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Section edited by Hemant Khanna and Javier Zarranz-Ventura

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

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  1. Content type: Research article

    Real-world data (RWD) has been a valuable addition to the scientific literature regarding treatment pathways, clinical outcomes and characteristics of patients with retinal diseases in recent years. Registries...

    Authors: Vincent Daien, Bora M. Eldem, James S. Talks, Jean-Francois Korobelnik, Paul Mitchell, Robert P. Finger, Taiji Sakamoto, Tien Yin Wong, Obaro Evuarherhe, Gemma Carter and Joao Carrasco

    Citation: BMC Ophthalmology 2019 19:206

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  2. Content type: Research article

    The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and...

    Authors: Jingyi Peng, Liuxueying Zhong, Li Ma, Jiayi Jin, Yongxin Zheng and Chenjin Jin

    Citation: BMC Ophthalmology 2019 19:204

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  3. Content type: Research article

    To document the visual acuity, spectral domain optical coherence tomography (SD-OCT) findings and prognosis in10 eyes of 6 patients with foveal damage from solar retinopathy in 1 year.

    Authors: Marwa Mahmoud Abdellah, Engy Mohammed Mostafa, Mohamed Abdelatif Anber, Islam Saad El Saman and Mohammed Ezz Eldawla

    Citation: BMC Ophthalmology 2019 19:201

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  4. Content type: Research article

    To compare the reoperation rate in patients with vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR) with or without preoperative intravitreal bevacizumab (IVB).

    Authors: Xuting Hu, Qintuo Pan, Jingwei Zheng, Zongming Song and Zongduan Zhang

    Citation: BMC Ophthalmology 2019 19:200

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  5. Content type: Case report

    To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment.

    Authors: Joong Hyun Park, Sang-Yoon Lee and Eun Kyoung Lee

    Citation: BMC Ophthalmology 2019 19:199

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  6. Content type: Research article

    To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab.

    Authors: Yuxiang Hu, Yi Cheng, Xiaoxuan Xu, Bo Yang, Feng Mei, Qiong Zhou, Li Yan, Jun Wang and Xiaorong Wu

    Citation: BMC Ophthalmology 2019 19:194

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  7. Content type: Correspondence

    In the recently published article entitled “Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma” Jacobsen et al. describe a case in which a hyper-intens...

    Authors: M. G. Jaarsma-Coes, T. A. Ferreira, G. P. M. Luyten and J. W. M. Beenakker

    Citation: BMC Ophthalmology 2019 19:193

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    The original article was published in BMC Ophthalmology 2018 18:320

  8. Content type: Research article

    Severe Retinopathy of Prematurity (ROP) is a serious vasoproliferative disorder that can affect extremely premature infants. It continues to be one of the most important preventable causes of blindness in chil...

    Authors: Mohammad T. Akkawi, Mohammad M. Shehadeh, Amjaad N. Abu Shams, Doaa M. Al-Hardan, Lara J. Omar, Omar H. Almahmoud and Jamal A. S. Qaddumi

    Citation: BMC Ophthalmology 2019 19:189

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  9. Content type: Research article

    With the diabetes mellitus (DM) prevalence increasing annually, the human grading of retinal images to evaluate DR has posed a substantial burden worldwide. SmartEye is a recently developed fundus image proces...

    Authors: Yi Xu, Yongyi Wang, Bin Liu, Lin Tang, Liangqing Lv, Xin Ke, Saiguang Ling, Lina Lu and Haidong Zou

    Citation: BMC Ophthalmology 2019 19:184

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  10. Content type: Research article

    To evaluate the efficacy of epiretinal membrane removal in patients with good best-corrected visual acuity (BCVA) for improving visual function and quality of life (QOL).

    Authors: Hiroyuki Nakashizuka, Yorihisa Kitagawa, Yu Wakatsuki, Koji Tanaka, Koichi Furuya, Takayuki Hattori, Ryusaburo Mori and Hiroyuki Shimada

    Citation: BMC Ophthalmology 2019 19:183

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  11. Content type: Research article

    To assess the relationship between different indications for trans pars plana vitrectomies (PPV’s) and the intraocular pressure (IOP), and the effect of multiple PPV’s on the IOP. We also examined whether ther...

    Authors: Hrvoje Kovacic, Roger C. W. Wolfs, Emine Kılıç and Wishal D. Ramdas

    Citation: BMC Ophthalmology 2019 19:175

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  12. Content type: Research article

    A patient’s health literacy is fundamental for navigating the health system and managing disease. This study aimed to compare the health literacy levels of patients with chronic retinal disease in Denmark.

    Authors: Sofie Jandorf, Marie Krogh Nielsen, Kristine Sørensen and Torben Lykke Sørensen

    Citation: BMC Ophthalmology 2019 19:174

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  13. Content type: Research article

    Age-related macular degeneration (AMD) is the primary cause of blindness and severe vision loss in developed countries and is responsible for 8.7% of blindness globally. Ultraviolet radiation can induce DNA br...

