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Neuro-ophthalmology

This section considers submissions on clinical and basic science aspects of neuro-ophthalmology, including diagnosis, treatment and prevention of neurologic disorders affecting the oculomotor and visual systems as well as related molecular and cellular biology, genetics and pathophysiology.

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  1. We investigated structural injury patterns in the peripapillary retinal nerve fibre layer (p-RNFL) and ganglion cell inner plexiform layer (GCIPL) caused by ethambutol treatment.

    Authors: Wen-Yan Sheng, Ling-Ya Su, Wei Ge, Shuang-Qing Wu and Li-Wei Zhu

    Citation: BMC Ophthalmology 2021 21:132

    Content type: Research article

    Published on:

  2. Cogan’s anterior internuclear ophthalmoplegia (INO) is characterized by INO with inability to converge and commonly thought to be due to rostral midbrain lesion. A lesion outside midbrain that causes unilatera...

    Authors: Yong Zheng Wai, Qi Xiong Ng, Tsu Hong Lim and Lik Thai Lim

    Citation: BMC Ophthalmology 2021 21:105

    Content type: Case report

    Published on:

  3. Acquired color anomalies caused by cerebral trauma are classified as either achromatopsias or dyschromatopsias (Zeki, Brain 113:1721–1777, 1990). The three main brain regions stimulated by color are V1, the li...

    Authors: Yoko Mase, Yoshitsugu Matsui, Eriko Uchiyama, Hisashi Matsubara, Masahiko Sugimoto, Akiko Kubo and Mineo Kondo

    Citation: BMC Ophthalmology 2021 21:63

    Content type: Case report

    Published on:

  4. This study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postope...

    Authors: Peng Yang, Hao-Cheng Liu, E Qiu, Wei Wang, Jia-Liang Zhang, Li-Bin Jiang, Hong-Gang Liu and Jun Kang

    Citation: BMC Ophthalmology 2021 21:61

    Content type: Research article

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  5. To analyze the clinical characteristics, treatment and prognosis of children with unilateral retinoblastoma (RB) and intracranial segment of retrobulbar optic nerve invasion.

    Authors: Yi-Zhuo Wang, Yi Zhang, Dong-Sheng Huang, Ji-Tong Shi, Jian-Min Ma, Bin Li, Xiao-Lin Xu, Yan Zhou and Hua-Li Gu

    Citation: BMC Ophthalmology 2021 21:38

    Content type: Research article

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  8. At present, patients with ocular myasthenia gravis (OMG) are typically treated with systemic drugs. We investigated the use of dexamethasone injected in the peribulbar region or extraocular muscle to treat pat...

    Authors: Minghua Shi, Yingjia Ye, Junping Zhou, Aijiao Qin, Jing Cheng and Hongxing Ren

    Citation: BMC Ophthalmology 2020 20:432

    Content type: Research article

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  9. It is necessary to consider myopic optic disc tilt as it seriously impacts normal ocular parameters. However, ophthalmologic measurements are within inter-observer variability and time-consuming to get. This s...

    Authors: Baek Hwan Cho, Da Young Lee, Kyung-Ah Park, Sei Yeul Oh, Jong Hak Moon, Ga-In Lee, Hoon Noh, Joon Kyo Chung, Min Chae Kang and Myung Jin Chung

    Citation: BMC Ophthalmology 2020 20:407

    Content type: Research article

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  10. A majority of multiple sclerosis patients experience visual impairment, often as the initial presenting symptom of the disease. While structural changes in the retinal nerve fiber layer and optic nerve have de...

    Authors: Landon J. Rohowetz, Qui Vu, Lilit Ablabutyan, Sean M. Gratton, Nancy Kunjukunju, Billi S. Wallace and Peter Koulen

    Citation: BMC Ophthalmology 2020 20:367

    Content type: Research article

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  11. Neurosarcoidosis is a rare systemic disorder that can affect the eye and other organs, including the central nervous system. Neurosarcoidosis infiltrating the optic nerve presenting as central retinal vein occ...

