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Neuro-ophthalmology

Section edited by Eric Singman

This section considers submissions on clinical and basic science aspects of neuro-ophthalmology, including diagnosis, treatment and prevention of neurologic disorders affecting the oculomotor and visual systems as well as related molecular and cellular biology, genetics and pathophysiology.

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  1. Content type: Case report

    Morning glory syndrome is a relatively rare congenital optic disc anomaly that is often difficult to identify when associated with additional congenital ocular anomalies. This case report describes the diagnos...

    Authors: Heng Jiang, Youling Liang, Kejun Long and Jing Luo

    Citation: BMC Ophthalmology 2019 19:150

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  2. Content type: Case report

    To report the first case of a cerebral arteriovenous malformation (AVM) with ocular symptoms and review the characteristics of this case and the main point of confusion for the diagnosis of such a case.

    Authors: Shuhao Shen, Xiaoyong Liu, Jian Chen, Chengyou Yang, Changzheng Shi and Qing Zhou

    Citation: BMC Ophthalmology 2019 19:148

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  7. Content type: Case report

    It has been previously reported that one copy of the variable number tandem repeat (VNTR) B alleles of the GPIbα gene increases the risk of non-arteritic ischaemic optic neuropathy (NAION) and the second eye i...

    Authors: Christina S. Lim, Ajoy Sarkar and Christopher Knapp

    Citation: BMC Ophthalmology 2019 19:5

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  8. Content type: Research article

    This study aimes to characterize the fundus structural changes in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and the correlation between macular vessel density, retinal nerve fibre l...

    Authors: Hui Wang, Zhao-yang Meng, Song-guo Li, Jing-jing Wang, Jiao Sun and Hong-yang Li

    Citation: BMC Ophthalmology 2018 18:341

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  9. Content type: Case report

    This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia ...

    Authors: Anas Mohammad Albarrak, Yousef Mohammad, Sajjad Hussain, Sufia Husain and Taim Muayqil

    Citation: BMC Ophthalmology 2018 18:317

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  10. Content type: Research article

    Although there are limited studies, recent data are lacking to accurately determine the magnitude of color blindness in Ethiopia and there is no evidence of such a study in Gish Abay town district. The purpose...

    Authors: Mengistu Zelalem Wale, Yekoye Abebe, Yilikal Adamu and Abebe Zelalem

    Citation: BMC Ophthalmology 2018 18:306

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  11. Content type: Research article

    A rodent model of photodynamic AION resulting from intravenous verteporfin is presented. The analysis of the morphological function, the pathological changes and the potential mechanism of action were further ...

    Authors: Jing-yu Min, Yanan Lv, Lei Mao, Yuan-yuan Gong, Qing Gu and Fang Wei

    Citation: BMC Ophthalmology 2018 18:304

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  12. Content type: Case report

    Granulomatosis with polyangiitis (GPA), a necrotizing granulomatous disease, very rarely involves the central nervous system (CNS), particularly the pituitary. Delayed treatment may cause permanent bilateral b...

    Authors: Xia Zhang, Bing Xing, Hui You, Huanwen Wu, Yong Zhong and Jin Ma

    Citation: BMC Ophthalmology 2018 18:299

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  13. Content type: Case report

    Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient present...

    Authors: Guohong Tian, Weimin Chen, Qian Chen, Min Wang, Guixian Zhao, Zhenxin Li and Jiong Zhang

    Citation: BMC Ophthalmology 2018 18:282

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  14. Content type: Case report

    Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especiall...

    Authors: Mário Luiz R. Monteiro, Kenzo Hokazono, Leonardo P. Cunha and Laurentino Biccas Neto

    Citation: BMC Ophthalmology 2018 18:278

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  15. Content type: Research article

    Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe reti...

    Authors: Xiujuan Zhao, Wei Qiu, Yuxin Zhang, Yan Luo, Xiulan Zhang, Lin Lu and Hui Yang

    Citation: BMC Ophthalmology 2018 18:247

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  16. Content type: Research article

    Visual field loss occurs frequently in neurological conditions and perimetry is commonly requested for patients with suspected or known conditions. There are currently no guidelines for how visual fields in ne...

    Authors: Lauren R. Hepworth and Fiona J. Rowe

    Citation: BMC Ophthalmology 2018 18:241

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  18. Content type: Research article

    Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognos...

