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Retina

Section edited by Hemant Khanna and Javier Zarranz-Ventura

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

Page 1 of 9

  1. Postoperative intraretinal fluid (IRF) is reportedly associated with visual outcomes after epiretinal membrane (ERM) surgery. However, preoperative IRF is common, and persistent IRF would have different impact...

    Authors: Jae Jung Lee, Yeon Ji Jo, Han Jo Kwon, Seung Min Lee, Sung Who Park, Ik Soo Byon and Ji Eun Lee

    Citation: BMC Ophthalmology 2020 20:33

    Content type: Research article

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  2. Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic ...

    Authors: Jagger Koerner and Andrzej Grzybowski

    Citation: BMC Ophthalmology 2020 20:29

    Content type: Correspondence

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    The original article was published in BMC Ophthalmology 2019 19:62

  3. Following the principles of value-based health care, outcomes and processes of daily-practice eye care need to be systematically evaluated. We illustrate an approach that can be used to support data-driven qua...

    Authors: Margriet I. van der Reis, M. Elshout, Tos T. J. M. Berendschot, Yvonne de Jong-Hesse, Carroll A. B. Webers and Jan S. A. G. Schouten

    Citation: BMC Ophthalmology 2020 20:21

    Content type: Research article

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  4. To evaluate the efficacy and safety of two individualized ranibizumab retreatment schemes in neovascular age-related macular degeneration.

    Authors: Giovanni Staurenghi, Justus G. Garweg, Bianca S. Gerendas, Wayne Macfadden, Boris Gekkiev, Philippe Margaron, Cornelia Dunger-Baldauf and Petr Kolar

    Citation: BMC Ophthalmology 2020 20:18

    Content type: Research article

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  5. The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cy...

    Authors: Huiying Zhou, Xinyu Zhao, Mingzhen Yuan and Youxin Chen

    Citation: BMC Ophthalmology 2020 20:15

    Content type: Research article

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  6. The purpose of this study was to compare the anatomical and visual outcomes of inverted internal limiting membrane (ILM) flap technique and internal limiting membrane peeling in large macular holes (MH).

    Authors: Yu Shen, Xiaoqin Lin, Luyi Zhang and Miaoqin Wu

    Citation: BMC Ophthalmology 2020 20:14

    Content type: Research article

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  7. To compare the anatomical and functional outcomes of the inverted internal limiting membrane (ILM) flap technique and the complete ILM removal in the treatment of large stage 4 macular hole (MH) > 400 μm and t...

    Authors: Prithvi Ramtohul, Eric Parrat, Danièle Denis and Umberto Lorenzi

    Citation: BMC Ophthalmology 2020 20:11

    Content type: Research article

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  8. Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ...

    Authors: Huiying Zhao, Xiaona Wang, Yu Mao and Xiaoyan Peng

    Citation: BMC Ophthalmology 2020 20:10

    Content type: Research article

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  9. To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy.

    Authors: Wei Xu, Weijing Cheng, Xiaoyuan Cui and Guoxing Xu

    Citation: BMC Ophthalmology 2020 20:7

    Content type: Research article

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  10. Previous case reports have demonstrated the occurrence of ischemic optic neuropathy (ION) following intravitreal injections of antivascular endothelial growth factor (anti-VEGF). However, no previous studies h...

    Authors: Yu-Yen Chen, Pesus Chou, Yu-Fang Huang, Hung-Jen Chien, Yu-Chieh Wu, Chia-Chi Lee, Li-Ying Huang and Hsin-Hua Chen

    Citation: BMC Ophthalmology 2019 19:268

    Content type: Research article

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  11. The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function...

    Authors: Akihiro Shinkai, Wataru Saito, Yuki Hashimoto and Susumu Ishida

    Citation: BMC Ophthalmology 2019 19:267

    Content type: Case report

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  12. After pars plana vitrectomy with internal limiting membrane (ILM) peeling and gas tamponade, patients are often required to remain in a face-down position (FDP) to allow the gas bubble to push against the macu...

