is causing high morbidity and mortality especially in sub-Saharan Afri...

    Authors: Sisay Bekele, Yeshigeta Gelaw and Fasil Tessema

    Citation: BMC Ophthalmology 2013 13:20

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  43. Content type: Research article

    A prospective, non-randomised, transversal and comparative study, carried out in INOVA Vision Institute and Autonomous University of Aguascalientes. Pterygium is an important illness that affects 22% people fr...

    Authors: Luis Fernando Barba-Gallardo, Javier Ventura-Juárez, David Kershenobich Stalnikowitz, Rafael Gutiérrez-Campos, Eugenia Torres-Bernal and Luis Fernando Torres-Bernal

    Citation: BMC Ophthalmology 2013 13:6

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  44. Content type: Case report

    Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in retinal damage. Paraneoplastic vitelliform retinopathy, a presumed paraneo...

    Authors: Yujuan Wang, Mones S Abu-Asab, Wei Li, Mary E Aronow, Arun D Singh and Chi-Chao Chan

    Citation: BMC Ophthalmology 2012 12:56

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  45. Content type: Research article

    To report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN).

    Authors: Simon RJ Taylor, Robin Hamilton, Claire Y Hooper, Lavnish Joshi, Jiten Morarji, Nitin Gupta and Sue L Lightman

    Citation: BMC Ophthalmology 2012 12:48

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