    Authors: Huimin Hu, Weiling Zhang, Yizhuo Wang, Dongsheng Huang, Jitong Shi, Bin Li, Yi Zhang and Yan Zhou

    Citation: BMC Ophthalmology 2018 18:107

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  19. Content type: Case report

    Cavernous carotid aneurysm (CCA) represents 2–9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bi...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen and Wimonwan Chokthaweesak

    Citation: BMC Ophthalmology 2018 18:25

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  21. Content type: Research article

    Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Laye...

    Authors: Anuriti Aojula, Susan P Mollan, John Horsburgh, Andreas Yiangou, Kiera A Markey, James L Mitchell, William J Scotton, Pearse A Keane and Alexandra J Sinclair

    Citation: BMC Ophthalmology 2018 17:257

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  23. Content type: Research article

    Visual disturbances associated with isolated sphenoid sinus inflammatory diseases (ISSIDs) are easily misdiagnosed due to the nonspecific symptoms and undetectable anatomical location. The main objective of th...

    Authors: Lanlan Chen, Libin Jiang, Bentao Yang and Prem S. Subramanian

    Citation: BMC Ophthalmology 2017 17:237

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  24. Content type: Case report

    AZOOR was first described by Gass in 1993 as a syndrome with rapid loss of one or more extensive zones of the outer retinal segments. It is characterized by photopsia, minimal funduscopic changes, and electror...

    Authors: Yi Chun Kuo, Nancy Chen and Rong Kung Tsai

    Citation: BMC Ophthalmology 2017 17:236

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  25. Content type: Research article

    Many patients who suffer unilateral non-arteritic anterior ischemic optic neuropathy (NAION) will eventually develop the same condition in their other eye, worrying them about losing vision in both eyes. The p...

    Authors: Shay Keren, Mario Zanolli and Gad Dotan

    Citation: BMC Ophthalmology 2017 17:155

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  26. Content type: Case report

    Cytophagic histiocytic panniculitis (CHP) is a rare form of nodular panniculitis that may progress to panniculitis-like T-cell lymphoma. We report a case of CHP that first manifested as bilateral ptosis, which...

    Authors: Wang Liao, Songhua Xiao, Juanjuan Yong, Shengnuo Fan, Wenli Fang, Yuqiu Zheng and Jun Liu

    Citation: BMC Ophthalmology 2017 17:112

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  27. Content type: Case report

    Embozene® is a new neuroembolizing microsphere used to reduce intraoperative bleeding for head and neck tumours. We report a case of iatrogenic ophthalmic artery occlusion after Embozene® embolization of the e...

    Authors: Ng Wei Loon, Balwant Singh Gendeh, Rozman Zakaria, Jemaima Che Hamzah and Norshamsiah Md Din

    Citation: BMC Ophthalmology 2017 17:92

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  28. Content type: Research article

    Accurate evaluation of diplopia during bedside physical examination is challenging. We developed a new computerized red glass test (CRT) to detect, localize, and quantify diplopia and investigated whether the ...

    Authors: Han Soo Yoo, Eunjeong Park, Soolienah Rhiu, Hyuk-Jae Chang, Kyoungsub Kim, Joonsang Yoo, Ji Hoe Heo and Hyo Suk Nam

    Citation: BMC Ophthalmology 2017 17:71

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  29. Content type: Case report

    In the assessment of a pituitary mass, objective visual field testing represents a valuable means of evaluating mass effect, and thus in deciding whether surgical management is warranted.

    Authors: Nisha Nesaratnam, Peter B. M. Thomas, Ramez Kirollos, Algis J. Vingrys, George Y. X. Kong and Keith R. Martin

    Citation: BMC Ophthalmology 2017 17:53

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  30. Content type: Research article

    To investigate postural effects on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with non-arteritic ischemic optic neuropathy (NAION).

    Authors: Jee Myung Yang, Sang Woo Park, Yong Sok Ji, Jaeryung Kim, Chungkwon Yoo and Hwan Heo

    Citation: BMC Ophthalmology 2017 17:47

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  33. Content type: Case report

    We present a long term follow-up of a young female patient with choroidal infarction, primary open angle glaucoma and Flammer syndrome. The patient had no classical risk factors for vascular occlusions, except...

    Authors: Barbara Terelak-Borys, Iwona Grabska-Liberek, Anita Piekarniak-Wozniak and Katarzyna Konieczka

    Citation: BMC Ophthalmology 2017 17:23

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  35. Content type: Case report

    Closantel is a halogenated salicylanilide with a potent anti parasitic activity. It is widely used in management of parasitic infestation in animals, but is contraindicated in humans.