    Authors: Ting Ye, Ji-guo Yu, Lin Liao, Lan Liu, Ting Xia and Lei-lei Yang

    Citation: BMC Ophthalmology 2019 19:265

    Content type: Research article

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  13. To study the influencing factors for different healing patterns of patients with idiopathic macular holes (IMH) after vitrectomy surgery performed with the internal limiting membrane (ILM) flap technique.

    Authors: Yuyan Liu, Changlong Wu, Ying Wang, Yi Dong, Dongqing Liang, Bo Xiao, Quanhong Han and Yanhua Chu

    Citation: BMC Ophthalmology 2019 19:264

    Content type: Research article

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  14. Fluorescein angiography is an important and frequently used diagnostic tool in ophthalmological practice. In this case report we describe a patient who experienced an anaphylactic reaction after the injection ...

    Authors: Annemieke Clementine Bouman, Damaris de Kruijf, Judith Maria Antonia Emmen, Thijs Clemens David Rettig, Maria Jolande Charlotte Kooijman-de Groot and Miriam Christina Faes

    Citation: BMC Ophthalmology 2019 19:261

    Content type: Case report

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  15. Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1...

    Authors: Xiangyang Zhang, Xuemin Tian, Baike Zhang, Lisa Guo, Xiaodan Li and Yong Jia

    Citation: BMC Ophthalmology 2019 19:260

    Content type: Research article

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  16. Retinal pigment epithelium cells (RPEs) are critical for maintaining retinal homeostasis. Accumulation of age-related lipofuscin, N-retinylidene-N-retinylethanolamine (A2E), makes RPEs vulnerable to blue light...

    Authors: Jingyang Feng, Yuhong Chen, Bing Lu, Xiangjun Sun, Hong Zhu and Xiaodong Sun

    Citation: BMC Ophthalmology 2019 19:249

    Content type: Research article

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  17. The study was proposed to determine whether nerve growth factor (NGF) combined with an internal limiting membrane (ILM) insertion was effective in the large idiopathic full-thickness macular hole (iFTMH) therapy.

    Authors: Luyi Zhang, Xiaoxia Li, Xiaoli Yang, Yu Shen and Miaoqin Wu

    Citation: BMC Ophthalmology 2019 19:247

    Content type: Research article

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  18. Alström syndrome (AS) is a rare monogenic disorder characterized by progressive multi-organ pathology including retinal degeneration, hearing impairment and type 2 diabetes. Here we present clinical features i...

    Authors: Maria F. Shurygina, Maria A. Parker, Catie L. Schlechter, Rui Chen, Yumei Li, Richard G. Weleber, Paul Yang and Mark E. Pennesi

    Citation: BMC Ophthalmology 2019 19:246

    Content type: Case report

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  19. RP (retinitis pigmentosa) is a group of hereditary retinal degenerative diseases. XLRP is a relatively severe subtype of RP. Thus, it is necessary to identify genes and mutations in patients who present with X...

    Authors: Zhimeng Zhang, Hehua Dai, Lei Wang, Tianchang Tao, Jing Xu, Xiaowei Sun, Liping Yang and Genlin Li

    Citation: BMC Ophthalmology 2019 19:240

    Content type: Research article

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  20. So far only single cases with short follow-up have been reported on the use of intravitreal anti-VEGF for traumatic choroidal neovascularizations (CNV). This paper reports a large case series of patients with ...

    Authors: T. Barth, F. Zeman, H. Helbig and M.-A. Gamulescu

    Citation: BMC Ophthalmology 2019 19:239

    Content type: Research article

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  21. To evaluate 5-year outcomes of anti-vascular endothelial growth factor (VEGF) monotherapy and combination therapy of anti-VEGF agents and photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) ...

    Authors: Jingyuan Yang, Mingzhen Yuan, Erqian Wang, Song Xia and Youxin Chen

    Citation: BMC Ophthalmology 2019 19:237

    Content type: Research article

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  22. Conventional flash fundus cameras capture color images that are oversaturated in the red channel and washed out in the green and blue channels, resulting in a retinal picture that often looks flat and reddish....

