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Retina

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

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  1. The DRCR.net Protocol T clinical trial assessed the comparative efficacy and safety of anti-VEGF treatments including aflibercept, ranibizumab and bevacizumab in diabetic macular edema (DME). Post -hoc analyse...

    Authors: J. M. Ruiz-Moreno, F. de Andrés-Nogales and I. Oyagüez

    Citation: BMC Ophthalmology 2020 20:371

    Content type: Research article

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  2. Post-implantation visual outcomes in patients with the Argus II Retinal Prosthesis is dependent on a multitude of factors including the positioning of the electrode array on the retina. The purpose of this stu...

    Authors: Abhishek Naidu, Nimra Ghani, Mohammad Saad Yazdanie and Khurram Chaudhary

    Citation: BMC Ophthalmology 2020 20:366

    Content type: Research article

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  3. Valsalva retinopathy is known to occur as a sudden preretinal or sub-internal limiting membrane hemorrhage induced by a rapid rise in venous pressure following increased intrathoracic or intraabdominal pressur...

    Authors: Toshiya Miyaki, Teruyo Kida, Shou Oosuka, Masanori Fukumoto, Takaki Sato, Masayuki Nakajima and Tsunehiko Ikeda

    Citation: BMC Ophthalmology 2020 20:368

    Content type: Case report

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  4. Sialidosis is a rare genetic lysosomal storage disorder caused by a deficit of neuraminidase enzyme activity. Patients with sialidosis present various neurological disorders such as: myoclonic epilepsy and hyp...

    Authors: Settimio Rossi, Carlo Gesualdo, Antonio Tartaglione, Leonilda Bilo, Antonietta Coppola and Francesca Simonelli

    Citation: BMC Ophthalmology 2020 20:356

    Content type: Case report

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  5. Drainage of exudative retinal detachment may be necessary for either therapeutic or diagnostic purposes (or both). Here, we describe an external drainage technique for non-resolving vision-threatening exudativ...

    Authors: Matthew P. Simunovic, Emily H. Shao and Perach Osaadon

    Citation: BMC Ophthalmology 2020 20:349

    Content type: Case report

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  6. Given the two different kinds of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular holes with and without lamellar hole-associated epiretinal pro...

    Authors: Hanyue Xu, Ling Qin, Yifan Zhang, Yinan Xiao and Ming Zhang

    Citation: BMC Ophthalmology 2020 20:345

    Content type: Research article

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  7. Intraocular pressure (IOP) is an important physiological measure of the eye and is associated with some ocular disorders. We aimed to assess the influence of topical beta blocker-induced IOP reduction on lens-...

    Authors: Li Dong, Yi Fan Li, Hao Tian Wu, Hai Di Kou, Yin Jun Lan, Ya Xing Wang, Jost B. Jonas and Wen Bin Wei

    Citation: BMC Ophthalmology 2020 20:343

    Content type: Research article

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  8. The aim of this study was to evaluate the correlation between changes in the macular capillary network and macular edema (ME) recurrence with branch retinal vein occlusion (BRVO) using swept-source optical coh...

    Authors: Ji Hye Jang, Yu Cheol Kim and Jae Pil Shin

    Citation: BMC Ophthalmology 2020 20:341

    Content type: Research article

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  9. Silicone oil tamponade has become a mainstay in treatment of advanced retinal detachment due to multiple etiologies. The aim of this study is to assess the characteristics, fates and complications of long-term...

    Authors: Nakhleh E. Abu-Yaghi, Yazan A. Abu Gharbieh, Ahmad M. Al-Amer, Saif Aldeen S. AlRyalat, Mohammed B. Nawaiseh, Mohammad J. Darweesh, Leen R. Alkukhun, Alaa M. Abed, Omar A. Saleh and Osama H. Ababneh

    Citation: BMC Ophthalmology 2020 20:336

    Content type: Research article

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  10. Clinicians adopt varying strategies for antisepsis with PI, which to this day remains efficient, economical and effective. Clinicians should prudently consider effective PI application, and we thank Koerner an...

