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Inflammatory eye diseases

This section considers articles on all aspects of the prevention, diagnosis and management of inflammatory eye diseases as well as related molecular genetics, pathophysiology and epidemiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. Sympathetic ophthalmia (SO) is a bilateral diffuse uveitis that can arise after ocular trauma or ocular surgery in the inciting eye. Pars plana vitrectomy (PPV) is one of the risk factors for SO. Several repor...

    Authors: Yasuyuki Takai, Yoshihito Sakanishi, Masahiro Okamoto and Nobuyuki Ebihara

    Citation: BMC Ophthalmology 2021 21:195

    Content type: Case report

    Published on:

  2. The purpose of this study is to investigate the aqueous humor (AH) T lymphocyte subsets and cytokines of acute retinal necrosis (ARN) to elucidate the immunologic inflammatory features of this disorder.

    Authors: Hao Kang, Yunbo Wei, Ming Liu, Di Yu and Yong Tao

    Citation: BMC Ophthalmology 2021 21:193

    Content type: Research article

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  3. To minimize the risk of viral transmission, ophthalmology practices limited face-to-face encounters to only patients with urgent and emergent ophthalmic conditions in the weeks after the start of the COVID-19 ...

    Authors: Meghan K. Berkenstock, Paulina Liberman, Peter J. McDonnell and Benjamin C. Chaon

    Citation: BMC Ophthalmology 2021 21:139

    Content type: Research article

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  5. This study aims to compare the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and the senile cataract eyes. The association between inflammatory cytokine levels and cataract severity...

    Authors: Hui Wang and Yong Tao

    Citation: BMC Ophthalmology 2021 21:108

    Content type: Research article

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  6. Numerous studies have confirmed the association of ambient temperature and air pollution with a higher risk of morbidities, yet few have addressed their effect on the ocular system. The purpose of this study w...

    Authors: S. Khalaila, T. Coreanu, A. Vodonos, I. Kloog, A. Shtein, L. E. Colwell, V. Novack and E. Tsumi

    Citation: BMC Ophthalmology 2021 21:100

    Content type: Research article

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  7. This study aimed to establish a deep learning system for detecting the active and inactive phases of thyroid-associated ophthalmopathy (TAO) using magnetic resonance imaging (MRI). This system could provide fa...

    Authors: Chenyi Lin, Xuefei Song, Lunhao Li, Yinwei Li, Mengda Jiang, Rou Sun, Huifang Zhou and Xianqun Fan

    Citation: BMC Ophthalmology 2021 21:39

    Content type: Research article

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  8. To investigate the microbiologic spectrum of dacryocystitis in adult and pediatric groups, specifically the microbiologic differences between chronic dacryocystitis with nasolacrimal duct obstruction (NLDO) an...

    Authors: Ban Luo, Mu Li, Nan Xiang, Weikun Hu, Rong Liu and Xiaoqin Yan

    Citation: BMC Ophthalmology 2021 21:29

    Content type: Research article

    Published on:

  9. Orbital aspergillosis is a rare sight- and life-threatening fungal infection affecting immunocompromised or otherwise healthy patients. It is often misdiagnosed due to its unspecific clinical and radiologic ap...

    Authors: Mael Lever, Benjamin Wilde, Roman Pförtner, Cornelius Deuschl, Oliver Witzke, Stefanie Bertram, Anja Eckstein and Peter-Michael Rath

    Citation: BMC Ophthalmology 2021 21:22

    Content type: Case report

    Published on:

  12. Collagen cross-linking of the sclera is a promising approach to strengthen scleral rigidity and thus to inhibit eye growth in progressive myopia. Additionally, cross-linking might inhibit degrading processes i...

    Authors: Konstantin Krasselt, Cornelius Frommelt, Robert Brunner, Franziska Georgia Rauscher, Mike Francke and Nicole Körber

    Citation: BMC Ophthalmology 2020 20:488

    Content type: Research article

    Published on:

  13. We report a case of white circular spots of iridian atrophy, which we will call “polka dots” pattern, as a rare ophthalmological finding associated with uveitis secondary to varicella-zoster virus and Toxoplasma ...

    Authors: Juliana Muñoz-Ortiz, Olga Lorena Rubio-Romero, Maria Cecilia Cedeño, Karla Arteaga-Rivera and Alejandra de-la-Torre

    Citation: BMC Ophthalmology 2020 20:479

    Content type: Case report

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  14. Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of manag...

