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Retina

Section edited by Hemant Khanna and Javier Zarranz-Ventura

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

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  1. Patients with center-involved diabetic macular edema (CI-DME) with good visual acuity (VA) represent a controversial clinical scenario in which a subthreshold laser might be a reasonable approach. We report a ...

    Authors: Alejandro Filloy, Victor Chong and Eduard Solé

    Citation: BMC Ophthalmology 2020 20:266

    Content type: Research article

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  2. Two cases with refractory macular edema secondary to adult-onset Coats’ disease underwent unsatisfactory treatment by intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs and retinal...

    Authors: Yewei Wang, Hua Fan, Ke Gao, Wei He and Yong Tao

    Citation: BMC Ophthalmology 2020 20:261

    Content type: Case report

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  3. Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF)...

    Authors: Hui Wang, Hui Lou, Yongrong Li, Fengtao Ji, Wei Chen, Qianyi Lu and Guoxu Xu

    Citation: BMC Ophthalmology 2020 20:260

    Content type: Research article

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  4. To investigate different tamponade effects of intravitreal silicone oil (SO) and sterilized air on macular vasculature and structure after successful retinal repair for macular-on rhegmatogenous retinal detach...

    Authors: Yifan Zhou, Siqi Zhang, Hao Zhou, Min Gao, Haiyun Liu and Xiaodong Sun

    Citation: BMC Ophthalmology 2020 20:249

    Content type: Research article

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  5. Dexamethasone intravitreal implants (0.7 mg) (Ozurdex®, Allergan Inc., Madison, NJ) are FDA approved for managing macular oedema (ME) of retinal vein occlusion (RVO). The major complications associated with in...

    Authors: Zhi-Yong Zhang, Xiu-Yun Liu and Tao Jiang

    Citation: BMC Ophthalmology 2020 20:247

    Content type: Case report

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  6. It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the treatment of macular edema (ME) secondary to branch retin...

    Authors: Shuang Song, Xiaobing Yu, Peng Zhang, Xiaoya Gu and Hong Dai

    Citation: BMC Ophthalmology 2020 20:241

    Content type: Research article

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  7. To evaluate the anatomical and functional responses in eyes with diabetic macular edema (DME) treated with ranibizumab under “1 + pro re nata (PRN)” regimen.

    Authors: Kunbei Lai, Chuangxin Huang, Longhui Li, Yajun Gong, Fabao Xu, Xiaojing Zhong, Lin Lu and Chenjin Jin

    Citation: BMC Ophthalmology 2020 20:229

    Content type: Research article

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  8. Internal limiting membrane (ILM) peeling increases the idiopathic macular hole (IMH) closure rate but causes the inner retina dimplings. This study is to introduce a method to minimally peel the ILM, and with ...

    Authors: Zizhong Hu, Huiming Qian, Silvia Fransisca, Xunyi Gu, Jiangdong Ji, Jianan Wang, Qinghuai Liu and Ping Xie

    Citation: BMC Ophthalmology 2020 20:228

    Content type: Technical advance

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  9. To compare the efficacy of one initial intravitreal injection of conbercept (IVC) versus three monthly IVCs in patients with macular edema (ME) after branch retinal vein occlusion (BRVO). Both options were fol...

    Authors: X. Chen, T. M. Hu, J. Zuo, H. Wu, Z. H. Liu, Y. X. Zhan, Y. Xia, J. Wang and W. Wei

    Citation: BMC Ophthalmology 2020 20:225

    Content type: Research article

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  10. Immune checkpoint inhibitors have recently been widely used for advanced cancers and are known to cause ocular complications. We herein report a case developing bilateral serous retinal detachments, without oc...

    Authors: Reina Miyamoto, Hiroyuki Nakashizuka, Koji Tanaka, Yu Wakatsuki, Hajime Onoe, Ryusaburo Mori and Akiyuki Kawamura

    Citation: BMC Ophthalmology 2020 20:221

    Content type: Case report

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  11. Minoxidil solution has routinely been used for decades for the treatment of androgenic alopecia. Central serous chorioretinopathy (CSCR) is a rare side-effect noted following prolonged topical minoxidil therap...

    Authors: Ramesh Venkatesh, Arpitha Pereira, Kushagra Jain and Naresh Kumar Yadav

    Citation: BMC Ophthalmology 2020 20:219

    Content type: Case report

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  12. To review treatment outcomes from real-world data of patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal aflibercept (IVT-AFL) injection.

    Authors: Michel Weber, Marcel Dominguez, Florence Coscas, Céline Faure, Stéphanie Baillif, Laurent Kodjikian and Salomon-Yves Cohen

    Citation: BMC Ophthalmology 2020 20:206

    Content type: Research article

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  13. Age-related macular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and globally, is a disease of the photoreceptor support system involving the retinal pigment epith...

    Authors: Christine A. Curcio, Gerald McGwin Jr, Srinivas R. Sadda, Zhihong Hu, Mark E. Clark, Kenneth R. Sloan, Thomas Swain, Jason N. Crosson and Cynthia Owsley

    Citation: BMC Ophthalmology 2020 20:196

    Content type: Study protocol

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  14. Intravitreal methotrexate has been proven to be an effective treatment method for vitreoretinal lymphoma. However, keratopathy occurs as the major side effect during treatment in most cases. The purpose of thi...

    Authors: Xian Zhou, Xianjin Zhou, Huimin Shi, Jie Lai, Qingping Wang, Yi Li, Kun Chen, Qingjian Li, Qiang Zhou, Xia Cao, Bobin Chen and Jianjiang Xiao

    Citation: BMC Ophthalmology 2020 20:189

    Content type: Research article

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  15. So far, only indirect evidence exists for the pharmacoresistant R-type voltage-gated Ca2+ channel (VGCC) to be involved in transretinal signaling by triggering GABA-release onto ON-bipolar neurons. This release o...