    Authors: Sivashanth Gnanasekaran, Sophie Rogers, Sanj Wickremasinghe and Sukhpal S. Sandhu

    Citation: BMC Ophthalmology 2020 20:328

    Content type: Correspondence

    Published on:

    The original article was published in BMC Ophthalmology 2020 20:29

  11. To determine the frequency of persistent disease activity following 3 loading doses of anti- vascular endothelial growth factor (VEGF) agents, and the anatomic and demographic predictors of early persistent di...

    Authors: Colin S. Tan, Louis W. Lim, Wei Kiong Ngo, Pandiyan Pannirselvam, Clarence See, Wai Kitt Chee and Nakul Saxena

    Citation: BMC Ophthalmology 2020 20:324

    Content type: Research article

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  12. To investigate swept-source optical coherence tomography angiography (SS-OCTA) for deep choroid visualization and choroidal vascular density (CVD) measurement.

    Authors: Erqian Wang, Xinyu Zhao, Jingyuan Yang and Youxin Chen

    Citation: BMC Ophthalmology 2020 20:321

    Content type: Research article

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  13. Leber congenital amaurosis (LCA) is the earliest onset and the most severe form of all inherited retinal degenerative disorders, characterized by blindness, or severe visual impairment from birth, and typicall...

    Authors: Shigeru Sato, Takeshi Morimoto, Sayaka Tanaka, Kikuko Hotta, Takashi Fujikado, Motokazu Tsujikawa and Kohji Nishida

    Citation: BMC Ophthalmology 2020 20:313

    Content type: Case report

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  14. Diabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and ocular diseases associated with the development of DME in a Japanese popu...

    Authors: Atsuki Kume and Kenji Kashiwagi

    Citation: BMC Ophthalmology 2020 20:309

    Content type: Research article

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  15. To evaluate if a combination therapy with micropulse diode laser (MPL) shows non-inferiority on visual acuity (BCVA) within 12 months in comparison to standard therapy, i.e. intravitreal injection of ranibizum...

    Authors: Olga Furashova, Patrick Strassburger, Klio Ai Becker and Katrin Engelmann

    Citation: BMC Ophthalmology 2020 20:308

    Content type: Research article

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  16. Free internal limiting membrane (ILM) flap tamponade technique is an alternative choice for treating large idiopathic macular holes (IMHs). However, the functional recovery related to this surgical approach is...

    Authors: Peirong Huang, Hong Wang, Fenge Chen, Jieqiong Chen, Yifan Hu, Junran Sun, Jingyang Feng and Hong Zhu

    Citation: BMC Ophthalmology 2020 20:302

    Content type: Research article

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  17. To investigate the expression and significance of mechanistic target of rapamycin complex 1(mTORC1) in diabetic retinopathy (DR), and to find new targets and new methods for the treatment of DR.

    Authors: Yanli Liu, Yarong Zheng, Yekai Zhou, Yi Liu, Mengxuan Xie, Wenjing Meng and Meixia An

    Citation: BMC Ophthalmology 2020 20:297

    Content type: Research article

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  18. Diabetic retinopathy (DR) is a microvascular complication of diabetes and a leading cause of blindness in working-age adults. The likelihood of visual impairment associated with DR is two-fold higher in the Af...

    Authors: Sarah L. Garvey, Maziyar M. Khansari, Xuejuan Jiang, Rohit Varma and Mahnaz Shahidi

    Citation: BMC Ophthalmology 2020 20:295

    Content type: Research article

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  19. Systematically review the evidence describing the impact of anti–vascular endothelial growth factor (anti-VEGF) therapy on neovascular age-related macular degeneration (nAMD) patient outcomes and healthcare re...

    Authors: Robert P. Finger, Vincent Daien, Bora M. Eldem, James S. Talks, Jean-Francois Korobelnik, Paul Mitchell, Taiji Sakamoto, Tien Yin Wong, Krystallia Pantiri and Joao Carrasco

    Citation: BMC Ophthalmology 2020 20:294

    Content type: Research article

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  20. We aimed to analyse multiple factors in the prediction of risk of postoperative recurrent vitreous haemorrhage (RVH) for non-clearing vitreous haemorrhage in patients with diabetic retinopathy (DR) who underwe...

    Authors: Yuhua Ding, Bangtao Yao, Hui Hang and Hui Ye

    Citation: BMC Ophthalmology 2020 20:292

    Content type: Research article

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  21. Age-related macular degeneration (AMD) is currently the leading cause of irreversible visual impairment in developed countries and seriously affects the health-related quality of life (HRQoL) of patients. Howe...