    Authors: Moustafa S. Magliyah, Abdulmajeed S. Al-Fakhri and Hassan A. Al-Dhibi

    Citation: BMC Ophthalmology 2020 20:470

    Content type: Case report

    Published on:

  18. Trachoma is a neglected eye disease and an important cause of preventable corneal blindness. In endemic areas, initial infection can occur in early childhood and following a recurrent episodes, it progresses t...

    Authors: Mesfin Wudu Kassaw, Ayele Mamo Abebe, Kirubel Dagnaw Tegegne, Mikiyas Amare Getu and Woldemichael Tadesse Bihonegn

    Citation: BMC Ophthalmology 2020 20:346

    Content type: Research article

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  19. Substance P (SP) is a nociceptive tachykinin which regulates the immune inflammatory reactions including monocyte chemoattractant protein 1 (MCP-1) production. Sequential second-eye cataract surgery patients o...

    Authors: Xianhui Gong, Yueping Ren, Xiuxiu Fang, Junyong Cai and E. Song

    Citation: BMC Ophthalmology 2020 20:339

    Content type: Research article

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  20. Orbital invasive aspergillosis infection is rare life-threatening infection, most commonly seen in immunocompromised patients and extremely rare in individuals without risk factors. Here we present a rare case...

    Authors: Jiahui Wu, Hao Zhou, Ruili Wei and Jinwei Cheng

    Citation: BMC Ophthalmology 2020 20:330

    Content type: Case report

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  21. Age-related Macular Degeneration (AMD) is a complex eye disease, which is genetically associated with different susceptibility loci. We planned to investigate the possible association of Complement Factor B (C...

    Authors: Nasrin Roshanipour, Maryam Ghaffari Laleh, Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Masoud Soheilian, Alireza Javadzadeh and Mehdi Yaseri

    Citation: BMC Ophthalmology 2020 20:323

    Content type: Research article

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  25. To describe the clinical characteristics and analyze the predictive factors associated with improved visual acuity of 359 patients with infectious endophthalmitis.

    Authors: Zhao Gao, Yunda Zhang, Xiaohong Gao, Ximei Zhang, Tao Ma, Gaiyun Li, Jingjing Wang and Hua Yan

    Citation: BMC Ophthalmology 2020 20:256

    Content type: Research article

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  27. This study aimed to assess and compare the clinical value of aqueous humor polymerase chain reaction (PCR) and serologic tests in patients diagnosed with suspected infectious uveitis.

    Authors: Wungrak Choi, Hyun Goo Kang, Eun Young Choi, Sung Soo Kim, Chan Yun Kim, Hyoung Jun Koh, Sung Chul Lee and Min Kim

    Citation: BMC Ophthalmology 2020 20:242

    Content type: Research article

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  29. The usefulness of povidone-iodine as an alternative to antimicrobial agents, for endophthalmitis, has recently been documented. We report a case of endogenous endophthalmitis successfully treated with intravit...

    Authors: Hiroki Tanaka, Hiroyuki Nakashizuka, Yoshinobu Mizuno and Takayuki Hattori

    Citation: BMC Ophthalmology 2020 20:217

    Content type: Case report

    Published on:

  30. There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamet...

    Authors: Wei Zhang, Han Han, Kang Feng, Xiaohong Wang, Mei Du, Xiangda Meng, Yuanyuan Liu, Bo Huang, Rodrigo Brant and Hua Yan

    Citation: BMC Ophthalmology 2020 20:208

    Content type: Research article

    Published on:

  32. The purpose of this study was to evaluate the role of systemic steroids in post-procedural endophthalmitis as the role of intravitreal steroids in treatment algorithms of endophthalmitis remain controversial.

    Authors: Christopher D. Conrady, Richard M. Feist Jr, Albert T. Vitale and Akbar Shakoor

    Citation: BMC Ophthalmology 2020 20:181

    Content type: Research article

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  34. Inflammation of RPE cells led to different kinds of eye diseases and affected the normal function of the retina. Furthermore, higher levels of ROCK1 and ROCK2 induced injury of endothelial cells and many infla...

    Authors: Zhao Gao, Qiang Li, Yunda Zhang, Xiaohong Gao, Haiyan Li and Zhigang Yuan

    Citation: BMC Ophthalmology 2020 20:134

    Content type: Research article

    Published on:

  35. Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE)...