    Authors: Jiunn-Liang Chen, Chun-Tzu Hung, Joseph Jordan Keller, Hsien-Chung Lin and Yu-Jen Wu

    Citation: BMC Ophthalmology 2019 19:168

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  14. Content type: Research article

    Optical coherence tomography angiography (OCTA), an innovative image technique, renders visualization of ocular neovascularization through non-invasive means, which has been applied in recent years. Therefore,...

    Authors: Rui Wang, Zhenzhen Liang and Xin Liu

    Citation: BMC Ophthalmology 2019 19:162

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  15. Content type: Research article

    Central serous chorioretinopathy (CSCR) is a complex ocular entity that, in its chronic form, can lead to serious visual impairment and morphological damage to the retina.

    Authors: Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Małgorzata Kneba and Andrzej Grzybowski

    Citation: BMC Ophthalmology 2019 19:160

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  16. Content type: Case report

    We report a case of macular hole (MH) formation and retinal detachment after intravitreal conbercept injection for the treatment of choroidal neovascularization (CNV) secondary to degenerative myopia.

    Authors: Chuan-bin Sun, Yueye Wang, Shiyang Zhou, Xudong Fang, Danni Xu and Zhe Liu

    Citation: BMC Ophthalmology 2019 19:156

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  17. Content type: Case report

    A persistent hyaloid artery is a rare fetal remnant. Several complications such as amblyopia, vitreous hemorrhage, and retinal detachment have been reported. Here, we present a case of vitreous hemorrhage with...

    Authors: Hansol Jeon, Jinsoo Kim and Soonil Kwon

    Citation: BMC Ophthalmology 2019 19:141

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  18. Content type: Research article

    Inositol supplementation has been linked to beneficial effects on reducing the incidence of retinopathy of prematurity (ROP); however, it’s controversial. The meta-analysis aimed to check out the efficacy and ...

    Authors: Yang Du, Yue He, Yue-lin Wang, Jian-guo Zhou and Chao Chen

    Citation: BMC Ophthalmology 2019 19:135

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  19. Content type: Research article

    To evaluate the subfoveal choroidal thickness (SFCT) in eyes with macular edema (ME) secondary to retinal vein occlusion(RVO), and to investigate the short term response after a single intravitreal ranibizumab...

    Authors: Fen Tang, Fan Xu, Haibin Zhong, Xin Zhao, Mingliang Lv, Ke Yang, Chaolan Shen, Hui Huang, Jian Lv, Siming Zeng, Min Li and Qi Chen

    Citation: BMC Ophthalmology 2019 19:133

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  20. Content type: Research article

    Nerve growth factor (NGF), produced by Müller cells, and internal limiting membrane (ILM) have fundamental roles in the development of full-thickness macular hole (FTMH). However, the potential crosstalk betwe...

    Authors: Luyi Zhang, Xiaoxia Li, Xiaoqin Lin and Miaoqin Wu

    Citation: BMC Ophthalmology 2019 19:130

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  21. Content type: Research article

    To evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF) agents.

    Authors: Gaku Terauchi, Kei Shinoda, Hiroyuki Sakai, Makoto Kawashima, Celso Soiti Matsumoto, Atsushi Mizota and Yozo Miyake

    Citation: BMC Ophthalmology 2019 19:129

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  22. Content type: Research article

    To evaluate the efficacy of swept –source optical coherence tomography angiography (SS-OCTA) in grading macular perfusion in retinal vein occlusion.

    Authors: Magdy Moussa, Mahmoud Leila, Amr Saad Bessa, Mohamed Lolah, Mohsen Abou Shousha, Hazem Medhat El Hennawi and Tarek Abdelrazek Hafez

    Citation: BMC Ophthalmology 2019 19:127

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  23. Content type: Research article

    To delineate the characteristics of complicated familial exudative vitreoretinopathy (FEVR) patients diagnosed before surgery or intra−/post-operatively and to analyze the risk factors for the diagnostic timing.

    Authors: Fengjie Xia, Jiao Lyu, Ping Fei and Peiquan Zhao

    Citation: BMC Ophthalmology 2019 19:126

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  24. Content type: Research article

    To assess the changes in individual retinal layer thickness and visual function associated with gains in visual acuity after an intravitreal conbercept injection in the diabetic macular edema (DME) on spectral...

    Authors: Yupeng Xu, Yuan Qu, Yan Suo, Jian Gao, Xia Chen, Kun Liu and Xun Xu

    Citation: BMC Ophthalmology 2019 19:123

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  25. Content type: Research article

    To examine morphological and functional results after pars plana vitrectomy (PPV) with sulfur hexafluoride (SF6) gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachment (RRD) during 6 m...

    Authors: Dorota Borowicz, Katarzyna Nowomiejska, Dominika Nowakowska, Agnieszka Brzozowska, Mario D Toro, Teresio Avitabile, Anselm G. Jünemann and Robert Rejdak

    Citation: BMC Ophthalmology 2019 19:118

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  26. Content type: Research article

    We aimed to investigate the deformation of the outer nuclear layer using optical coherence tomography in patients with epiretinal membrane (ERM) and its relationship with metamorphopsia.