    Authors: Chaoyi Feng, Qian Chen, Wei Liu, Yingwen Bi, Jiang Qian, Min Wang, Xinghuai Sun and Guohong Tian

    Citation: BMC Ophthalmology 2020 20:348

    Content type: Case report

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  14. MicroRNAs (miRNAs) are abnormally expressed in various ocular diseases, including age-related cataract. However, the role of miR-182-5p in the progression of age-related cataract remains unclear.

    Authors: Zhao-Na Li, Ming-Xu Ge and Zhong-Fang Yuan

    Citation: BMC Ophthalmology 2020 20:233

    Content type: Research article

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  15. Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease, characterized by acute or subacute, painless, bilateral visual loss. LHON is often misdiagnosed as optic neuritis at ...

    Authors: Chaeyeon Lee, Kyung-Ah Park, Ga-In Lee, Sei Yeul Oh, Ju-Hong Min and Byoung Joon Kim

    Citation: BMC Ophthalmology 2020 20:195

    Content type: Case report

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  16. Although most patients with visual impairment due to corneal diseases can be treated successfully with surgery, some require visual rehabilitation to restore reading ability. To evaluate the best LVAs especial...

    Authors: Michael Oeverhaus, Dirk Dekowski, Herbert Hirche, Joachim Esser, Barbara Schaperdoth-Gerlings and Anja Eckstein

    Citation: BMC Ophthalmology 2020 20:184

    Content type: Research article

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  18. Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-sm...

    Authors: Aisling B. Mc Glacken-Byrne, David Prentice, Danial Roshandel, Michael R. Brown, Philip Tuch, Kyle S.-Y. Yau, Padma Sivadorai, Mark R. Davis, Nigel G. Laing and Fred K. Chen

    Citation: BMC Ophthalmology 2020 20:68

    Content type: Case report

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  24. Children with a brain tumor have a high risk of impaired vision. Up to now, visual acuity measurement, visual field testing and orthoptic testing are the most informative diagnostic investigations for the asse...

    Authors: M. A. Nuijts, M. H. Degeling, I. Stegeman, A. Y. N. Schouten-van Meeteren and S. M. Imhof

    Citation: BMC Ophthalmology 2019 19:220

    Content type: Study protocol

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  25. Traumatic optic neuropathy (TON) is a form of optic nerve injury that occurs secondary to trauma and is etiologically associated with acute axonal loss with severe vision loss. Here, we reported longitudinal c...

    Authors: Won June Lee, Eun Hee Hong, Hae Min Park and Han Woong Lim

    Citation: BMC Ophthalmology 2019 19:216

    Content type: Case report

    Published on:

  26. To evaluate choroidal vascularity index (CVI) in eyes with internal carotid artery (ICA) stenosis using binarization tool in enhanced depth images scanned by spectral domain optical coherence tomography.

    Authors: Shuang Li, Xuqiang Lang, Wei Wang, Yang Yang, Jingjing Wang, Hongyang Li, Yanling Wang and Kang Wang

    Citation: BMC Ophthalmology 2019 19:215

    Content type: Research article

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  30. Morning glory syndrome is a relatively rare congenital optic disc anomaly that is often difficult to identify when associated with additional congenital ocular anomalies. This case report describes the diagnos...

    Authors: Heng Jiang, Youling Liang, Kejun Long and Jing Luo

    Citation: BMC Ophthalmology 2019 19:150

    Content type: Case report

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  31. To report the first case of a cerebral arteriovenous malformation (AVM) with ocular symptoms and review the characteristics of this case and the main point of confusion for the diagnosis of such a case.

    Authors: Shuhao Shen, Xiaoyong Liu, Jian Chen, Chengyou Yang, Changzheng Shi and Qing Zhou

    Citation: BMC Ophthalmology 2019 19:148

    Content type: Case report

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  36. It has been previously reported that one copy of the variable number tandem repeat (VNTR) B alleles of the GPIbα gene increases the risk of non-arteritic ischaemic optic neuropathy (NAION) and the second eye i...