    Authors: Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M. Nishiguchi, Hiroshi Kunikata and Toru Nakazawa

    Citation: BMC Ophthalmology 2020 20:126

    Content type: Research article

    Published on:

  36. Outcome measurements currently used in chronic uveitis care fail to cover the full patient perspective. The aim of this study is to develop a conceptual model of the factors that adult patients with chronic uv...

    Authors: Aline C. Stolk-Vos, Hamasa Kasigar, Karlijn J. Nijmeijer, Tom O. Missotten, Jan J. Busschbach, Joris J. van de Klundert and Leonieke W. Kranenburg

    Citation: BMC Ophthalmology 2020 20:125

    Content type: Research article

    Published on:

  37. Eye infection is a public health problem in developing countries including Ethiopia. Bacteria are major causative agents of eye infections that can lead to loss of vision. The objective of this study was to de...

    Authors: Ahmed Adem Mohammed, Musa Mohammed Ali and Mengistu Hailemariam Zenebe

    Citation: BMC Ophthalmology 2020 20:124

    Content type: Research article

    Published on:

  39. Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading...

    Authors: Kanae Fukutsu, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Satoru Kase, Kayo Suzuki, Hiroshi Shimizu, Yukiko Shibata, Fumihiko Yamawaki, Masahiro Onozawa and Susumu Ishida

    Citation: BMC Ophthalmology 2020 20:94

    Content type: Case report

    Published on:

  40. Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation d...

    Authors: Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Salai Madhumathi Parkunan, C. Blake Randall, Rachel L. Staats and Michelle C. Callegan

    Citation: BMC Ophthalmology 2018 18:96

    Content type: Research article

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  41. Clostridium perfringens is an uncommon pathogen in endophthalmitis, causing rapid destruction of ocular tissues. Clostridium perfringens infection typically occurs after penetrating injury with soil-contaminated ...

    Authors: Ghita Guedira, Nabil Taright, Hélène Blin, Thameur Fattoum, Jordan Leroy, Youssef El Samad, Solange Milazzo and Farida Hamdad

    Citation: BMC Ophthalmology 2018 18:88

    Content type: Case report

    Published on:

  42. Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease that affects the Retinal Pigment Epithelium and outer retina. The purpose of this study was to describe its...

    Authors: Olivia Xerri, Sawsen Salah, Dominique Monnet and Antoine P. Brézin

    Citation: BMC Ophthalmology 2018 18:76

    Content type: Research article

    Published on:

  43. Graves’ disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves’ Oph...

    Authors: Andrea Rau, Matthias Klopfer, Niklas Rommel, Mechthild Rau-Fornefeld and Andreas Kolk

    Citation: BMC Ophthalmology 2018 18:56

    Content type: Case report

    Published on:

  45. Cytomegalovirus (CMV) retinitis is an opportunistic infection that primarily affects immunocompromised individuals. Intravitreal ganciclovir injection monotherapy or in combination with systemic anti-CMV thera...

    Authors: Lawrence P. L. Iu, Michelle C. Y. Fan, Wai-Ching Lam and Ian Y. H. Wong

    Citation: BMC Ophthalmology 2018 18:36

    Content type: Case report

    Published on:

  46. Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained...

    Authors: Joo Yeon Kim, Ji Hwan Lee, Christopher Seungkyu Lee and Sung Chul Lee

    Citation: BMC Ophthalmology 2018 18:28

    Content type: Case report

    Published on:

  47. Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however...

    Authors: Chan Zhao, Fangtian Dong, Fei Gao, Xinshu Liu, Minghang Pei, Shanshan Jia and Meifen Zhang

    Citation: BMC Ophthalmology 2018 18:6

    Content type: Research article

    Published on:

  48. Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial ...

    Authors: Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi and Endre V. Nagy

    Citation: BMC Ophthalmology 2018 18:5

    Content type: Case report

    Published on:

  49. To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis.

    Authors: Sibylle Winterhalter, Uwe Diedrich Behrens, Daniel Salchow, Antonia M. Joussen and Uwe Pleyer

    Citation: BMC Ophthalmology 2017 17:252

    Content type: Research article

    Published on:

  50. To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model.

    Authors: Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J. Gonzalez-Lopez, Peter K. F. Addison, Mark Westcott and Carlos E. Pavesio

    Citation: BMC Ophthalmology 2017 17:245

    Content type: Research article

    Published on:

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