    Authors: Seiji Takagi, Shigeki Kudo, Hideo Yokota, Masahiro Akiba, Michiko Mandai, Yasuhiko Hirami, Masayo Takahashi, Yasuo Kurimoto and Masahiro Ishida

    Citation: BMC Ophthalmology 2019 19:113

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  27. Content type: Research article

    Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to ...

    Authors: Pan Long, Weiming Yan, Mengshan He, Qianli Zhang, Zhe Wang, Manhong Li, Junhui Xue, Tao Chen, Jing An and Zuoming Zhang

    Citation: BMC Ophthalmology 2019 19:112

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  28. Content type: Case report

    To report a case of unilateral peripheral cone dysfunction syndrome and evaluate the associated clinicopathological changes using swept-source optical coherence tomography (SS-OCT).

    Authors: Tetsuya Hasegawa, Soichi Tetsuka, Aya Yamaguchi, Chieko Kobashi, Tomomi Sato, Yoshiaki Tanaka and Akihiro Kakehashi

    Citation: BMC Ophthalmology 2019 19:111

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  29. Content type: Case report

    The involvement of choroidal lesions in acute macular neuroretinopathy (AMN) is not yet fully understood. We quantitatively examined sequential changes in the morphology and circulation hemodynamics of the cho...

    Authors: Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa and Susumu Ishida

    Citation: BMC Ophthalmology 2019 19:109

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  30. Content type: Research article

    To investigate, using optical coherence tomography angiography (OCT-A), changes in perfusion density and in the foveal avascular zone (FAZ) in eyes with idiopathic vitreomacular traction (VMT) after ocriplasmi...

    Authors: Lorenzo Iuliano, Giovanni Fogliato, Roberta Colombo, Riccardo Sacconi, Giuseppe Querques, Francesco Bandello and Marco Codenotti

    Citation: BMC Ophthalmology 2019 19:108

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  31. Content type: Case report

    To report the case of a 31-year-old patient with Hand, Foot and Mouth Disease (HFMD) and concurrent acute monocular maculopathy, and to describe multimodal imaging findings never before described including opt...

    Authors: Michael Reich, Bertan Cakir, Stevan Cvetkoski, Stefan J. Lang, Andreas Stahl, Thomas Ness, Hansjürgen Agostini and Clemens Lange

    Citation: BMC Ophthalmology 2019 19:104

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  32. Content type: Research article

    To describe the effects of intravitreal bevacizumab injection (IVB) and/or transpupillary thermotherapy (TTT) in the treatment of small pigmented choroidal lesions with subfoveal fluid (SFF), and to investigat...

    Authors: Junwon Lee, Hee Jung Kwon, Min Kim, Christopher Seungkyu Lee and Sung Chul Lee

    Citation: BMC Ophthalmology 2019 19:103

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  33. Content type: Case report

    Cancer-associated retinopathy (CAR) is associated with various malignancies, including small cell lung cancer (SCLC). It is difficult to recognize, but prompt diagnosis is crucial for the patient, as retinopat...

    Authors: William Carrera, Kathy A. Tsamis and Rajiv Shah

    Citation: BMC Ophthalmology 2019 19:101

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  34. Content type: Research article

    Retinopathy of prematurity (ROP), the primary cause of blindness in children, is a potential complication for 7.7% of live births in Mexico. Given that less than one-third of all neonatal intensive care units ...

    Authors: Roger Acevedo-Castellón, Paulina Ramírez-Neria and Renata García-Franco

    Citation: BMC Ophthalmology 2019 19:91

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  35. Content type: Research article

    The purpose of this study was to perform a systematic review of the current literature on simulator-based training in vitreoretinal surgery (VRS). We examined the results regarding simulated VRS and provided a...

    Authors: Rasmus Christian Rasmussen, Jakob Grauslund and Anna Stage Vergmann

    Citation: BMC Ophthalmology 2019 19:90

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  36. Content type: Research article

    The evidence on diagnostic test accuracy (DTA) of diabetic retinopathy (DR) screening utilising photographic studies by non-ophthalmologist personnel in low and middle-income country (LMIC) settings is scarce....

    Authors: Mapa Mudiyanselage Prabhath Nishantha Piyasena, Jennifer L. Y. Yip, David MacLeod, Min Kim and Venkata S. Murthy Gudlavalleti

    Citation: BMC Ophthalmology 2019 19:89

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  37. Content type: Research article

    To report the clinical course and outcomes of adjunctive dexamethasone implants in patients with atopic dermatitis (AD) and retinal detachment (RD) undergoing vitrectomy and silicone oil tamponade.

    Authors: Ah Ran Cho and Young Hee Yoon

    Citation: BMC Ophthalmology 2019 19:86

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  38. Content type: Research article

    To investigate the relationship between the foveal outer nuclear layer (ONL) thickness in the active and resolved phases of central serous chorioretinopathy (CSC), and its possible association with optical coh...

    Authors: Jia Yu, Yuan Lei, Qing Chang, Gezhi Xu, Xiaofeng Ye, Lei Li and Chunhui Jiang

    Citation: BMC Ophthalmology 2019 19:84

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