    Authors: Christina S. Lim, Ajoy Sarkar and Christopher Knapp

    Citation: BMC Ophthalmology 2019 19:5

    Content type: Case report

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  37. This study aimes to characterize the fundus structural changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and the correlation between macular vessel density, retinal nerve fibre l...

    Authors: Hui Wang, Zhao-yang Meng, Song-guo Li, Jing-jing Wang, Jiao Sun and Hong-yang Li

    Citation: BMC Ophthalmology 2018 18:341

    Content type: Research article

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  38. This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia ...

    Authors: Anas Mohammad Albarrak, Yousef Mohammad, Sajjad Hussain, Sufia Husain and Taim Muayqil

    Citation: BMC Ophthalmology 2018 18:317

    Content type: Case report

    Published on:

  39. Although there are limited studies, recent data are lacking to accurately determine the magnitude of color blindness in Ethiopia and there is no evidence of such a study in Gish Abay town district. The purpose...

    Authors: Mengistu Zelalem Wale, Yekoye Abebe, Yilikal Adamu and Abebe Zelalem

    Citation: BMC Ophthalmology 2018 18:306

    Content type: Research article

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  40. A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further ...

    Authors: Jing-yu Min, Yanan Lv, Lei Mao, Yuan-yuan Gong, Qing Gu and Fang Wei

    Citation: BMC Ophthalmology 2018 18:304

    Content type: Research article

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  41. Granulomatosis with polyangiitis (GPA), a necrotizing granulomatous disease, very rarely involves the central nervous system (CNS), particularly the pituitary. Delayed treatment may cause permanent bilateral b...

    Authors: Xia Zhang, Bing Xing, Hui You, Huanwen Wu, Yong Zhong and Jin Ma

    Citation: BMC Ophthalmology 2018 18:299

    Content type: Case report

    Published on:

  42. Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient present...

    Authors: Guohong Tian, Weimin Chen, Qian Chen, Min Wang, Guixian Zhao, Zhenxin Li and Jiong Zhang

    Citation: BMC Ophthalmology 2018 18:282

    Content type: Case report

    Published on:

  43. Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especiall...

    Authors: Mário Luiz R. Monteiro, Kenzo Hokazono, Leonardo P. Cunha and Laurentino Biccas Neto

    Citation: BMC Ophthalmology 2018 18:278

    Content type: Case report

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  44. Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe reti...

    Authors: Xiujuan Zhao, Wei Qiu, Yuxin Zhang, Yan Luo, Xiulan Zhang, Lin Lu and Hui Yang

    Citation: BMC Ophthalmology 2018 18:247

    Content type: Research article

    Published on:

  45. Visual field loss occurs frequently in neurological conditions and perimetry is commonly requested for patients with suspected or known conditions. There are currently no guidelines for how visual fields in ne...

    Authors: Lauren R. Hepworth and Fiona J. Rowe

    Citation: BMC Ophthalmology 2018 18:241

    Content type: Research article

    Published on:

  47. Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognos...

    Authors: Huimin Hu, Weiling Zhang, Yizhuo Wang, Dongsheng Huang, Jitong Shi, Bin Li, Yi Zhang and Yan Zhou

    Citation: BMC Ophthalmology 2018 18:107

    Content type: Research article

    Published on:

  48. Cavernous carotid aneurysm (CCA) represents 2–9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bi...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen and Wimonwan Chokthaweesak

    Citation: BMC Ophthalmology 2018 18:25

    Content type: Case report

    Published on:

  50. Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Laye...

    Authors: Anuriti Aojula, Susan P Mollan, John Horsburgh, Andreas Yiangou, Kiera A Markey, James L Mitchell, William J Scotton, Pearse A Keane and Alexandra J Sinclair

    Citation: BMC Ophthalmology 2018 17:257

    Content type: Research article

    Published on:

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