    Authors: Seyed Ali Tabatabaei, Mohammad Soleimani, Mohammad Reza Mansouri, Ahmad Mirshahi, Bahman Inanlou, Mojtaba Abrishami, Ahmad Reza Pakrah and Hamideh Masarat

    Citation: BMC Ophthalmology 2016 16:207

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  36. Content type: Research article

    The aim of this study was to determine the interocular differences in the peripapillary retinal nerve fibre layer (RNFL), peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) in hea...

    Authors: Mo Yang, Wei Wang, Quangang Xu, Shaoying Tan and Shihui Wei

    Citation: BMC Ophthalmology 2016 16:182

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  37. Content type: Research article

    Non-arteritic anterior ischemic optic neuropathy (NA-AION) is one of the most common types of ischemic optic neuropathy. Several recent studies suggested that abnormalities of choroidal thickness might be asso...

    Authors: Libin Jiang, Lanlan Chen, Xiujuan Qiu, Ran Jiang, Yaxing Wang, Liang Xu and Timothy Y. Y. Lai

    Citation: BMC Ophthalmology 2016 16:153

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  38. Content type: Research article

    There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among d...

    Authors: Eman S. Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M. Youssef, Heba M. Ibrahim and Ahmed H. Al-Sharqawi

    Citation: BMC Ophthalmology 2016 16:118

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  40. Content type: Research article

    The aim of this study was to assess the intraocular pressure and ocular biometric parameters in migraine patients during acute migraine attacks and compare them with painless period and healthy controls using ...

    Authors: Yaran Koban, Hatice Kose Ozlece, Gorkem Bilgin, Mustafa Koc, Halil Huseyin Cagatay, Emre I. Durgunlu and Ayse Burcu

    Citation: BMC Ophthalmology 2016 16:70

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  41. Content type: Research article

    The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using ...

    Authors: Blanca Ferrandez, Antonio Ferreras, Pilar Calvo, Beatriz Abadia, Jose M. Marin and Ana B. Pajarin

    Citation: BMC Ophthalmology 2016 16:40

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  43. Content type: Research article

    Rhino-orbito-cerebral mucormycosis(ROCM) is an invasive fungal infection that usually occurs in immunocompromised patients and sometimes presents as orbital apex syndrome(OAS) initially. It is rapidly fatal wi...

    Authors: Nan Jiang, Guiqiu Zhao, Shanshan Yang, Jing Lin, Liting Hu, Chengye Che, Qian Wang and Qiang Xu

    Citation: BMC Ophthalmology 2016 16:10

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  45. Content type: Research article

    The latency and amplitude of visual evoked cortical responses are known to be affected by refractive states, suggesting that they may be used as an objective index of refractive errors. In order to establish a...

    Authors: Masaya Suzuki, Mizuki Nagae, Yuko Nagata, Naoya Kumagai, Koji Inui and Ryusuke Kakigi

    Citation: BMC Ophthalmology 2015 15:162

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  47. Content type: Case report

    Tolosa-Hunt syndrome is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropathies. It is caused by an inflammatory process of unknown etiology.

    Authors: Tarek A Shazly, Ellen B Mitchell, Gabrielle R Bonhomme and Joel S Schuman

    Citation: BMC Ophthalmology 2015 15:51

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  48. Content type: Case report

    Leber’s hereditary optic neuropathy (LHON) refers to an optic nerve dysfunction due to mutations in the mitochondrial DNA, resulting in visual loss by apoptosis of retinal ganglion cells (RGC). In 20% of LHON ...

    Authors: Ayako Mizoguchi, Yuki Hashimoto, Yasuhiro Shinmei, Mayo Nozaki, Kan Ishijima, Yoshiaki Tagawa and Susumu Ishida

    Citation: BMC Ophthalmology 2015 15:27

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  49. Content type: Research article

    Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eve...

    Authors: Felix Grassmann, Richard Bergholz, Julia Mändl, Herbert Jägle, Klaus Ruether and Bernhard HF Weber

    Citation: BMC Ophthalmology 2015 15:18

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  50. Content type: Research article

    Vigabatrin (VGB) is an anti-epileptic medication which has been linked to peripheral constriction of the visual field. Documenting the natural history associated with continued VGB exposure is important when m...

    Authors: Miriam L Conway, Sarah L Hosking, Haogang Zhu and Robert P Cubbidge

    Citation: BMC Ophthalmology 2014 14:166

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