    Authors: Jan Niklas Lüke, Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider, Walid Albanna and Isha Akhtar-Schäfer

    Citation: BMC Ophthalmology 2020 20:182

    Content type: Research article

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  16. Polypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases. The presence of pachyvessels is one of the characteristics of pachychoroid disorders. However, the rel...

    Authors: Nobuo Ijuin, Hiroki Tsujinaka, Hiromasa Hirai, Hironobu Jimura, Shigeya Nakao, Mariko Yamashita, Tomo Nishi, Tetsuo Ueda and Nahoko Ogata

    Citation: BMC Ophthalmology 2020 20:170

    Content type: Research article

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  17. To evaluate postoperative changes in retinal capillary plexus and to assess contributing factors in postoperative visual improvement using optical coherence tomography angiography (OCT-A) in patients with idio...

    Authors: Jianbo Mao, Jimeng Lao, Chenyi Liu, Caiyun Zhang, Yiqi Chen, Jiwei Tao and Lijun Shen

    Citation: BMC Ophthalmology 2020 20:165

    Content type: Research article

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  18. Intraorbital metallic foreign bodies have varied clinical presentations. Here, we report the unusual case of intraoperative evidence of spontaneously healed posterior scleral perforation in a severe ballistic ...

    Authors: Fabiana Mallone, Michela Marcelli, Riccardo Monsellato, Federica Franzone, Magda Gharbiya and Alessandro Lambiase

    Citation: BMC Ophthalmology 2020 20:164

    Content type: Case report

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  19. SD-OCT is becoming commonplace in everyday practice. Vitreomacular adhesions (VMAs) are being more routinely diagnosed. Predictive studies to the natural course of VMA are thus clinically significant. Spectral...

    Authors: Ding-Ying Liao, Jorn-Hon Liu, Yu-Ping Zheng, Huei-Wen Shiu, Jian-Ming Wang and Hsiao-Ming Chao

    Citation: BMC Ophthalmology 2020 20:163

    Content type: Research article

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  20. To compare the choriocapillary flow density (CFD) among the fellow eyes of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and healthy controls using spectral-doma...

    Authors: Mingyue Luo, Xinyu Zhao, Nan Zhao, Mingzhen Yuan, Jingyuan Yang, Rongping Dai and Youxin Chen

    Citation: BMC Ophthalmology 2020 20:162

    Content type: Research article

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  21. To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients.

    Authors: Lulu Chen, Mingzhen Yuan, Lu Sun, Yuelin Wang and Youxin Chen

    Citation: BMC Ophthalmology 2020 20:154

    Content type: Research article

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  22. Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia and precursor to multiple myeloma. It has known ocular manifestations, but has not previously been shown to have an associat...

    Authors: Emily A. Eton, Gary Abrams, Naheed W. Khan and Abigail T. Fahim

    Citation: BMC Ophthalmology 2020 20:153

    Content type: Case report

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  23. Bilateral and multiple Valsalva-related sub-internal limiting membrane (ILM) hemorrhages in a familial retinal arteriolar tortuosity (FRAT) patient is rare, and we treated this patient by both observation and ...

    Authors: Ting Chen, Hongmei Zheng, Yunyun Wang, Junyi Hu and Changzheng Chen

    Citation: BMC Ophthalmology 2020 20:151

    Content type: Case report

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  24. The EVEREST II study reported superior polyp closure rates and visual outcomes using combination standard photodynamic therapy (PDT) with intravitreal ranibizumab in the treatment of polypoidal choroidal vascu...

    Authors: Wei Kiong Ngo, Wai Kitt Chee, Colin S. Tan and Tock Han Lim

    Citation: BMC Ophthalmology 2020 20:150

    Content type: Research article

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  25. Endogenous endophthalmitis is an infection of the eye secondary to sepsis, occurring in 0.04–0.5% of bacteremia or fungemia. Risk factors include intravenous drug abuse (IVDA), diabetes, indwelling catheters, ...

    Authors: Kathleen A. Regan, Nila S. Radhakrishnan, Jon D. Hammer, Benjamin D. Wilson, Lara Beth Gadkowski and Siva S. R. Iyer

    Citation: BMC Ophthalmology 2020 20:138

    Content type: Research article

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  26. Bullous serous retinal detachment (RD) with retinal pigment epithelial (RPE) tear is a rare and severe variant of chronic central serous chorioretinopathy (CSC). Due to its atypical presentation, it may raise ...

    Authors: Emilia Maggio, Maurizio Mete, Giorgia Maraone, Fabrizio Arena and Grazia Pertile

    Citation: BMC Ophthalmology 2020 20:133

    Content type: Case report

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  27. Evidence-based criteria for the treatment of autoimmune retinopathy (AIR) have not been established. The pathology and clinical features of each antibody causing AIR, and its long-term course are still undeter...

    Authors: Gen Miura, Takayuki Baba, Takehito Iwase, Hisao Ohde, Atsuhiro Kanda, Wataru Saito, Susumu Ishida and Shuichi Yamamoto

    Citation: BMC Ophthalmology 2020 20:132

    Content type: Case report

    Published on:

  28. To compare efficacy and safety of intravitreal aflibercept (IVA) injection with panretinal photocoagulation (PRP) versus early vitrectomy for diabetic vitreous hemorrhage (VH).

    Authors: Ahmed Hosni Abd Elhamid, Ahmed Abd El Alim Mohamed and Abeer Mohamed Khattab

    Citation: BMC Ophthalmology 2020 20:130

    Content type: Research article

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