    Authors: Valentina Sarao, Daniele Veritti, Enrico Borrelli, Srini Vas R. Sadda, Enea Poletti and Paolo Lanzetta

    Citation: BMC Ophthalmology 2019 19:231

    Content type: Research article

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  23. To evaluate the efficacy of micro-incision vitrectomy surgery (MIVS) using Lumera and Resight non-contact sutureless wide-angle viewing systems (WAVS) for primary rhegmatogenous retinal detachment (RRD), and t...

    Authors: Chun-Ting Lai, Wei-Hsun Kung, Chun-Ju Lin, Huan-Sheng Chen, Henry Bair, Jane-Ming Lin, Wen-Lu Chen, Peng-Tai Tien and Yi-Yu Tsai

    Citation: BMC Ophthalmology 2019 19:230

    Content type: Research article

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  24. Erythropoietin (EPO) is one of the systemic angiogenic factors, and its role in ocular angiogenesis and in diabetic retinopathy (DR) is not yet fully understood. The latest research data reveal a possible corr...

    Authors: Sofija Davidović, Nikola Babić, Sandra Jovanović, Sava Barišić, Desanka Grković and Aleksandar Miljković

    Citation: BMC Ophthalmology 2019 19:227

    Content type: Research article

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  25. Uveal effusion syndrome is a rare entity of idiopathic exudative detachments of uveal tissues and retina. Medical treatments with systemic steroids and antimetabolites have been tried but with variable results...

    Authors: Anadi Khatri, Sweta Singh, Kriti Joshi and Muna Kharel

    Citation: BMC Ophthalmology 2019 19:210

    Content type: Case report

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  26. Real-world data (RWD) has been a valuable addition to the scientific literature regarding treatment pathways, clinical outcomes and characteristics of patients with retinal diseases in recent years. Registries...

    Authors: Vincent Daien, Bora M. Eldem, James S. Talks, Jean-Francois Korobelnik, Paul Mitchell, Robert P. Finger, Taiji Sakamoto, Tien Yin Wong, Obaro Evuarherhe, Gemma Carter and Joao Carrasco

    Citation: BMC Ophthalmology 2019 19:206

    Content type: Research article

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  27. The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and...

    Authors: Jingyi Peng, Liuxueying Zhong, Li Ma, Jiayi Jin, Yongxin Zheng and Chenjin Jin

    Citation: BMC Ophthalmology 2019 19:204

    Content type: Research article

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  28. To document the visual acuity, spectral domain optical coherence tomography (SD-OCT) findings and prognosis in10 eyes of 6 patients with foveal damage from solar retinopathy in 1 year.

    Authors: Marwa Mahmoud Abdellah, Engy Mohammed Mostafa, Mohamed Abdelatif Anber, Islam Saad El Saman and Mohammed Ezz Eldawla

    Citation: BMC Ophthalmology 2019 19:201

    Content type: Research article

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  29. To compare the reoperation rate in patients with vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR) with or without preoperative intravitreal bevacizumab (IVB).

    Authors: Xuting Hu, Qintuo Pan, Jingwei Zheng, Zongming Song and Zongduan Zhang

    Citation: BMC Ophthalmology 2019 19:200

    Content type: Research article

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  30. To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment.

    Authors: Joong Hyun Park, Sang-Yoon Lee and Eun Kyoung Lee

    Citation: BMC Ophthalmology 2019 19:199

    Content type: Case report

    Published on:

  31. To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab.

    Authors: Yuxiang Hu, Yi Cheng, Xiaoxuan Xu, Bo Yang, Feng Mei, Qiong Zhou, Li Yan, Jun Wang and Xiaorong Wu

    Citation: BMC Ophthalmology 2019 19:194

    Content type: Research article

    Published on:

  32. In the recently published article entitled “Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma” Jacobsen et al. describe a case in which a hyper-intens...