    Authors: Wei Bian, Junli Wan, Mingqiong Tan, Jun Su, Yi Yuan, Zonghua Wang and Shiying Li

    Citation: BMC Ophthalmology 2020 20:291

    Content type: Research article

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  22. Although many studies have reported clinical features, surgical outcomes of rhegmatogenous retinal detachment (RRD), studies focusing on total RRD are rare. In this study, we investigate the clinical characterist...

    Authors: Jae-Yun Sung, Min-Woo Lee, Yeo-Kyoung Won, Hyung-Bin Lim and Jung-Yeul Kim

    Citation: BMC Ophthalmology 2020 20:286

    Content type: Research article

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  23. To report a case of branch retinal artery occlusion (BRAO) secondary to high-altitude exposure and diabetic retinopathy (DR), and to characterize the retinal changes before and after hyperbaric oxygen (HBO) tr...

    Authors: Xue Feng, Luping Wang, Haiwei Wang, Hong Qi, Jianqiang Zhang and Yanling Wang

    Citation: BMC Ophthalmology 2020 20:281

    Content type: Case report

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  24. To investigate the ability of intraoperative optical coherence tomography (iOCT) during macular hole (MH) surgery to image different hole edge configurations and predict the restoration of retinal microstructu...

    Authors: Jiwei Tao, Huan Chen, Lin Zhu, Deming Pan, Jia Fang, Yiqi Chen, Jianbo Mao and Lijun Shen

    Citation: BMC Ophthalmology 2020 20:280

    Content type: Research article

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  25. Patients with center-involved diabetic macular edema (CI-DME) with good visual acuity (VA) represent a controversial clinical scenario in which a subthreshold laser might be a reasonable approach. We report a ...

    Authors: Alejandro Filloy, Victor Chong and Eduard Solé

    Citation: BMC Ophthalmology 2020 20:266

    Content type: Research article

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  26. Two cases with refractory macular edema secondary to adult-onset Coats’ disease underwent unsatisfactory treatment by intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs and retinal...

    Authors: Yewei Wang, Hua Fan, Ke Gao, Wei He and Yong Tao

    Citation: BMC Ophthalmology 2020 20:261

    Content type: Case report

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  27. Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF)...

    Authors: Hui Wang, Hui Lou, Yongrong Li, Fengtao Ji, Wei Chen, Qianyi Lu and Guoxu Xu

    Citation: BMC Ophthalmology 2020 20:260

    Content type: Research article

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  28. To investigate different tamponade effects of intravitreal silicone oil (SO) and sterilized air on macular vasculature and structure after successful retinal repair for macular-on rhegmatogenous retinal detach...

    Authors: Yifan Zhou, Siqi Zhang, Hao Zhou, Min Gao, Haiyun Liu and Xiaodong Sun

    Citation: BMC Ophthalmology 2020 20:249

    Content type: Research article

    Published on:

  29. Dexamethasone intravitreal implants (0.7 mg) (Ozurdex®, Allergan Inc., Madison, NJ) are FDA approved for managing macular oedema (ME) of retinal vein occlusion (RVO). The major complications associated with in...

    Authors: Zhi-Yong Zhang, Xiu-Yun Liu and Tao Jiang

    Citation: BMC Ophthalmology 2020 20:247

    Content type: Case report

    Published on:

  30. It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the treatment of macular edema (ME) secondary to branch retin...

    Authors: Shuang Song, Xiaobing Yu, Peng Zhang, Xiaoya Gu and Hong Dai

    Citation: BMC Ophthalmology 2020 20:241

    Content type: Research article

    Published on:

  31. Internal limiting membrane (ILM) peeling increases the idiopathic macular hole (IMH) closure rate but causes the inner retina dimplings. This study is to introduce a method to minimally peel the ILM, and with ...

    Authors: Zizhong Hu, Huiming Qian, Silvia Fransisca, Xunyi Gu, Jiangdong Ji, Jianan Wang, Qinghuai Liu and Ping Xie

    Citation: BMC Ophthalmology 2020 20:228

    Content type: Technical advance

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