    Authors: M. G. Jaarsma-Coes, T. A. Ferreira, G. P. M. Luyten and J. W. M. Beenakker

    Citation: BMC Ophthalmology 2019 19:193

    Content type: Correspondence

    Published on:

    The original article was published in BMC Ophthalmology 2018 18:320

  33. Severe Retinopathy of Prematurity (ROP) is a serious vasoproliferative disorder that can affect extremely premature infants. It continues to be one of the most important preventable causes of blindness in chil...

    Authors: Mohammad T. Akkawi, Mohammad M. Shehadeh, Amjaad N. Abu Shams, Doaa M. Al-Hardan, Lara J. Omar, Omar H. Almahmoud and Jamal A. S. Qaddumi

    Citation: BMC Ophthalmology 2019 19:189

    Content type: Research article

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  34. With the diabetes mellitus (DM) prevalence increasing annually, the human grading of retinal images to evaluate DR has posed a substantial burden worldwide. SmartEye is a recently developed fundus image proces...

    Authors: Yi Xu, Yongyi Wang, Bin Liu, Lin Tang, Liangqing Lv, Xin Ke, Saiguang Ling, Lina Lu and Haidong Zou

    Citation: BMC Ophthalmology 2019 19:184

    Content type: Research article

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  35. To evaluate the efficacy of epiretinal membrane removal in patients with good best-corrected visual acuity (BCVA) for improving visual function and quality of life (QOL).

    Authors: Hiroyuki Nakashizuka, Yorihisa Kitagawa, Yu Wakatsuki, Koji Tanaka, Koichi Furuya, Takayuki Hattori, Ryusaburo Mori and Hiroyuki Shimada

    Citation: BMC Ophthalmology 2019 19:183

    Content type: Research article

    Published on:

  36. To assess the relationship between different indications for trans pars plana vitrectomies (PPV’s) and the intraocular pressure (IOP), and the effect of multiple PPV’s on the IOP. We also examined whether ther...

    Authors: Hrvoje Kovacic, Roger C. W. Wolfs, Emine Kılıç and Wishal D. Ramdas

    Citation: BMC Ophthalmology 2019 19:175

    Content type: Research article

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  37. A patient’s health literacy is fundamental for navigating the health system and managing disease. This study aimed to compare the health literacy levels of patients with chronic retinal disease in Denmark.

    Authors: Sofie Jandorf, Marie Krogh Nielsen, Kristine Sørensen and Torben Lykke Sørensen

    Citation: BMC Ophthalmology 2019 19:174

    Content type: Research article

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  38. Age-related macular degeneration (AMD) is the primary cause of blindness and severe vision loss in developed countries and is responsible for 8.7% of blindness globally. Ultraviolet radiation can induce DNA br...

    Authors: Jiunn-Liang Chen, Chun-Tzu Hung, Joseph Jordan Keller, Hsien-Chung Lin and Yu-Jen Wu

    Citation: BMC Ophthalmology 2019 19:168

    Content type: Research article

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  39. Optical coherence tomography angiography (OCTA), an innovative image technique, renders visualization of ocular neovascularization through non-invasive means, which has been applied in recent years. Therefore,...

    Authors: Rui Wang, Zhenzhen Liang and Xin Liu

    Citation: BMC Ophthalmology 2019 19:162

    Content type: Research article

    Published on:

  40. Central serous chorioretinopathy (CSCR) is a complex ocular entity that, in its chronic form, can lead to serious visual impairment and morphological damage to the retina.

    Authors: Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Małgorzata Kneba and Andrzej Grzybowski

    Citation: BMC Ophthalmology 2019 19:160

    Content type: Research article

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  41. We report a case of macular hole (MH) formation and retinal detachment after intravitreal conbercept injection for the treatment of choroidal neovascularization (CNV) secondary to degenerative myopia.

    Authors: Chuan-bin Sun, Yueye Wang, Shiyang Zhou, Xudong Fang, Danni Xu and Zhe Liu

    Citation: BMC Ophthalmology 2019 19:156

    Content type: Case report

    Published on:

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